Search Results - "Gertler, Tracy"

Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease by Plotkin, Joshua L., Day, Michelle, Peterson, Jayms D., Xie, Zhong, Kress, Geraldine J., Rafalovich, Igor, Kondapalli, Jyothisri, Gertler, Tracy S., Flajolet, Marc, Greengard, Paul, Stavarache, Mihaela, Kaplitt, Michael G., Rosinski, Jim, Chan, C. Savio, Surmeier, D. James

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed…”
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Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons by Gertler, Tracy S, Chan, C. Savio, Surmeier, D. James

“…Principal medium spiny projection neurons (MSNs) of the striatum have long been thought to be homogeneous in their somatodendritic morphology and physiology…”
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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia by Fieblinger, Tim, Graves, Steven M., Sebel, Luke E., Alcacer, Cristina, Plotkin, Joshua L., Gertler, Tracy S., Chan, C. Savio, Heiman, Myriam, Greengard, Paul, Cenci, M. Angela, Surmeier, D. James

“…The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the…”
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A single-center, retrospective analysis of genotype-phenotype correlations in children with Dravet syndrome by Gertler, Tracy S., Calhoun, Jeffrey, Laux, Linda

“…•Pathogenic SCN1A missense variants cluster in specific functional channel domains.•The type of pathogenic SCN1A variant does not impact seizures or…”
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Treatment Responsiveness in KCNT1-Related Epilepsy by Fitzgerald, Mark P., Fiannacca, Martina, Smith, Douglas M., Gertler, Tracy S., Gunning, Boudewijn, Syrbe, Steffen, Verbeek, Nienke, Stamberger, Hannah, Weckhuysen, Sarah, Ceulemans, Berten, Schoonjans, An-Sofie, Rossi, Massimiliano, Demarquay, Geneviève, Lesca, Gaetan, Olofsson, Kern, Koolen, D. A., Hornemann, Frauke, Baulac, Stephanie, Rubboli, Guido, Minks, Kelly Q., Lee, Bohoon, Helbig, Ingo, Dlugos, Dennis, Møller, Rikke S., Bearden, David

“…Pathogenic variants in KCNT1 represent an important cause of treatment-resistant epilepsy, for which an effective therapy has been elusive. Reports about the…”
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KNa1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons by Gertler, Tracy S., Cherian, Suraj, DeKeyser, Jean-Marc, Kearney, Jennifer A., George, Alfred L.

“…KCNT1 encodes the sodium-activated potassium channel KNa1.1, expressed preferentially in the frontal cortex, hippocampus, cerebellum, and brainstem. Pathogenic…”
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Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex by Schaefer, Anne, Sampath, Srihari C., Intrator, Adam, Min, Alice, Gertler, Tracy S., Surmeier, D. James, Tarakhovsky, Alexander, Greengard, Paul

“…The genetic basis of cognition and behavioral adaptation to the environment remains poorly understood. Here we demonstrate that the histone methyltransferase…”
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Corrigendum to “A single-center, retrospective analysis of genotype–phenotype correlations in children with Dravet syndrome” [Seizure: Eur. J. Epilepsy 75 (2020) 1–6] by Gertler, Tracy S., Calhoun, Jeffrey, Laux, Linda

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Bringing nutritional ketosis to the table as an option for healing the pediatric brain by Gertler, Tracy S, Blackford, Robyn

“…Our core premise is that personalized variations of a ketogenic diet are likely to benefit pediatric patients with neuropsychiatric symptoms across multiple…”
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Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures by Lu, Shenzhao, Hernan, Rebecca, Marcogliese, Paul C., Huang, Yan, Gertler, Tracy S., Akcaboy, Meltem, Liu, Shiyong, Chung, Hyung-lok, Pan, Xueyang, Sun, Xiaoqin, Oguz, Melahat Melek, Oztoprak, Ulkühan, de Baaij, Jeroen H.F., Ivanisevic, Jelena, McGinnis, Erin, Guillen Sacoto, Maria J., Chung, Wendy K., Bellen, Hugo J.

