Search Results - "Gerondopoulos, Andreas"

Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor by Bräuer, Philipp, Parker, Joanne L, Gerondopoulos, Andreas, Zimmermann, Iwan, Seeger, Markus A, Barr, Francis A, Newstead, Simon

“…Selective export and retrieval of proteins between the endoplasmic reticulum (ER) and Golgi apparatus is indispensable for eukaryotic cell function. An…”
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Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors by Yoshimura, Shin-ichiro, Gerondopoulos, Andreas, Linford, Andrea, Rigden, Daniel J, Barr, Francis A

“…A key requirement for Rab function in membrane trafficking is site-specific activation by GDP-GTP exchange factors (GEFs), but the majority of the 63 human…”
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Rab18 and a Rab18 GEF complex are required for normal ER structure by Gerondopoulos, Andreas, Bastos, Ricardo Nunes, Yoshimura, Shin-Ichiro, Anderson, Rachel, Carpanini, Sarah, Aligianis, Irene, Handley, Mark T, Barr, Francis A

“…The ancestral Rab GTPase Rab18 and both subunits of the Rab3GAP complex are mutated in the human neurological and developmental disorder Warburg Micro…”
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A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval by Gerondopoulos, Andreas, Bräuer, Philipp, Sobajima, Tomoaki, Wu, Zhiyi, Parker, Joanne L, Biggin, Philip, Barr, Francis A, Newstead, Simon

“…ER proteins of widely differing abundance are retrieved from the Golgi by the KDEL-receptor. Abundant ER proteins tend to have KDEL rather than HDEL signals,…”
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Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex by Gerondopoulos, Andreas, Strutt, Helen, Stevenson, Nicola L., Sobajima, Tomoaki, Levine, Tim P., Stephens, David J., Strutt, David, Barr, Francis A.

“…A subset of Rab GTPases have been implicated in cilium formation in cultured mammalian cells [1–6]. Rab11 and Rab8, together with their GDP-GTP exchange…”
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Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells by Linford, Andrea, Yoshimura, Shin-ichiro, Bastos, Ricardo Nunes, Langemeyer, Lars, Gerondopoulos, Andreas, Rigden, Daniel J., Barr, Francis A.

“…Rab GTPases define the vesicle trafficking pathways underpinning cell polarization and migration. Here, we find that Rab4, Rab11, and Rab14 and the candidate…”
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Calicivirus translation initiation requires an interaction between VPg and eIF4E by Goodfellow, Ian, Chaudhry, Yasmin, Gioldasi, Ioanna, Gerondopoulos, Andreas, Natoni, Alessandro, Labrie, Louisette, Laliberté, Jean-François, Roberts, Lisa

“…Unlike other positive‐stranded RNA viruses that use either a 5′‐cap structure or an internal ribosome entry site to direct translation of their messenger RNA,…”
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Cellular localization, accumulation and trafficking of double-walled carbon nanotubes in human prostate cancer cells by Neves, Vera, Gerondopoulos, Andreas, Heister, Elena, Tîlmaciu, Carmen, Flahaut, Emmanuel, Soula, B., Silva, S. Ravi P., McFadden, Johnjoe, Coley, Helen M.

“…Carbon nanotubes (CNTs) are at present being considered as potential nanovectors with the ability to deliver therapeutic cargoes into living cells. Previous…”
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BLOC-3 Mutated in Hermansky-Pudlak Syndrome Is a Rab32/38 Guanine Nucleotide Exchange Factor by Gerondopoulos, Andreas, Langemeyer, Lars, Liang, Jin-Rui, Linford, Andrea, Barr, Francis A.

“…Hermansky-Pudlak syndrome (HPS) is a human disease characterized by partial loss of pigmentation and impaired blood clotting [1–3]. These symptoms are caused…”
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The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes by Cabrera, Margarita, Nordmann, Mirjana, Perz, Angela, Schmedt, David, Gerondopoulos, Andreas, Barr, Francis, Piehler, Jacob, Engelbrecht-Vandré, Siegfried, Ungermann, Christian

“…To function in fusion and signaling, Rab GTPases need to be converted into their active GTP form. We previously identified the conserved Mon1-Ccz1 complex as…”
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Homozygous Mutations in TBC1D23 Lead to a Non-degenerative Form of Pontocerebellar Hypoplasia by Marin-Valencia, Isaac, Gerondopoulos, Andreas, Zaki, Maha S., Ben-Omran, Tawfeg, Almureikhi, Mariam, Demir, Ercan, Guemez-Gamboa, Alicia, Gregor, Anne, Issa, Mahmoud Y., Appelhof, Bart, Roosing, Susanne, Musaev, Damir, Rosti, Basak, Wirth, Sara, Stanley, Valentina, Baas, Frank, Barr, Francis A., Gleeson, Joseph G.

“…Pontocerebellar hypoplasia (PCH) represents a group of recessive developmental disorders characterized by impaired growth of the pons and cerebellum, which…”
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Murine norovirus-1 cell entry is mediated through a non-clathrin-, non-caveolae-, dynamin- and cholesterol-dependent pathway by Gerondopoulos, Andreas, Jackson, Terry, Monaghan, Paul, Doyle, Nicole, Roberts, Lisa O

“…For many viruses, endocytosis and exposure to the low pH within acidic endosomes is essential for infection. It has previously been reported that feline…”
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Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II by Levine, Timothy P., Daniels, Rachel D., Wong, Louise H., Gatta, Alberto T., Gerondopoulos, Andreas, Barr, Francis A.

“…Guanine nucleotide exchange factors (GEFs) control the site and extent of GTPase activity. Longin domains (LDs) are found in many Rab-GEFs, including DENNs,…”
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The Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin fold-Rab interface and association with PI-3-P-positive membranes by Cabrera, Margarita, Nordmann, Mirjana, Perz, Angela, Schmedt, David, Gerondopoulos, Andreas, Barr, Francis, Piehler, Jacob, Engelbrecht-Vandré, Siegfried, Ungermann, Christian

“…For their function in fusion and signaling, Rab GTPases need to be converted into their active GTP form. We previously identified the conserved Mon1-Ccz1…”
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Calicivirus translation initiation requires an interaction between VPg and eIF 4 E by Goodfellow, Ian, Chaudhry, Yasmin, Gioldasi, Ioanna, Gerondopoulos, Andreas, Natoni, Alessandro, Labrie, Louisette, Laliberté, Jean-François, Roberts, Lisa

“…Unlike other positive-stranded RNA viruses that use either a 5'-cap structure or an internal ribosome entry site to direct translation of their messenger RNA,…”
Get full text