Search Results - "Gertz, Michael"

Predicting cancer prognosis and drug response from the tumor microbiome by Hermida, Leandro C., Gertz, E. Michael, Ruppin, Eytan

“…Tumor gene expression is predictive of patient prognosis in some cancers. However, RNA-seq and whole genome sequencing data contain not only reads from host…”
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The phenotype of human STK4 deficiency by Abdollahpour, Hengameh, Appaswamy, Giridharan, Kotlarz, Daniel, Diestelhorst, Jana, Beier, Rita, Schäffer, Alejandro A., Gertz, E. Michael, Schambach, Axel, Kreipe, Hans H., Pfeifer, Dietmar, Engelhardt, Karin R., Rezaei, Nima, Grimbacher, Bodo, Lohrmann, Sabine, Sherkat, Roya, Klein, Christoph

“…We describe a novel clinical phenotype associating T- and B-cell lymphopenia, intermittent neutropenia, and atrial septal defects in 3 members of a…”
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Medication effects on the gut microbiome in allo-HCT by Robinson, Welles, Gertz, E. Michael, Greten, Tim F., Ruppin, Eytan

“…Decreased gut microbiome diversity has been associated with negative outcome in allogeneic hematopoietic stem cell transfer (HCT). A study published in this…”
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Prediction of Human Intestinal First-Pass Metabolism of 25 CYP3A Substrates from In Vitro Clearance and Permeability Data by GERTZ, Michael, HARRISON, Anthony, HOUSTON, J. Brian, GALETIN, Aleksandra

“…Intestinal first-pass metabolism may contribute to low oral drug bioavailability and drug-drug interactions, particularly for CYP3A substrates. The current…”
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Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor by Glocker, Erik-Oliver, Kotlarz, Daniel, Boztug, Kaan, Gertz, E. Michael, Schäffer, Alejandro A, Noyan, Fatih, Perro, Mario, Diestelhorst, Jana, Allroth, Anna, Murugan, Dhaarini, Hätscher, Nadine, Pfeifer, Dietmar, Sykora, Karl-Walter, Sauer, Martin, Kreipe, Hans, Lacher, Martin, Nustede, Rainer, Woellner, Cristina, Baumann, Ulrich, Salzer, Ulrich, Koletzko, Sibylle, Shah, Neil, Segal, Anthony W, Sauerbrey, Axel, Buderus, Stephan, Snapper, Scott B, Grimbacher, Bodo, Klein, Christoph

“…Genetic analyses showed that mutations affecting the interleukin-10 receptor are associated with early-onset colitis. Further molecular analyses showed that…”
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Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity by Lopez-Herrera, Gabriela, Tampella, Giacomo, Pan-Hammarström, Qiang, Herholz, Peer, Trujillo-Vargas, Claudia M., Phadwal, Kanchan, Simon, Anna Katharina, Moutschen, Michel, Etzioni, Amos, Mory, Adi, Srugo, Izhak, Melamed, Doron, Hultenby, Kjell, Liu, Chonghai, Baronio, Manuela, Vitali, Massimiliano, Philippet, Pierre, Dideberg, Vinciane, Aghamohammadi, Asghar, Rezaei, Nima, Enright, Victoria, Du, Likun, Salzer, Ulrich, Eibel, Hermann, Pfeifer, Dietmar, Veelken, Hendrik, Stauss, Hans, Lougaris, Vassilios, Plebani, Alessandro, Gertz, E. Michael, Schäffer, Alejandro A., Hammarström, Lennart, Grimbacher, Bodo

“…Most autosomal genetic causes of childhood-onset hypogammaglobulinemia are currently not well understood. Most affected individuals are simplex cases, but both…”
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Composition-based statistics and translated nucleotide searches: improving the TBLASTN module of BLAST by Gertz, E Michael, Yu, Yi-Kuo, Agarwala, Richa, Schäffer, Alejandro A, Altschul, Stephen F