“…TIAM Rac1-associated GEF 1 (TIAM1) regulates RAC1 signaling pathways that affect the control of neuronal morphogenesis and neurite outgrowth by modulating the…”
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Pearls & Oy-sters: When Genetic Generalized Epilepsy Becomes Progressive by Purushothaman, Priya, McGinnis, Erin M., Aldulescu, Monica, Stack, Cynthia V., Gertler, Tracy S.

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Calcium homeostasis, selective vulnerability and Parkinson's disease by Chan, C. Savio, Gertler, Tracy S, Surmeier, D. James

“…Parkinson's disease (PD) is a common neurodegenerative disorder of which the core motor symptoms are attributable to the degeneration of dopamine (DA) neurons…”
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HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease by Surmeier, D James, Chan, C Savio, Glajch, Kelly E, Gertler, Tracy S, Guzman, Jaime N, Mercer, Jeff N, Lewis, Alan S, Goldberg, Alan B, Tkatch, Tatiana, Shigemoto, Ryuichi, Fleming, Sheila M, Chetkovich, Dane M, Osten, Pavel, Kita, Hitoshi

“…Using a rat model of PD, the authors find a progressive decline in autonomous globus pallidus pacemaking. This loss was reversed by viral expression of the HCN…”
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Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell–Derived Neurons by Parnell, Euan, Culotta, Lorenza, Forrest, Marc P., Jalloul, Hiba A., Eckman, Blair L., Loizzo, Daniel D., Horan, Katherine K.E., Dos Santos, Marc, Piguel, Nicolas H., Tai, Derek J.C., Zhang, Hanwen, Gertler, Tracy S., Simkin, Dina, Sanders, Alan R., Talkowski, Michael E., Gejman, Pablo V., Kiskinis, Evangelos, Duan, Jubao, Penzes, Peter

“…Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely…”
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A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease by Chan, C. Savio, Gertler, Tracy S., Surmeier, D. James

“…Parkinson's disease (PD) is a common neurodegenerative disorder of unknown etiology. There is no cure or proven strategy for slowing the progression of the…”
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Screening of conventional anticonvulsants in a genetic mouse model of epilepsy by Hawkins, Nicole A., Anderson, Lyndsey L., Gertler, Tracy S., Laux, Linda, George, Alfred L., Kearney, Jennifer A.

“…Objective Epilepsy is a common neurological disorder that affects 1% of the population. Approximately, 30% of individuals with epilepsy are refractory to…”
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Monoallelic and biallelic mutations in RELN underlie a graded series of neurodevelopmental disorders by Di Donato, Nataliya, Guerrini, Renzo, Billington, Charles J, Barkovich, A James, Dinkel, Philine, Freri, Elena, Heide, Michael, Gershon, Elliot S, Gertler, Tracy S, Hopkin, Robert J, Jacob, Suma, Keedy, Sarah K, Kooshavar, Daniz, Lockhart, Paul J, Lohmann, Dietmar R, Mahmoud, Iman G, Parrini, Elena, Schrock, Evelin, Severi, Giulia, Timms, Andrew E, Webster, Richard I, Willis, Mary J H, Zaki, Maha S, Gleeson, Joseph G, Leventer, Richard J, Dobyns, William B

“…Reelin, a large extracellular protein, plays several critical roles in brain development and function. It is encoded by RELN, first identified as the gene…”
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SCN8A: When Neurons Are So Excited, They Just Can’t Hide It by Gertler, Tracy S., Carvill, Gemma L.

“…Prominent role of forebrain excitatory neurons in SCN8A encephalopathy. Bunton-Stasyshyn RKA, Wagnon JL, Wengert ER, Barker BS, Faulkner A, Wagley PK, Bhatia…”
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Hypoglycemia in Infants and Effect on Neurodevelopment by McGowan, Bridget R, Gertler, Tracy S

“…In a prospective, randomized treatment trial, investigators from multiple institutions in the HypoEXIT Study Group investigated the developmental outcomes…”
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The role of dopamine in modulating the structure and function of striatal circuits by Surmeier, D James, Shen, Weixing, Day, Michelle, Gertler, Tracy, Chan, Savio, Tian, Xianyong, Plotkin, Joshua L

“…Dopamine (DA) is a key regulator of action selection and associative learning. The striatum has long been thought to be a major locus of DA action in this…”
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