Search Results - "Gertz, Hermann‐Josef"

Cerebral amyloid-β PET with florbetaben (18 F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study by Barthel, Henryk, Dr, Gertz, Hermann-Josef, MD, Dresel, Stefan, MD, Peters, Oliver, MD, Bartenstein, Peter, MD, Buerger, Katharina, MD, Hiemeyer, Florian, PhD, Wittemer-Rump, Sabine M, PhD, Seibyl, John, MD, Reininger, Cornelia, MD, Sabri, Osama, MD

“…Summary Background Imaging with amyloid-β PET can potentially aid the early and accurate diagnosis of Alzheimer's disease. Florbetaben (18 F) is a promising18…”
Get full text

Early neurone loss in Alzheimer's disease: cortical or subcortical? by Arendt, Thomas, Brückner, Martina K, Morawski, Markus, Jäger, Carsten, Gertz, Hermann-Josef

“…Alzheimer's disease (AD) is a degenerative disorder where the distribution of pathology throughout the brain is not random but follows a predictive pattern…”
Get full text

Individualized support for informal caregivers of people with dementia - effectiveness of the German adaptation of REACH II by Berwig, Martin, Heinrich, Stephanie, Spahlholz, Jenny, Hallensleben, Nina, Brähler, Elmar, Gertz, Hermann-Josef

“…Individualized, outreach and structured multicomponent interventions are a promising intervention approach to relieve the burden of informal caregivers of…”
Get full text

Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease by Schmidt, Frank M, Kratzsch, Juergen, Gertz, Hermann-Josef, Tittmann, Mandy, Jahn, Ina, Pietsch, Uta-Carolin, Kaisers, Udo X, Thiery, Joachim, Hegerl, Ulrich, Schönknecht, Peter

“…Ancillary to decline in cognitive abilities, patients with Alzheimer's disease (AD) frequently suffer from behavioural and psychological symptoms of dementia…”
Get full text

(+)-[18F]Flubatine as a novel α4β2 nicotinic acetylcholine receptor PET ligand—results of the first-in-human brain imaging application in patients with β-amyloid PET-confirmed Alzheimer’s disease and healthy controls by Tiepolt, Solveig, Becker, Georg-Alexander, Wilke, Stephan, Cecchin, Diego, Rullmann, Michael, Meyer, Philipp M., Barthel, Henryk, Hesse, Swen, Patt, Marianne, Luthardt, Julia, Wagenknecht, Gudrun, Sattler, Bernhard, Deuther-Conrad, Winnie, Ludwig, Friedrich-Alexander, Fischer, Steffen, Gertz, Hermann-Josef, Smits, René, Hoepping, Alexander, Steinbach, Jörg, Brust, Peter, Sabri, Osama

“…Purposes We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)–targeting radioligand (+)-[ 18…”
Get full text

Acetylcholine receptors in dementia and mild cognitive impairment by Sabri, Osama, Kendziorra, Kai, Wolf, Henrike, Gertz, Hermann-Josef, Brust, Peter

“…Purpose To clarify whether changes in the cholinergic transmission occur early in the course of Alzheimer’s disease (AD), we carried out positron emission…”
Get full text

Inhomogeneous distribution of Alzheimer pathology along the isocortical relief. Are cortical convolutions an Achilles heel of evolution? by Arendt, Thomas, Morawski, Markus, Gärtner, Ulrich, Fröhlich, Nadine, Schulze, Falko, Wohmann, Nils, Jäger, Carsten, Eisenlöffel, Christian, Gertz, Hermann‐Josef, Mueller, Wolf, Brauer, Kurt

“…Alzheimer's disease (AD) is neuropathologically characterized by neuritic plaques and neurofibrillary tangles. Progression of both plaques and tangles…”
Get full text

Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease by Morgen, Katrin, Ramirez, Alfredo, Frölich, Lutz, Tost, Heike, Plichta, Michael M, Kölsch, Heike, Rakebrandt, Fabian, Rienhoff, Otto, Jessen, Frank, Peters, Oliver, Jahn, Holger, Luckhaus, Christian, Hüll, Michael, Gertz, Hermann-Josef, Schröder, Johannes, Hampel, Harald, Teipel, Stefan J, Pantel, Johannes, Heuser, Isabella, Wiltfang, Jens, Rüther, Eckart, Kornhuber, Johannes, Maier, Wolfgang, Meyer-Lindenberg, Andreas

“…Abstract Background Evidence has emerged indicating that the ε4 allele of APOE and PICALM interact in conferring risk of Alzheimer's disease (AD). The biologic…”
Get full text

Memory concerns, memory performance and risk of dementia in patients with mild cognitive impairment by Wolfsgruber, Steffen, Wagner, Michael, Schmidtke, Klaus, Frölich, Lutz, Kurz, Alexander, Schulz, Stefanie, Hampel, Harald, Heuser, Isabella, Peters, Oliver, Reischies, Friedel M, Jahn, Holger, Luckhaus, Christian, Hüll, Michael, Gertz, Hermann-Josef, Schröder, Johannes, Pantel, Johannes, Rienhoff, Otto, Rüther, Eckart, Henn, Fritz, Wiltfang, Jens, Maier, Wolfgang, Kornhuber, Johannes, Jessen, Frank

