Search Results - "Germann, Allison L."

Multiple functional neurosteroid binding sites on GABAA receptors by Chen, Zi-Wei, Bracamontes, John R, Budelier, Melissa M, Germann, Allison L, Shin, Daniel J, Kathiresan, Krishnan, Qian, Ming-Xing, Manion, Brad, Cheng, Wayland W L, Reichert, David E, Akk, Gustav, Covey, Douglas F, Evers, Alex S

“…Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for…”
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Modulation of the mammalian GABAA receptor by type I and type II positive allosteric modulators of the α7 nicotinic acetylcholine receptor by Arias, Hugo R., Germann, Allison L., Pierce, Spencer R., Sakamoto, Seiji, Ortells, Marcelo O., Hamachi, Itaru, Akk, Gustav

“…Background and Purpose Positive allosteric modulators of the α7 nicotinic acetylcholine (nACh) receptor (α7‐PAMs) possess promnesic and procognitive properties…”
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Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABAA Receptor: Relating Occupancy to State Functions by Akk, Gustav, Germann, Allison L, Sugasawa, Yusuke, Pierce, Spencer R, Evers, Alex S, Steinbach, Joe Henry

“…Muscimol is a psychoactive isoxazole derived from the mushroom Amanita muscaria and a potent orthosteric agonist of the GABAA receptor. The binding of…”
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Site-specific effects of neurosteroids on GABAA receptor activation and desensitization by Sugasawa, Yusuke, Cheng, Wayland WL, Bracamontes, John R, Chen, Zi-Wei, Wang, Lei, Germann, Allison L, Pierce, Spencer R, Senneff, Thomas C, Krishnan, Kathiresan, Reichert, David E, Covey, Douglas F, Akk, Gustav, Evers, Alex S

“…This study examines how site-specific binding to three identified neurosteroid-binding sites in the α 1 β 3 GABA A receptor (GABA A R) contributes to…”
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Application of the Co-Agonist Concerted Transition Model to Analysis of GABAA Receptor Properties by Germann, Allison L, Steinbach, Joe Henry, Akk, Gustav

“…The co-agonist concerted transition model is a simple and practical solution to analyze various aspects of GABAA receptor function. Several model-based…”
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Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol by Eaton, Megan M, Germann, Allison L, Arora, Ruby, Cao, Lily Q, Gao, Xiaoyi, Shin, Daniel J, Wu, Albert, Chiara, David C, Cohen, Jonathan B, Steinbach, Joe Henry, Evers, Alex S, Akk, Gustav

“…Background: Propofol is a sedative agent that at clinical concentrations acts by allosterically activating or potentiating the ?-aminobutyric acid type A…”
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Activation of the α1β2γ2L GABAA Receptor by Physiological Agonists by Pierce, Spencer R., Germann, Allison L., Akk, Gustav

“…The Cl− permeable GABAA receptor is a major contributor to cellular inhibition in the brain. The receptor is normally activated by synaptically-released or…”
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Activation of the Rat α1β2ε GABAA Receptor by Orthosteric and Allosteric Agonists by Germann, Allison L., Burbridge, Ariel B., Pierce, Spencer R., Akk, Gustav

“…GABAA receptors are a major contributor to fast inhibitory neurotransmission in the brain. The receptors are activated upon binding the transmitter GABA or…”
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Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABAA Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor by Pierce, Spencer R., Germann, Allison L., Xu, Sophia Q., Menon, Saumith L., Ortells, Marcelo O., Arias, Hugo R., Akk, Gustav

“…The positive allosteric modulators (PAMs) of the α7 nicotinic receptor N-(5-Cl-2-hydroxyphenyl)-N′-[2-Cl-5-(trifluoromethyl)phenyl]-urea (NS-1738) and…”
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The Mechanism of Enantioselective Neurosteroid Actions on GABAA Receptors by Tateiwa, Hiroki, Chintala, Satyanarayana M., Chen, Ziwei, Wang, Lei, Amtashar, Fatima, Bracamontes, John, Germann, Allison L., Pierce, Spencer R., Covey, Douglas F., Akk, Gustav, Evers, Alex S.

