Search Results - "Gertler, Frank"

Tks5 and SHIP2 Regulate Invadopodium Maturation, but Not Initiation, in Breast Carcinoma Cells by Sharma, Ved P., Eddy, Robert, Entenberg, David, Kai, Masayuki, Gertler, Frank B., Condeelis, John

“…Tks5 regulates invadopodium formation, but the precise timing during invadopodium lifetime (initiation, stabilization, maturation) when Tks5 plays a role is…”
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Distal Alternative Last Exons Localize mRNAs to Neural Projections by Taliaferro, J. Matthew, Vidaki, Marina, Oliveira, Ruan, Olson, Sara, Zhan, Lijun, Saxena, Tanvi, Wang, Eric T., Graveley, Brenton R., Gertler, Frank B., Swanson, Maurice S., Burge, Christopher B.

“…Spatial restriction of mRNA to distinct subcellular locations enables local regulation and synthesis of proteins. However, the organizing principles of mRNA…”
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An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype by Shapiro, Irina M, Cheng, Albert W, Flytzanis, Nicholas C, Balsamo, Michele, Condeelis, John S, Oktay, Maja H, Burge, Christopher B, Gertler, Frank B

“…Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation. While much is…”
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Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function by Zervantonakis, Ioannis K, Hughes-Alford, Shannon K, Charest, Joseph L, Condeelis, John S, Gertler, Frank B, Kamm, Roger D

“…Entry of tumor cells into the blood stream is a critical step in cancer metastasis. Although significant progress has been made in visualizing tumor cell…”
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Ena/VASP: towards resolving a pointed controversy at the barbed end by Bear, James E, Gertler, Frank B

“…Ena/VASP proteins are conserved regulators of actin dynamics that have important roles in several physiological processes such as morphogenesis, axon guidance,…”
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Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes by Rohani, Nazanin, Hao, Liangliang, Alexis, Maria S, Joughin, Brian A, Krismer, Konstantin, Moufarrej, Mira N, Soltis, Anthony R, Lauffenburger, Douglas A, Yaffe, Michael B, Burge, Christopher B, Bhatia, Sangeeta N, Gertler, Frank B

“…Acidosis is a fundamental feature of the tumor microenvironment, which directly regulates tumor cell invasion by affecting immune cell function, clonal cell…”
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The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells by Meyer, Aaron S, Miller, Miles A, Gertler, Frank B, Lauffenburger, Douglas A

“…The relationship between drug resistance, changes in signaling, and emergence of an invasive phenotype is well appreciated, but the underlying mechanisms are…”
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Integrin Signaling Switches the Cytoskeletal and Exocytic Machinery that Drives Neuritogenesis by Gupton, Stephanie L., Gertler, Frank B.

“…Neurons establish their unique morphology by elaborating multiple neurites that subsequently form axons and dendrites. Neurite initiation entails significant…”
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Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions by Puleo, Julieann I, Parker, Sara S, Roman, Mackenzie R, Watson, Adam W, Eliato, Kiarash Rahmani, Peng, Leilei, Saboda, Kathylynn, Roe, Denise J, Ros, Robert, Gertler, Frank B, Mouneimne, Ghassan

“…The mechanical properties of a cell's microenvironment influence many aspects of cellular behavior, including cell migration. Durotaxis, the migration toward…”
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The growth cone cytoskeleton in axon outgrowth and guidance by Dent, Erik W, Gupton, Stephanie L, Gertler, Frank B

“…Axon outgrowth and guidance to the proper target requires the coordination of filamentous (F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers…”
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Differential Remodeling of Actin Cytoskeleton Architecture by Profilin Isoforms Leads to Distinct Effects on Cell Migration and Invasion by Mouneimne, Ghassan, Hansen, Scott D., Selfors, Laura M., Petrak, Lara, Hickey, Michele M., Gallegos, Lisa L., Simpson, Kaylene J., Lim, James, Gertler, Frank B., Hartwig, John H., Mullins, R. Dyche, Brugge, Joan S.

