Search Results - "Gerrit J. Bouma"

The Role of LIN28- let-7 -ARID3B Pathway in Placental Development by Ali, Asghar, Bouma, Gerrit J, Anthony, Russell V, Winger, Quinton A

“…Placental disorders are a major cause of pregnancy loss in humans, and 40-60% of embryos are lost between fertilization and birth. Successful embryo…”
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The Roles of Extracellular Vesicles and Organoid Models in Female Reproductive Physiology by Thompson, Riley E, Bouma, Gerrit J, Hollinshead, Fiona K

“…Culture model systems that can recapitulate the anatomy and physiology of reproductive organs, such as three-dimensional (3D) organoid culture systems, limit…”
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MicroRNA-mRNA Networks in Pregnancy Complications: A Comprehensive Downstream Analysis of Potential Biomarkers by Ali, Asghar, Hadlich, Frieder, Abbas, Muhammad W, Iqbal, Muhammad A, Tesfaye, Dawit, Bouma, Gerrit J, Winger, Quinton A, Ponsuksili, Siriluck

“…Pregnancy complications are a major cause of fetal and maternal morbidity and mortality in humans. The majority of pregnancy complications initiate due to…”
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LIN28‐let‐7 axis regulates genes in immortalized human trophoblast cells by targeting the ARID3B‐complex by Ali, Asghar, Anthony, Russell V., Bouma, Gerrit J., Winger, Quinton A.

“…Abnormal placental development is one of the main etiological factors for intrauterine growth restriction (IUGR). Here, we show that LIN28A and LIN28B are…”
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Cell-secreted vesicles containing microRNAs as regulators of gamete maturation by da Silveira, Juliano C, de Ávila, Ana Clara F C M, Garrett, Hannah L, Bruemmer, Jason E, Winger, Quinton A, Bouma, Gerrit J

“…Mammalian gamete maturation requires extensive signaling between germ cells and their surrounding somatic cells. In the ovary, theca cells, mural granulosa…”
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Regulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare by da Silveira, Juliano C, Carnevale, Elaine M, Winger, Quinton A, Bouma, Gerrit J

“…Ovarian follicle growth and maturation requires extensive communication between follicular somatic cells and oocytes. Recently, intercellular cell…”
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Shifting perspectives from "oncogenic" to oncofetal proteins; how these factors drive placental development by West, Rachel C, Bouma, Gerrit J, Winger, Quinton A

“…Early human placental development strongly resembles carcinogenesis in otherwise healthy tissues. The progenitor cells of the placenta, the cytotrophoblast,…”
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Corticotropin releasing hormone is present in the feline placenta and maternal serum by Watt, Madison, Mohammadzadeh, Pardis, Pinsinski, Emma, Hollinshead, Fiona K, Bouma, Gerrit J

“…In women, placental corticotropin releasing hormone (CRH) can be detected in maternal blood throughout pregnancy and is important in the regulation of the…”
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Trophectoderm-Specific Knockdown of LIN28 Decreases Expression of Genes Necessary for Cell Proliferation and Reduces Elongation of Sheep Conceptus by Ali, Asghar, Stenglein, Mark D, Spencer, Thomas E, Bouma, Gerrit J, Anthony, Russell V, Winger, Quinton A

“…LIN28 inhibits miRNA maturation which prevents cell differentiation and promotes proliferation. We hypothesized that the LIN28- axis regulates…”
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Identification of microRNAs in exosomes isolated from serum and umbilical cord blood, as well as placentomes of gestational day 90 pregnant sheep by Cleys, Ellane R., Halleran, Jennifer L., McWhorter, Erin, Hergenreder, Joanna, Enriquez, Vanessa A., da Silveira, Juliano C., Bruemmer, Jason E., Winger, Quinton A., Bouma, Gerrit J.