“…Concerns about worsening memory ("memory concerns"; MC) and impairment in memory performance are both predictors of Alzheimer's dementia (AD). The relationship…”
Get full text

Feasibility and acceptance of simultaneous amyloid PET/MRI by Schütz, Lisa, Lobsien, Donald, Fritzsch, Dominik, Tiepolt, Solveig, Werner, Peter, Schroeter, Matthias L., Berrouschot, Jörg, Saur, Dorothee, Hesse, Swen, Jochimsen, Thies, Rullmann, Michael, Sattler, Bernhard, Patt, Marianne, Gertz, Hermann-Josef, Villringer, Arno, Claßen, Joseph, Hoffmann, Karl-Titus, Sabri, Osama, Barthel, Henryk

“…Purpose Established Alzheimer’s disease (AD) biomarker concepts classify into amyloid pathology and neuronal injury biomarkers, while recent alternative…”
Get full text

Serum lipids and hippocampal volume: The link to Alzheimer's disease? by Wolf, Henrike, Hensel, Anke, Arendt, Thomas, Kivipelto, Miia, Winblad, Bengt, Gertz, Hermann-Josef

“…The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high‐density lipoprotein…”
Get full text

A critical discussion of the role of neuroimaging in mild cognitive impairment by Wolf, Henrike, Jelic, Vesna, Gertz, Hermann-Josef, Nordberg, Agneta, Julin, Per, Wahlund, Lars-Olof

“…Objective – In this paper, the current neuroimaging literature is reviewed with regard to characteristic findings in mild cognitive impairment (MCI)…”
Get full text

Left anterior temporal lobe sustains naming in Alzheimer's dementia and mild cognitive impairment by Frings, Lars, Klöppel, Stefan, Teipel, Stefan, Peters, Oliver, Frölich, Lutz, Pantel, Johannes, Schröder, Johannes, Gertz, Hermann-Josef, Arlt, Sönke, Heuser, Isabella, Kornhuber, Johannes, Wiltfang, Jens, Maier, Wolfgang, Jessen, Frank, Hampel, Harald, Hüll, Michael

“…Cognitive decline in degenerative dementia is paralleled by progressive brain atrophy, with the localization of atrophy reflecting specific cognitive…”
Get more information

Intracranial volume in mild cognitive impairment, Alzheimer's disease and vascular dementia: evidence for brain reserve? by Wolf, Henrike, Julin, Per, Gertz, Hermann-Josef, Winblad, Bengt, Wahlund, Lars-Olof

“…Objective The possibility of brain volume reserve effects was examined in a sample of geriatric outpatients with mild cognitive impairment (MCI), Alzheimer's…”
Get full text

Anosognosia in Alzheimer's disease: the role of impairment levels in assessment of insight across domains by Leicht, Hanna, Berwig, Martin, Gertz, Hermann-Josef

“…Impaired insight for deficits (anosognosia) is common in Alzheimer's disease (AD). However, it has not yet been determined clearly (a) whether different…”
Get more information

Early [18F]florbetaben and [11C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer’s disease by Tiepolt, Solveig, Hesse, Swen, Patt, Marianne, Luthardt, Julia, Schroeter, Matthias L., Hoffmann, Karl-Titus, Weise, David, Gertz, Hermann-Josef, Sabri, Osama, Barthel, Henryk

“…Purpose [ 18 F]FDG is a commonly used neuronal injury biomarker for early and differential diagnosis of dementia. Typically, the blood supply to the brain is…”
Get full text

Quantitative susceptibility mapping in β-Amyloid PET-stratified patients with dementia and healthy controls – A hybrid PET/MRI study by Tiepolt, Solveig, Rullmann, Michael, Jochimsen, Thies H., Gertz, Hermann-Josef, Schroeter, Matthias L., Patt, Marianne, Sabri, Osama, Barthel, Henryk

“…•Clinically diagnosed Alzheimer’s disease patients were stratified by Aβ PET.•Comparison of magnetic susceptibility between Aβ-positive/negative patients and…”
Get full text

Elevated levels of cerebrospinal fluid neuron-specific enolase (NSE) in Alzheimer's disease by Schmidt, Frank Martin, Mergl, Roland, Stach, Barbara, Jahn, Ina, Gertz, Hermann-Josef, Schönknecht, Peter

“…•CSF-NSE was significantly elevated in patients with AD compared to HS.•Diagnostic sensitivity and specificity of CSF-NSE for AD vs. HS were ≥91%.•Accuracy…”
Get full text

The New Modesty: No Big Breakthroughs in Dementia Research, but Some Improvements in Treatment by Gertz, Hermann-Josef

Get full text

CORDIAL: Cognitive Rehabilitation and Cognitive-behavioral Treatment for Early Dementia in Alzheimer Disease: A Multicenter, Randomized, Controlled Trial by KURZ, Alexander, THÖNE-OTTO, Angelika, CRAMER, Barbara, EGERT, Silvia, FRÖLICH, Lutz, GERTZ, Hermann-Josef, KEHL, Victoria, WAGENPFEIL, Stefan, WERHEID, Katja

“…Cognitive rehabilitation (CR) is a promising treatment approach for older adults with dementia because it aims at supporting the management of day-to-day…”
Get full text