“…Dynamic actin cytoskeletal reorganization is integral to cell motility. Profilins are well-characterized regulators of actin polymerization; however,…”
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Microenvironment-triggered multimodal precision diagnostics by Hao, Liangliang, Rohani, Nazanin, Zhao, Renee T., Pulver, Emilia M., Mak, Howard, Kelada, Olivia J., Ko, Henry, Fleming, Heather E., Gertler, Frank B., Bhatia, Sangeeta N.

“…Therapeutic outcomes in oncology may be aided by precision diagnostics that offer early detection, localization and the opportunity to monitor response to…”
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Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination by ROBINSON, Brian D, SICA, Gabriel L, LIU, Yi-Fang, ROHAN, Thomas E, GERTLER, Frank B, CONDEELIS, John S, JONES, Joan G

“…Purpose: Multiphoton-based intravital imaging has shown that invasive carcinoma cells in mouse and rat mammary tumors intravasate when associated with…”
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Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway by Kumari, Sudha, Depoil, David, Martinelli, Roberta, Judokusumo, Edward, Carmona, Guillaume, Gertler, Frank B, Kam, Lance C, Carman, Christopher V, Burkhardt, Janis K, Irvine, Darrell J, Dustin, Michael L

“…Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell…”
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Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression by Oudin, Madeleine J, Jonas, Oliver, Kosciuk, Tatsiana, Broye, Liliane C, Guido, Bruna C, Wyckoff, Jeff, Riquelme, Daisy, Lamar, John M, Asokan, Sreeja B, Whittaker, Charlie, Ma, Duanduan, Langer, Robert, Cima, Michael J, Wisinski, Kari B, Hynes, Richard O, Lauffenburger, Douglas A, Keely, Patricia J, Bear, James E, Gertler, Frank B

“…Fibronectin (FN) is a major component of the tumor microenvironment, but its role in promoting metastasis is incompletely understood. Here, we show that FN…”
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Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice by Klapproth, Sarah, Sperandio, Markus, Pinheiro, Elaine M., Prünster, Monika, Soehnlein, Oliver, Gertler, Frank B., Fässler, Reinhard, Moser, Markus

“…Talin is an integrin adaptor, which controls integrin activity in all hematopoietic cells. How intracellular signals promote talin binding to the integrin tail…”
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Ena/VASP: proteins at the tip of the nervous system by Drees, Frauke, Gertler, Frank B

“…The emergence of neurites from a symmetrical cell body is an essential feature of nervous system development. Neurites are the precursors of axons and…”
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Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function by Barzik, Melanie, McClain, Leslie M, Gupton, Stephanie L, Gertler, Frank B

“…Filopodia are long plasma membrane extensions involved in the formation of adhesive, contractile, and protrusive actin-based structures in spreading and…”
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Rap1 and its effector RIAM are required for lymphocyte trafficking by Su, Wenjuan, Wynne, Joseph, Pinheiro, Elaine M., Strazza, Marianne, Mor, Adam, Montenont, Emilie, Berger, Jeffrey, Paul, David S., Bergmeier, Wolfgang, Gertler, Frank B., Philips, Mark R.

“…Regulation of integrins is critical for lymphocyte adhesion to endothelium and trafficking through secondary lymphoid organs. Inside-out signaling to integrins…”
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Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer by Rohan, Thomas E, Xue, Xiaonan, Lin, Hung-Mo, D'Alfonso, Timothy M, Ginter, Paula S, Oktay, Maja H, Robinson, Brian D, Ginsberg, Mindy, Gertler, Frank B, Glass, Andrew G, Sparano, Joseph A, Condeelis, John S, Jones, Joan G

“…Tumor microenvironment of metastasis (TMEM), consisting of direct contact between a macrophage, an endothelial cell, and a tumor cell, has been associated with…”
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