“…The neurosteroid allopregnanolone (ALLO) and pregnanolone (PREG), are equally effective positive allosteric modulators (PAMs) of GABAA receptors…”
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Steady‐state activation and modulation of the synaptic‐type α1β2γ2L GABAA receptor by combinations of physiological and clinical ligands by Germann, Allison L., Pierce, Spencer R., Senneff, Thomas C., Burbridge, Ariel B., Steinbach, Joe Henry, Akk, Gustav

“…The synaptic α1β2γ2 GABAA receptor is activated phasically by presynaptically released GABA. The receptor is considered to be inactive between synaptic events…”
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Potentiation of the GABA A R reveals variable energetic contributions by etiocholanolone and propofol by Pierce, Spencer R, Xu, Sophia Q, Germann, Allison L, Steinbach, Joe Henry, Akk, Gustav

“…The properties of a potentiator are typically evaluated by measuring its ability to enhance the magnitude of the control response. Analysis of the ability of…”
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The Actions of Drug Combinations on the GABA A Receptor Manifest as Curvilinear Isoboles of Additivity by Shin, Daniel J, Germann, Allison L, Steinbach, Joe Henry, Akk, Gustav

“…Drug interactions are often analyzed in terms of isobolograms. In the isobologram, the line connecting the axial points corresponding to the concentrations of…”
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The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α 1 β 3 γ 2L GABA A Receptor by Stabilizing a Novel Nonconducting State by Pierce, Spencer R, Germann, Allison L, Steinbach, Joe Henry, Akk, Gustav

“…The GABA receptor is inhibited by the endogenous sulfated steroids pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS). It has been proposed…”
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The Sulfated Steroids Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate Inhibit the α1β3γ2L GABAA Receptor by Stabilizing a Novel Nonconducting State by Pierce, Spencer R., Germann, Allison L., Steinbach, Joe Henry, Akk, Gustav

“…The GABA A receptor is inhibited by the endogenous sulfated steroids pregnenolone sulfate (PS) and dehydroepiandrosterone sulfate (DHEAS). It has been proposed…”
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Analysis of GABA A Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites by Shin, Daniel J, Germann, Allison L, Covey, Douglas F, Steinbach, Joe Henry, Akk, Gustav

“…Under both physiologic and clinical conditions GABA receptors are exposed to multiple agonists, including the transmitter GABA, endogenous or exogenous…”
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Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor by Arias, Hugo R, Pierce, Spencer R, Germann, Allison L, Xu, Sophia Q, Ortells, Marcelo O, Sakamoto, Seiji, Manetti, Dina, Romanelli, Maria Novella, Hamachi, Itaru, Akk, Gustav

“…Acrylamide-derived compounds have been previously shown to act as modulators of members of the Cys-loop transmitter-gated ion channel family, including the…”
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Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABA A Receptors by Shin, Daniel J, Germann, Allison L, Johnson, Alexander D, Forman, Stuart A, Steinbach, Joe Henry, Akk, Gustav

“…GABA receptors can be directly activated and potentiated by the intravenous anesthetic propofol. Previous photolabeling, modeling, and functional data have…”
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Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA A Receptor: Relating Occupancy to State Functions by Akk, Gustav, Germann, Allison L, Sugasawa, Yusuke, Pierce, Spencer R, Evers, Alex S, Steinbach, Joe Henry

“…Muscimol is a psychoactive isoxazole derived from the mushroom and a potent orthosteric agonist of the GABA receptor. The binding of [ H]muscimol has been used…”
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Steady-state activation of the high-affinity isoform of the α4β2δ GABAA receptor by Pierce, Spencer R., Senneff, Thomas C., Germann, Allison L., Akk, Gustav

“…Activation of GABA A receptors consisting of α4, β2 (or β3), and δ subunits is a major contributor to tonic inhibition in several brain regions. The goal of…”
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