Search Results - "Gershanik, Oscar S."

Improving l-dopa therapy: The development of enzyme inhibitors by Gershanik, Oscar S.

“…ABSTRACT The introduction of levodopa produced a monumental change in the treatment of Parkinson's disease (PD). Limitations in its bioavailability and…”
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Postural deformities in Parkinson's disease by Doherty, Karen M, MRCP, van de Warrenburg, Bart P, MD, Peralta, Maria Cecilia, MD, Silveira-Moriyama, Laura, PhD, Azulay, Jean-Philippe, Prof, Gershanik, Oscar S, MD, Bloem, Bastiaan R, Prof

“…Summary Postural deformities are frequent and disabling complications of Parkinson's disease (PD) and atypical parkinsonism. These deformities include…”
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Does Parkinson's disease start in the gut? by Gershanik, Oscar S

“…Current understanding of the pathophysiology of Parkinson's disease suggests a key role of the accumulation of alpha-synuclein in the pathogenesis. This…”
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Screening for idiopathic REM sleep behavior disorder: usefulness of actigraphy by Stefani, Ambra, Heidbreder, Anna, Brandauer, Elisabeth, Guaita, Marc, Neier, Lisa-Marie, Mitterling, Thomas, Santamaria, Joan, Iranzo, Alex, Videnovic, Aleksander, Trenkwalder, Claudia, Sixel-Döring, Friederike, Wenning, Gregor K, Chade, Anabel, Poewe, Werner, Gershanik, Oscar S, Högl, Birgit

“…Abstract Study Objectives To evaluate the utility of multimodal low-cost approaches including actigraphy, a wrist-worn device monitoring rest/activity cycles,…”
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Past, present, and future of Parkinson's disease by Gershanik, Oscar S.

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Unanswered Questions in Clinical Practice by Lynch, Tim, S Gershanik, Oscar

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Cabergoline and pramipexole fail to modify already established dyskinesias in an animal model of parkinsonism by Larramendy, Celia, Taravini, Irene R.E., Saborido, Mariano D., Ferrario, Juan E., Murer, Mario G., Gershanik, Oscar S.

“…Levodopa-induced dyskinesias are one of the major limiting side effects encountered in the treatment of Parkinson's disease. Dopamine agonists of the D2 family…”
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Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats by Taravini, Irene Re, Chertoff, Mariela, Cafferata, Eduardo G, Courty, José, Murer, Mario G, Pitossi, Fernando J, Gershanik, Oscar S

“…Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's…”
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Dancing Dorsal Quadrilaterals: A Novel Peripherally Induced Movement Disorder by Lizarraga, Karlo J, Thompson, Philip D, Moore, Henry P, Mizraji, Gabriel, Gershanik, Oscar S, Singer, Carlos, Lang, Anthony E

“…Recognized peripherally induced movement disorders include the painful legs moving toes syndrome, postamputation dyskinesias, and belly dancer dyskinesias. To…”
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Clinical problems in late-stage Parkinson’s disease by Gershanik, Oscar S.

“…Advanced Parkinson’s disease patients require for their care the participation of a multidisciplinary team. Particularly in the late stages of the disease,…”
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Subjective visual vertical in Pisa syndrome by Scocco, Darío H, Wagner, Judith N, Racosta, Juan, Chade, Anabel, Gershanik, Oscar S

“…Abstract Background Parkinson's Disease (PD) alters perception and somatosensory information integration, including visual dependency and judgment of body…”
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The Kinase Fyn As a Novel Intermediate in l-DOPA-Induced Dyskinesia in Parkinson’s Disease by Sanz-Blasco, Sara, Bordone, Melina P., Damianich, Ana, Gomez, Gimena, Bernardi, M. Alejandra, Isaja, Luciana, Taravini, Irene R., Hanger, Diane P., Avale, M. Elena, Gershanik, Oscar S., Ferrario, Juan E.

“…Dopamine replacement therapy with l -DOPA is the treatment of choice for Parkinson’s disease; however, its long-term use is frequently associated with l…”
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Regulation of Pleiotrophin and Fyn in the striatum of rats undergoing L-DOPA-induced dyskinesia by Gomez, Gimena, Saborido, Mariano D., Bernardi, M. Alejandra, Gershanik, Oscar S., Taravini, Irene R., Ferrario, Juan E.

“…•Striatal Pleiotrophin immunodetection is increased in L-DOPA induced dyskinesias.•Total amounts of the kinase Fyn are unchanged by 6-OHDA lesion or…”
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Stiff-person syndrome by Gershanik, Oscar S

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Contrasting gene expression patterns induced by levodopa and pramipexole treatments in the rat model of Parkinson's disease by Taravini, Irene R., Larramendy, Celia, Gomez, Gimena, Saborido, Mariano D., Spaans, Floor, Fresno, Cristóbal, González, Germán A., Fernández, Elmer, Murer, Mario G., Gershanik, Oscar S.

“…Whether the treatment of Parkinson's disease has to be initiated with levodopa or a D2 agonist like pramipexole remains debatable. Levodopa is more potent…”
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Highlights of the Stockholm Congress: A Clinician's Perspective by Gershanik, Oscar S.

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Effects of orally administered levodopa on mesencephalic dopaminergic neurons undergoing a degenerative process by Ferrario, Juan E., Delfino, Marina A., Stefano, Andrea V., Zbarsky, Virginia, Douhou, Aicha, Murer, M.Gustavo, Raisman-Vozari, Rita, Gershanik, Oscar S.

“…Although the issue of in vivo levodopa toxicity appears to be settled by now in the light of recent findings, a crucial aspect was not accounted for the…”
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A Functional Parkinsonian Tremor in a Pediatric Patient by Sanchez Abraham, Marina, Gomez Arevalo, Gonzalo J., Garcia, Silvia S., Gershanik, Oscar S.

“…View Supplementary Video 1…”
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Typical and atypical neuroleptics by Gershanik, Oscar S, Gómez Arévalo, Gonzalo J

“…Neuroleptics having dopamine receptor-blocking properties are frequently responsible for the development of movement disorders. This has been known for many…”
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Mapping the Effects of Three Dopamine Agonists with Different Dyskinetogenic Potential and Receptor Selectivity Using Pharmacological Functional Magnetic Resonance Imaging by DELFINO, Marina, KALISCH, Raffael, CZISCH, Michael, LARRAMENDY, Celia, RICATTI, Jimena, TARAVINI, Irene R. E, TRENKWALDER, Claudia, GUSTAVO MURER, Mario, AUER, Dorothee P, GERSHANIK, Oscar S

“…The mechanisms underlying dopamine agonist-induced dyskinesia in Parkinson's disease remain poorly understood. Similar to patients, rats with severe…”
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