Search Results - "Germolec, D.R."

Contact sensitizing potential of pyrogallol and 5-amino- o -cresol in female BALB/c mice by Guo, T.L, Germolec, D.R, Zhang, Ling X, Auttachoat, W, Smith, M.J, White, K.L

“…Abstract Hair dye components such as pyrogallol and cresol have been shown previously to promote allergic reactions such as rashes, dermal inflammation,…”
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Immunotoxicology testing within the National Toxicology Program (NTP): reflections on the past, present and future by Germolec, D.R.

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Genistein Modulates Splenic Natural Killer Cell Activity, Antibody-Forming Cell Response, and Phenotypic Marker Expression in F0 and F1 Generations of Sprague-Dawley Rats by Guo, T.L, White, K.L, Brown, R.D, Delclos, K.B, Newbold, R.R, Weis, C, Germolec, D.R, McCay, J.A

“…The potential effects of the phytoestrogen genistein (GEN) on the immune system were evaluated in both F0 (dams) and F1 generations of Sprague-Dawley rats…”
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Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: Evidence of thymic regulation by Guo, T.L, Chi, R.P, Zhang, X.L, Musgrove, D.L, Weis, C, Germolec, D.R, White, K.L. Jr

“…To further determine whether genistein (GEN) modulation of the immune responses was related to its endocrine-disrupting properties and time of exposure,…”
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Genistein Protects Female Nonobese Diabetic Mice from Developing Type 1 Diabetes When Fed a Soy- and Alfalfa-free Diet by Guo, Tai L., Germolec, Dori R., Zheng, Jian Feng, Kooistra, Linda, Auttachoat, Wimolnut, Smith, Matthew J., White, Kimber L., Elmore, Susan A.

“…The objective of this study was to determine the effects of the phytoestrogen genistein (GEN) on the time of onset and/or the incidence of type 1 diabetes…”
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Subchronic exposure to fungal spores promotes allergic pulmonary inflammation by Germolec, D.R., Nayak, A.P., Green, B.J., Lemons, A.R., Croston, T.L., Goldsmith, W.T., Beezhold, D.H.

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NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory Response by Kim, J. M., Kosak, J. P., Kim, J. K., Kissling, Grace E., Germolec, D. R., Zeldin, D. C., Bradbury, J. A., Baek, Seung Joon, Eling, T. E.

“…NAG-1/GDF15 is a TGF-β superfamily member with poorly characterized biological activity proposed to inhibit inflammatory cytokine production. Transgenic mice…”
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Sensitivity and predictivity in immunotoxicity testing: immune endpoints and disease resistance by Germolec, D.R.

“…In spite of extensive laboratory data on the effects of chemicals and drugs on immunologic parameters in laboratory animals, and a well established correlation…”
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Oral exposure to atrazine modulates cell-mediated immune function and decreases host resistance to the B16F10 tumor model in female B6C3F1 mice by Karrow, N.A., McCay, J.A., Brown, R.D., Musgrove, D.L., Guo, T.L., Germolec, D.R., White, K.L.

“…Atrazine (ATZ) is used throughout North America to control annual broadleaf weeds and grasses in various crops including; corn, sorghum, and sugar cane…”
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Modulation of immune response following dietary genistein exposure in F 0 and F 1 generations of C57BL/6 mice: Evidence of thymic regulation by Guo, T.L., Chi, R.P., Zhang, X.L., Musgrove, D.L., Weis, C., Germolec, D.R., White, K.L.

“…To further determine whether genistein (GEN) modulation of the immune responses was related to its endocrine-disrupting properties and time of exposure,…”
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Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F 1 generations of Sprague–Dawley rats following developmental and adult exposures by Guo, T.L., Germolec, D.R., Musgrove, D.L., Delclos, K.B., Newbold, R.R., Weis, C., White, K.L.

“…The myelotoxicity of five endocrine active chemicals was evaluated in F 1 generation of Sprague–Dawley rats following developmental and adult exposures at…”
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Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F 0 and F 1 generations of Sprague Dawley rats by White, K.L., Germolec, D.R., Booker, C.D., Hernendez, D.M., McCay, J.A., Delclos, K.B., Newbold, R.R., Weis, C., Guo, T.L.

“…Methoxychlor, a chlorinated hydrocarbon pesticide, is a persistent environmental contaminant that has been identified in human reproductive tissues…”
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Myelotoxicity in genistein-, nonylphenol-, methoxychlor-, vinclozolin- or ethinyl estradiol-exposed F1 generations of Sprague-Dawley rats following developmental and adult exposures by GUO, T. L, GERMOLEC, D. R, MUSGROVE, D. L, DELCLOS, K. B, NEWBOLD, R. R, WEIS, C, WHITE, K. L

“…The myelotoxicity of five endocrine active chemicals was evaluated in F1 generation of Sprague-Dawley rats following developmental and adult exposures at three…”
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Nonylphenol alters the activity of splenic NK cells and the numbers of leukocyte subpopulations in Sprague–Dawley rats: a two-generation feeding study by Karrow, N.A, Guo, T.L, Delclos, K.B, Newbold, R.R, Weis, C, Germolec, D.R, White, K.L, McCay, J.Ann

“…Nonylphenol (NP) has been identified at low levels in surface waters throughout North America. This industrial chemical is primarily used for the production of…”
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Dietary methoxychlor exposure modulates splenic natural killer cell activity, antibody-forming cell response and phenotypic marker expression in F0 and F1 generations of Sprague Dawley rats by WHITE, K. L, GERMOLEC, D. R, BOOKER, C. D, HERNENDEZ, D. M, MCCAY, J. A, DELCLOS, K. B, NEWBOLD, R. R, WEIS, C, GUO, T. L

“…Methoxychlor, a chlorinated hydrocarbon pesticide, is a persistent environmental contaminant that has been identified in human reproductive tissues…”
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Antioxidants attenuate anthralin induced skin inflammation in Balb/C mice:Role of specific proinflammatory cytokines by Lange, R.W., Germolec, D.R., Foley, J.F., Luster, M.I.

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Thalidomide modulation of the immune response in female B6C3F1 mice: a host resistance study by Karrow, N.A., Guo, T.L., Zhang, L.X., McCay, J.A., Musgrove, D.L., Peachee, V.L., Germolec, D.R., White, K.L.

“…Previously, we have reported that thalidomide (Thd) treatment can modulate the immune responses in female B6C3F1 mice. The present study was designed to…”
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Thalidomide Stimulates Splenic IgM Antibody Response and Cytotoxic T Lymphocyte Activity and Alters Leukocyte Subpopulation Numbers in Female B6C3F1 Mice by Karrow, N.A., McCay, J.A., Brown, R.D., Musgrove, D.L., Pettit, D.A., Munson, A.E., Germolec, D.R., White, K.L.

“…Thalidomide has been shown to have antiinflammatory and, more recently, immunomodulating properties, which are beneficial for the treatment of an…”
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Carbon tetrachloride is immunosuppressive and decreases host resistance to Listeria monocytogenes and Streptococcus pneumoniae in female B6C3F1 mice by Guo, T.L., McCay, J.A., Brown, R.D., Musgrove, D.L., Germolec, D.R., Butterworth, L., Munson, A.E., White, K.L.

“…Carbon tetrachloride (CCl 4) is an environmental contaminant that has been detected in ambient air, seawater, surface-water and snow. The immunotoxic potential…”
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Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation by Luster, M.I, Germolec, D.R, Clark, G, Wiegand, G, Rosenthal, G.J

“…The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the corticosteroid dexamethasone have potent effects on lymphocyte function,…”
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