Search Results - "Gerndt, Susanne"

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function by Gerndt, Susanne, Chen, Cheng-Chang, Chao, Yu-Kai, Yuan, Yu, Burgstaller, Sandra, Scotto Rosato, Anna, Krogsaeter, Einar, Urban, Nicole, Jacob, Katharina, Nguyen, Ong Nam Phuong, Miller, Meghan T, Keller, Marco, Vollmar, Angelika M, Gudermann, Thomas, Zierler, Susanna, Schredelseker, Johann, Schaefer, Michael, Biel, Martin, Malli, Roland, Wahl-Schott, Christian, Bracher, Franz, Patel, Sandip, Grimm, Christian

“…Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2,…”
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Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors by Rühl, Philipp, Rosato, Anna Scotto, Urban, Nicole, Gerndt, Susanne, Tang, Rachel, Abrahamian, Carla, Leser, Charlotte, Sheng, Jiansong, Jha, Archana, Vollmer, Günter, Schaefer, Michael, Bracher, Franz, Grimm, Christian

“…The cation channel TRPML1 is an important regulator of lysosomal function and autophagy. Loss of TRPML1 is associated with neurodegeneration and lysosomal…”
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Discovery of lipophilic two‐pore channel agonists by Gerndt, Susanne, Krogsaeter, Einar, Patel, Sandip, Bracher, Franz, Grimm, Christian

“…Two‐pore channels (TPCs) have been a hot topic in recent literature. Their involvement in various diseases such as viral infections and cancer is of great…”
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Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3 by Leser, Charlotte, Keller, Marco, Gerndt, Susanne, Urban, Nicole, Chen, Cheng-Chang, Schaefer, Michael, Grimm, Christian, Bracher, Franz

“…The members of the TRPML subfamily of non-selective cation channels (TRPML1-3) are involved in the regulation of important lysosomal and endosomal functions,…”
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The lysosomotrope GPN mobilises Ca2+ from acidic organelles by Yuan, Yu, Kilpatrick, Bethan S., Gerndt, Susanne, Bracher, Franz, Grimm, Christian, Schapira, Anthony H., Patel, Sandip

“…ABSTRACT Lysosomes are acidic Ca2+ stores often mobilised in conjunction with endoplasmic reticulum (ER) Ca2+ stores. Glycyl-L-phenylalanine 2-naphthylamide…”
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Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth by Müller, Martin, Gerndt, Susanne, Chao, Yu-Kai, Zisis, Themistoklis, Nguyen, Ong Nam Phuong, Gerwien, Aaron, Urban, Nicole, Müller, Christoph, Gegenfurtner, Florian A, Geisslinger, Franz, Ortler, Carina, Chen, Cheng-Chang, Zahler, Stefan, Biel, Martin, Schaefer, Michael, Grimm, Christian, Bracher, Franz, Vollmar, Angelika M, Bartel, Karin

“…The role of two-pore channel 2 (TPC2), one of the few cation channels localized on endolysosomal membranes, in cancer remains poorly understood. Here, we…”
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Racemic total synthesis and evaluation of the biological activities of the isoquinoline–benzylisoquinoline alkaloid muraricine by Schütz, Ramona, Müller, Martin, Gerndt, Susanne, Bartel, Karin, Bracher, Franz

“…The first racemic total synthesis of the isoquinoline–benzylisoquinoline alkaloid muraricine is reported herein. Pharmacological characterization identified…”
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Blocking Lysosomal Two-Pore Channel 2 Function Inhibits Proliferation of Multidrug Resistant Leukemia Cells and Sensitizes Them to Vincristine Treatment by Müller, Martin, Geisslinger, Franz, Gerndt, Susanne, Schütz, Ramona, Chao, Yu-Kai, Bracher, Franz, Grimm, Christian, Vollmar, Angelika, Bartel, Karin

“…Introduction Two-pore channel 2 (TPC2) represents an exceptional ion channel due to its localization on lysosomes1. TPC2 is overexpressed in several cancer…”
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An endo-lysosomal Ca2+ store in cardiomyocytes controlled by OCaR proteins determines fatal tachyarrhythmias by Berlin, Michael, Londoño, Juan Eduardo Camacho, Ottenheijm, Roger, Kraft, Axel, Bacmeister, Lucas, Tsvilovskyy, Volodymyr, Meyer, Sören, Hennis, Konstantin, Gerndt, Susanne, Offen, Kira, Leuschner, Florian, Bracher, Franz, Fenske, Stefanie, Biel, Martin, Hansen, Arne, Grimm, Christian, Wahl-Schott, Christian, Freichel, Marc

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Reversal of Chemoresistance in Leukemia Cells Using Synthetic Bisbenzylisoquinoline Derivatives by Müller, Martin, Gerndt, Susanne, Arner, Anja, Chao, Yu-Kai, Schömig, Linus, Atzberger, Carina, Biel, Martin, Bracher, Franz, Vollmar, Angelika, Binder, Vera, Keller, Marco, Grimm, Christian, Bartel, Karin

“…Introduction Chemoresistance represents a major problem for the treatment of leukemia patients, which frequently manifests in the multidrug resistance (MDR)…”
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The lysosomotrope GPN mobilises Ca 2+ from acidic organelles by Yuan, Yu, Kilpatrick, Bethan S, Gerndt, Susanne, Bracher, Franz, Grimm, Christian, Schapira, Anthony H, Patel, Sandip

“…Lysosomes are acidic Ca stores often mobilised in conjunction with endoplasmic reticulum (ER) Ca stores. Glycyl-L-phenylalanine 2-naphthylamide (GPN) is a…”
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