“…SUMMARY Despite reports that circulating levels of maternal serum exosomes increase during pregnancy and that placenta‐specific microRNAs (miRNAs) have been…”
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Maternal Influenza A Virus Infection Restricts Fetal and Placental Growth and Adversely Affects the Fetal Thymic Transcriptome by Van Campen, Hana, Bishop, Jeanette V, Abrahams, Vikki M, Bielefeldt-Ohmann, Helle, Mathiason, Candace K, Bouma, Gerrit J, Winger, Quinton A, Mayo, Christie E, Bowen, Richard A, Hansen, Thomas R

“…Maternal influenza A viral infections in humans are associated with low birth weight, increased risk of pre-term birth, stillbirth and congenital defects. To…”
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Androgen receptor and histone lysine demethylases in ovine placenta by Cleys, Ellane R, Halleran, Jennifer L, Enriquez, Vanessa A, da Silveira, Juliano C, West, Rachel C, Winger, Quinton A, Anthony, Russell V, Bruemmer, Jason E, Clay, Colin M, Bouma, Gerrit J

“…Sex steroid hormones regulate developmental programming in many tissues, including programming gene expression during prenatal development. While estradiol is…”
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Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice by Bouma, Gerrit J, Washburn, Linda L, Albrecht, Kenneth H, Eicher, Eva M

“…Previous reports suggested that humans and mice differ in their sensitivity to the genetic dosage of transcription factors that play a role in early testicular…”
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Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation by Torley, Katie J, da Silveira, Juliano C, Smith, Peter, Anthony, Russell V, Veeramachaneni, D N Rao, Winger, Quinton A, Bouma, Gerrit J

“…Gonadal differentiation in the mammalian fetus involves a complex dose-dependent genetic network. Initiation and progression of fetal ovarian and testicular…”
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MicroRNA Expression Changes and Integrated Pathways Associated With Poor Outcome in Canine Osteosarcoma by Dailey, Deanna D, Hess, Ann M, Bouma, Gerrit J, Duval, Dawn L

“…MicroRNAs (miRNA) are small non-coding RNA molecules involved in post-transcriptional gene regulation. Deregulation of miRNA expression occurs in cancer, and…”
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Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway by Correa, Stephanie M, Washburn, Linda L, Kahlon, Ravi S, Musson, Michelle C, Bouma, Gerrit J, Eicher, Eva M, Albrecht, Kenneth H

“…Sex reversal can occur in XY humans with only a single functional WT1 or SF1 allele or a duplication of the chromosome region containing WNT4. In contrast, XY…”
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Trophectoderm Transcriptome Analysis in LIN28 Knockdown Ovine Conceptuses Suggests Diverse Roles of the LIN28-let-7 Axis in Placental and Fetal Development by Ali, Asghar, Iqbal, Muhammad A, Abbas, Muhammad W, Bouma, Gerrit J, Anthony, Russell V, Spencer, Thomas E, Winger, Quinton A

“…The proper conceptus elongation in ruminants is critical for the successful placentation and establishment of pregnancy. We have previously shown that the…”
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Orthogonal polarization spectral imaging: A new method for study of the microcirculation by Nadeau, Richard G, Groner, Warren, Winkelman, James W, Harris, Anthony G, Ince, Can, Bouma, Gerrit J, Messmer, Konrad

“…Different disease states, including diabetes, hypertension and coronary heart disease, produce distinctive microvascular pathologies. So far, imaging of the…”
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New Candidate Genes Identified for Controlling Mouse Gonadal Sex Determination and the Early Stages of Granulosa and Sertoli Cell Differentiation by Bouma, Gerrit J, Hudson, Quanah J, Washburn, Linda L, Eicher, Eva M

“…Mammalian gonadal sex-determining (GSD) genes are expressed in a unique population of somatic cells that differentiate into granulosa cells in XX gonads or…”
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Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells by Bouma, Gerrit J, Albrecht, Kenneth H, Washburn, Linda L, Recknagel, Andrew K, Churchill, Gary A, Eicher, Eva M

“…The nuclear receptor transcription factor Dax1 is hypothesized to play a role in testicular development, although the mechanism of its action is unknown. Here,…”
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