“…TBLASTN is a mode of operation for BLAST that aligns protein sequences to a nucleotide database translated in all six frames. We present the first description…”
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Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome by Kotlarz, Daniel, Ziętara, Natalia, Uzel, Gulbu, Weidemann, Thomas, Braun, Christian J, Diestelhorst, Jana, Krawitz, Peter M, Robinson, Peter N, Hecht, Jochen, Puchałka, Jacek, Gertz, E Michael, Schäffer, Alejandro A, Lawrence, Monica G, Kardava, Lela, Pfeifer, Dietmar, Baumann, Ulrich, Pfister, Eva-Doreen, Hanson, Eric P, Schambach, Axel, Jacobs, Roland, Kreipe, Hans, Moir, Susan, Milner, Joshua D, Schwille, Petra, Mundlos, Stefan, Klein, Christoph

“…Primary immunodeficiencies (PIDs) represent exquisite models for studying mechanisms of human host defense. In this study, we report on two unrelated kindreds,…”
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Contribution of Intestinal Cytochrome P450-Mediated Metabolism to Drug-Drug Inhibition and Induction Interactions by Galetin, Aleksandra, Gertz, Michael, Brian Houston, J.

“…Current drug-drug interaction (DDI) prediction models incorporate intestinal interaction as the ratio of the intestinal availability in the presence and…”
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The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency by Engelhardt, Karin R., PhD, Gertz, Michael E., PhD, Keles, Sevgi, MD, Schäffer, Alejandro A., PhD, Sigmund, Elena C., BSc, Glocker, Cristina, PhD, Saghafi, Shiva, MSc, Pourpak, Zahra, MD, PhD, Ceja, Ruben, MSc, Sassi, Atfa, PhD, Graham, Laura E., BSc, MBChB, Massaad, Michel J., PhD, Mellouli, Fethi, MD, Ben-Mustapha, Imen, MD, Khemiri, Monia, MD, Kilic, Sara Sebnem, MD, Etzioni, Amos, MD, Freeman, Alexandra F., MD, Thiel, Jens, MD, Schulze, Ilka, MD, Al-Herz, Waleed, MD, Metin, Ayse, MD, PhD, Sanal, Özden, MD, Tezcan, Ilhan, MD, Yeganeh, Mehdi, MD, Niehues, Tim, MD, Dueckers, Gregor, MD, Weinspach, Sebastian, MD, Patiroglu, Turkan, MD, Unal, Ekrem, MD, Dasouki, Majed, MD, Yilmaz, Mustafa, MD, Genel, Ferah, MD, Aytekin, Caner, MD, Kutukculer, Necil, MD, Somer, Ayper, MD, Kilic, Mehmet, MD, Reisli, Ismail, MD, Camcioglu, Yildiz, MD, Gennery, Andrew R., MD, Cant, Andrew J., MD, Jones, Alison, MD, Gaspar, Bobby H., MD, Arkwright, Peter D., MD, DPhil, Pietrogrande, Maria C., MD, Baz, Zeina, MD, Al-Tamemi, Salem, MD, Lougaris, Vassilios, MD, Lefranc, Gerard, PhD, Megarbane, Andre, MD, PhD, Boutros, Jeannette, MD, Galal, Nermeen, MD, Bejaoui, Mohamed, MD, Barbouche, Mohamed-Ridha, MD, PhD, Geha, Raif S., MD, Chatila, Talal A., MD, MSc, Grimbacher, Bodo, MD

“…Background Mutations in dedicator of cytokinesis 8 (DOCK8) cause a combined immunodeficiency (CID) also classified as autosomal recessive (AR) hyper-IgE…”
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Protein database searches using compositionally adjusted substitution matrices by Altschul, Stephen F., Wootton, John C., Gertz, E. Michael, Agarwala, Richa, Morgulis, Aleksandr, Schäffer, Alejandro A., Yu, Yi‐Kuo

“…Almost all protein database search methods use amino acid substitution matrices for scoring, optimizing, and assessing the statistical significance of sequence…”
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Cyclosporine Inhibition of Hepatic and Intestinal CYP3A4, Uptake and Efflux Transporters: Application of PBPK Modeling in the Assessment of Drug-Drug Interaction Potential by Gertz, Michael, Cartwright, Catherine M., Hobbs, Michael J., Kenworthy, Kathryn E., Rowland, Malcolm, Houston, J. Brian, Galetin, Aleksandra

