Search Results - "Gertler, S."

Tacit knowledge and the economic geography of context, or The undefinable tacitness of being (there) by Gertler, Meric S.

“…Within economic geography and industrial economics, interest in the concept of tacit knowledge has grown steadily in recent years. Nelson and Winter helped…”
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Impaired TrkB Receptor Signaling Underlies Corticostriatal Dysfunction in Huntington’s Disease by Plotkin, Joshua L., Day, Michelle, Peterson, Jayms D., Xie, Zhong, Kress, Geraldine J., Rafalovich, Igor, Kondapalli, Jyothisri, Gertler, Tracy S., Flajolet, Marc, Greengard, Paul, Stavarache, Mihaela, Kaplitt, Michael G., Rosinski, Jim, Chan, C. Savio, Surmeier, D. James

“…Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder. The debilitating choreic movements that plague HD patients have been attributed…”
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Dichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons by Gertler, Tracy S, Chan, C. Savio, Surmeier, D. James

“…Principal medium spiny projection neurons (MSNs) of the striatum have long been thought to be homogeneous in their somatodendritic morphology and physiology…”
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Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia by Fieblinger, Tim, Graves, Steven M., Sebel, Luke E., Alcacer, Cristina, Plotkin, Joshua L., Gertler, Tracy S., Chan, C. Savio, Heiman, Myriam, Greengard, Paul, Cenci, M. Angela, Surmeier, D. James

“…The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson’s disease (PD) and L-DOPA-induced dyskinesia (LID). In these disease states, the…”
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KNa1.1 gain-of-function preferentially dampens excitability of murine parvalbumin-positive interneurons by Gertler, Tracy S., Cherian, Suraj, DeKeyser, Jean-Marc, Kearney, Jennifer A., George, Alfred L.

“…KCNT1 encodes the sodium-activated potassium channel KNa1.1, expressed preferentially in the frontal cortex, hippocampus, cerebellum, and brainstem. Pathogenic…”
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Local Nodes in Global Networks: The Geography of Knowledge Flows in Biotechnology Innovation by Gertler, M. S., Levitte, Y. M.

“…The literature on innovation and interactive learning has tended to emphasize the importance of local networks, inter-firm collaboration and knowledge flows as…”
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Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex by Schaefer, Anne, Sampath, Srihari C., Intrator, Adam, Min, Alice, Gertler, Tracy S., Surmeier, D. James, Tarakhovsky, Alexander, Greengard, Paul

“…The genetic basis of cognition and behavioral adaptation to the environment remains poorly understood. Here we demonstrate that the histone methyltransferase…”
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Bringing nutritional ketosis to the table as an option for healing the pediatric brain by Gertler, Tracy S, Blackford, Robyn

“…Our core premise is that personalized variations of a ketogenic diet are likely to benefit pediatric patients with neuropsychiatric symptoms across multiple…”
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Smoldering myocarditis following immune checkpoint blockade by Norwood, Timothy G, Westbrook, Brian C, Johnson, Douglas B, Litovsky, Silvio H, Terry, Nina L, McKee, Svetlana B, Gertler, Alan S, Moslehi, Javid J, Conry, Robert M

“…Severe myocarditis associated with electrical conduction abnormalities and occasionally heart failure has been well documented following treatment with immune…”
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Calcium homeostasis, selective vulnerability and Parkinson's disease by Chan, C. Savio, Gertler, Tracy S, Surmeier, D. James

“…Parkinson's disease (PD) is a common neurodegenerative disorder of which the core motor symptoms are attributable to the degeneration of dopamine (DA) neurons…”
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Clusters from the Inside and Out: Local Dynamics and Global Linkages by Wolfe, David A., Gertler, Meric S.

