Search Results - "Germano, Juliana"
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At the heart of mitochondrial quality control: many roads to the top
Published in Cellular and molecular life sciences : CMLS (01-04-2021)“…Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of…”
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Ultraviolet A light effectively reduces bacteria and viruses including coronavirus
Published in PloS one (16-07-2020)“…Antimicrobial-resistant and novel pathogens continue to emerge, outpacing efforts to contain and treat them. Therefore, there is a crucial need for safe and…”
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Attenuation of Adverse Postinfarction Left Ventricular Remodeling with Empagliflozin Enhances Mitochondria-Linked Cellular Energetics and Mitochondrial Biogenesis
Published in International journal of molecular sciences (31-12-2021)“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors such as empagliflozin are known to reduce the risk of hospitalizations related to heart failure irrespective…”
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Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNA
Published in Virology (New York, N.Y.) (01-03-2019)“…Coxsackievirus B is a significant human pathogen and is a leading cause of myocarditis. We and others have observed that certain enteroviruses including…”
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Intermittent Use of a Short-Course Glucagon-like Peptide-1 Receptor Agonist Therapy Limits Adverse Cardiac Remodeling via Parkin-dependent Mitochondrial Turnover
Published in Scientific reports (19-05-2020)“…Given that adverse remodeling is the leading cause of heart failure and death in the USA, there is an urgent unmet need to develop new methods in dealing with…”
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Low dose rifaximin combined with N-acetylcysteine is superior to rifaximin alone in a rat model of IBS-D: a randomized trial
Published in Scientific reports (05-08-2024)“…Rifaximin is FDA-approved for treatment of irritable bowel syndrome with diarrhea (IBS-D), but poor solubility may limit its efficacy against microbes in the…”
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Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis
Published in Biochimica et biophysica acta. Molecular basis of disease (01-11-2019)“…During pancreatitis, autophagy is activated, but lysosomal degradation of dysfunctional organelles including mitochondria is impaired, resulting in acinar cell…”
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Analysis of Circulating miR‐1, miR‐23a, and miR‐26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery
Published in Annals of human genetics (01-05-2017)“…Summary Atrial fibrillation (AF) is the most common arrhythmia after cardiac surgery. From a pathophysiological point of view, a myriad of factors such as…”
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Proteomics of Mouse Heart Ventricles Reveals Mitochondria and Metabolism as Major Targets of a Post-Infarction Short-Acting GLP1Ra-Therapy
Published in International journal of molecular sciences (13-08-2021)“…Cardiovascular disease is the main cause of death worldwide, making it crucial to search for new therapies to mitigate major adverse cardiac events (MACEs)…”
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Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
Published in PloS one (20-09-2019)“…Abdominal aortic aneurysm (AAA) is a pathological enlargement of infrarenal aorta close to the aortic bifurcation, and it is an important cause of mortality in…”
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Cytolethal distending toxin B inoculation leads to distinct gut microtypes and IBS-D-like microRNA-mediated gene expression changes in a rodent model
Published in Gut microbes (2024)“…Diarrhea-predominant irritable bowel syndrome (IBS-D), associated with increased intestinal permeability, inflammation, and small intestinal bacterial…”
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Antiviral Effects of Menthol on Coxsackievirus B
Published in Viruses (28-03-2020)“…Coxsackievirus B (CVB) is a common human enterovirus that causes systemic infection but specifically replicates to high titers in the pancreas. It was reported…”
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Increased β-hydroxybutyrate (BHBA) concentration affect follicular growth in cattle
Published in Animal reproduction science (01-08-2022)“…Metabolic stress conditions caused by negative energy balance (NEB) have been associated with reduced fertility in cows. β-hydroxybutyrate (BHBA) is the main…”
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Prostaglandin F2α regulation and function during ovulation and luteinization in cows
Published in Theriogenology (01-09-2021)“…Although prostaglandins are important in the ovulation process, a precise role for prostaglandin F2α (PGF) has not been elucidated. This study aimed to…”
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High concentrations of β‐hydroxybutyrate alter the kinetics of bovine spermatozoa
Published in Andrologia (01-09-2021)“…Postpartum cows, mainly with metabolic diseases, such as ketosis, usually experience an increased number of services per conception. During ketosis, high…”
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Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis
Published in Frontiers in immunology (30-05-2023)“…Osteopontin (OPN; also known as SPP1), an immunomodulatory cytokine highly expressed in bone marrow-derived macrophages (BMMΦ), is known to regulate diverse…”
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Perfil sociodemográfico de portadores de Diabetes Mellitus e hipertensão arterial de uma comunidade religiosa
Published in Revista de Saúde Pública do Paraná (Online) (29-11-2021)“…Doenças crônicas não transmissíveis são um importante agravo da saúde da população mundial. Além de serem onerosas para o sistema público de saúde e um desafio…”
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