“…Purpose To apply physiologically-based pharmacokinetic (PBPK) modeling to investigate the consequences of reduction in activity of hepatic and intestinal…”
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Tumor heterogeneity assessed by sequencing and fluorescence in situ hybridization (FISH) data by Lei, Haoyun, Gertz, E Michael, Schäffer, Alejandro A, Fu, Xuecong, Tao, Yifeng, Heselmeyer-Haddad, Kerstin, Torres, Irianna, Li, Guibo, Xu, Liqin, Hou, Yong, Wu, Kui, Shi, Xulian, Dean, Michael, Ried, Thomas, Schwartz, Russell

“…Abstract Motivation Computational reconstruction of clonal evolution in cancers has become a crucial tool for understanding how tumors initiate and progress…”
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Single-cell resolved ploidy and chromosomal aberrations in nonalcoholic steatohepatitis-(NASH) induced hepatocellular carcinoma and its precursor lesions by Friemel, Juliane, Torres, Irianna, Brauneis, Elizabeth, Thörner, Tim, Schäffer, Alejandro A., Gertz, E. Michael, Grob, Tobias, Seidl, Kati, Weber, Achim, Ried, Thomas, Heselmeyer-Haddad, Kerstin

“…Nonalcoholic steatohepatitis (NASH)-induced hepatocellular carcinoma (HCC) and its precursor, nonalcoholic fatty liver disease (NAFLD) are an unmet health…”
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A fast and symmetric DUST implementation to mask low-complexity DNA sequences by Morgulis, Aleksandr, Gertz, E Michael, Schäffer, Alejandro A, Agarwala, Richa

“…The DUST module has been used within BLAST for many years to mask low-complexity sequences. In this paper, we present a new implementation of the DUST module…”
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Single-Cell-Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response by Braun, Rüdiger, Anthuber, Lena, Hirsch, Daniela, Wangsa, Darawalee, Lack, Justin, McNeil, Nicole E, Heselmeyer-Haddad, Kerstin, Torres, Irianna, Wangsa, Danny, Brown, Markus A, Tubbs, Anthony, Auslander, Noam, Gertz, E Michael, Brauer, Philip R, Cam, Margaret C, Sackett, Dan L, Habermann, Jens K, Nussenzweig, Andre, Ruppin, Eytan, Zhang, Zhongqiu, Rosenberg, Daniel W, Ried, Thomas

“…The standard treatment of patients with locally advanced rectal cancer consists of preoperative chemoradiotherapy (CRT) followed by surgery. However, the…”
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Reduced Physiologically-Based Pharmacokinetic Model of Repaglinide: Impact of OATP1B1 and CYP2C8 Genotype and Source of In Vitro Data on the Prediction of Drug-Drug Interaction Risk by Gertz, Michael, Tsamandouras, Nikolaos, Säll, Carolina, Houston, J. Brian, Galetin, Aleksandra

“…ABSTRACT Purpose To investigate the effect of OATP1B1 genotype as a covariate on repaglinide pharmacokinetics and drug-drug interaction (DDIs) risk using a…”
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Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data by KILFORD, Peter J, GERTZ, Michael, HOUSTON, J. Brian, GALETIN, Aleksandra

“…Analogous to the fraction unbound in microsomes (fu mic ), fraction unbound in hepatocyte incubations (fu hep ) is an important parameter in the prediction of…”
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Integration of adeno-associated virus (AAV) into the genomes of most Thai and Mongolian liver cancer patients does not induce oncogenesis by Schäffer, Alejandro A, Dominguez, Dana A, Chapman, Lesley M, Gertz, E Michael, Budhu, Anuradha, Forgues, Marshonna, Chaisaingmongkol, Jittiporn, Rabibhadana, Siritida, Pupacdi, Benjarath, Wu, Xiaolin, Bayarsaikhan, Enkhjargal, Harris, Curtis C, Ruchirawat, Mathuros, Ruppin, Eytan, Wang, Xin Wei

“…Engineered versions of adeno-associated virus (AAV) are commonly used in gene therapy but evidence revealing a potential oncogenic role of natural AAV in…”
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In silico modeling and simulation of organ‐on‐a‐chip systems to support data analysis and a priori experimental design by Milani, Nicoló, Parrott, Neil, Galetin, Aleksandra, Fowler, Stephen, Gertz, Michael

“…Organ‐on‐a‐chip (OoC) systems are a promising new class of in vitro devices that can combine various tissues, cultured in different compartments, linked by…”
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