“…This paper surveys some of the current methodologies employed to analyse cluster development, as well as some of the key themes emerging from both the…”
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Selective loss of bi-directional synaptic plasticity in the direct and indirect striatal output pathways accompanies generation of parkinsonism and l -DOPA induced dyskinesia in mouse models by Thiele, Sherri L, Chen, Betty, Lo, Charlotte, Gertler, Tracey S, Warre, Ruth, Surmeier, James D, Brotchie, Jonathan M, Nash, Joanne E

“…Abstract Parkinsonian symptoms arise due to over-activity of the indirect striatal output pathway, and under-activity of the direct striatal output pathway. l…”
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Double-Blind, Randomized Trial Comparing the Efficacy and Tolerability of Fulvestrant Versus Anastrozole in Postmenopausal Women With Advanced Breast Cancer Progressing on Prior Endocrine Therapy: Results of a North American Trial by OSBORNE, C. K, PIPPEN, J, WEBSTER, A, MORRIS, C, ELLEDGE, R, BUZDAR, A, JONES, S. E, PARKER, L. M, ELLIS, M, COME, S, GERTLER, S. Z, MAY, J. T, BURTON, G, DIMERY, I

“…To compare the efficacy and tolerability of fulvestrant (formerly ICI 182,780) with anastrozole in the treatment of advanced breast cancer in patients whose…”
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HCN channelopathy in external globus pallidus neurons in models of Parkinson's disease by Surmeier, D James, Chan, C Savio, Glajch, Kelly E, Gertler, Tracy S, Guzman, Jaime N, Mercer, Jeff N, Lewis, Alan S, Goldberg, Alan B, Tkatch, Tatiana, Shigemoto, Ryuichi, Fleming, Sheila M, Chetkovich, Dane M, Osten, Pavel, Kita, Hitoshi

“…Using a rat model of PD, the authors find a progressive decline in autonomous globus pallidus pacemaking. This loss was reversed by viral expression of the HCN…”
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Preference weights for chemotherapy side effects from the perspective of women with breast cancer by Kuchuk, I., Bouganim, N., Beusterien, K., Grinspan, J., Vandermeer, L., Gertler, S., Dent, S. F., Song, X., Segal, R., Mazzarello, S., Crawley, F., Dranitsaris, G., Clemons, M.

“…Perceptions among women with breast cancer about the relative importance of different potential chemotherapy side effects is not well understood. A survey was…”
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Screening of conventional anticonvulsants in a genetic mouse model of epilepsy by Hawkins, Nicole A., Anderson, Lyndsey L., Gertler, Tracy S., Laux, Linda, George, Alfred L., Kearney, Jennifer A.

“…Objective Epilepsy is a common neurological disorder that affects 1% of the population. Approximately, 30% of individuals with epilepsy are refractory to…”
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Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice by Chan, C Savio, Peterson, Jayms D, Gertler, Tracy S, Glajch, Kelly E, Quintana, Ruth E, Cui, Qiaoling, Sebel, Luke E, Plotkin, Joshua L, Shen, Weixing, Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Surmeier, D James

“…Mice carrying bacterial artificial chromosome (BAC) transgenes have become important tools for neuroscientists, providing a powerful means of dissecting…”
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Perceptions of vascular access for intravenous systemic therapy and risk factors for lymphedema in early-stage breast cancer-a patient survey by LeVasseur, N, Stober, C, Ibrahim, M, Gertler, S, Hilton, J, Robinson, A, McDiarmid, S, Fergusson, D, Mazzarello, S, Hutton, B, Joy, A A, McInnes, M, Clemons, M

“…The choice of vascular access for systemic therapy administration in breast cancer remains an area of clinical equipoise, and patient preference is not…”
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Functional consequences of a KCNT1 variant associated with status dystonicus and early‐onset infantile encephalopathy by Gertler, Tracy S., Thompson, Christopher H., Vanoye, Carlos G., Millichap, John J., George, Alfred L.

“…Objective We identified a novel de novo KCNT1 variant in a patient with early‐infantile epileptic encephalopathy (EIEE) and status dystonicus, a…”
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Creatives after the crash by Donald, B., Gertler, M. S., Tyler, P.

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