Search Results - "German, Polina"

Safety, Tolerability, and Pharmacokinetics of Remdesivir, An Antiviral for Treatment of COVID‐19, in Healthy Subjects by Humeniuk, Rita, Mathias, Anita, Cao, Huyen, Osinusi, Anu, Shen, Gong, Chng, Estelle, Ling, John, Vu, Amanda, German, Polina

“…Remdesivir (RDV), a single diastereomeric monophosphoramidate prodrug that inhibits viral RNA polymerases, has potent in vitro antiviral activity against…”
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Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor by Humeniuk, Rita, Mathias, Anita, Kirby, Brian J., Lutz, Justin D., Cao, Huyen, Osinusi, Anu, Babusis, Darius, Porter, Danielle, Wei, Xuelian, Ling, John, Reddy, Y. Sunila, German, Polina

“…Remdesivir (RDV, Veklury ® ) is a once-daily, nucleoside ribonucleic acid polymerase inhibitor of severe acute respiratory syndrome coronavirus 2 replication…”
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Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1 by Naggie, Susanna, Cooper, Curtis, Saag, Michael, Workowski, Kimberly, Ruane, Peter, Towner, William J, Marks, Kristen, Luetkemeyer, Anne, Baden, Rachel P, Sax, Paul E, Gane, Edward, Santana-Bagur, Jorge, Stamm, Luisa M, Yang, Jenny C, German, Polina, Dvory-Sobol, Hadas, Ni, Liyun, Pang, Phillip S, McHutchison, John G, Stedman, Catherine A.M, Morales-Ramirez, Javier O, Bräu, Norbert, Jayaweera, Dushyantha, Colson, Amy E, Tebas, Pablo, Wong, David K, Dieterich, Douglas, Sulkowski, Mark

“…Among patients coinfected with HIV-1 and HCV genotype 1 or 4 who were receiving effective antiretroviral therapy, treatment with 12 weeks of ledipasvir and…”
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Clinical Pharmacokinetics and Pharmacodynamics of Ledipasvir/Sofosbuvir, a Fixed-Dose Combination Tablet for the Treatment of Hepatitis C by German, Polina, Mathias, Anita, Brainard, Diana, Kearney, Brian P.

“…Ledipasvir/sofosbuvir (Harvoni ® ), a fixed-dose combination tablet of an NS5A inhibitor ledipasvir and an NS5B polymerase inhibitor sofosbuvir, is approved in…”
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Clinical Pharmacology of Artemisinin-Based Combination Therapies by Aweeka, Francesca T., German, Polina I.

“…Malaria, a disease transmitted by the female Anopheles mosquito, has had devastating effects on human populations for more than 4000 years. Treatment of the…”
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Clinical Pharmacokinetic and Pharmacodynamic Profile of the HIV Integrase Inhibitor Elvitegravir by Ramanathan, Srinivasan, Mathias, Anita A., German, Polina, Kearney, Brian P.

“…Elvitegravir is a potent, boosted, once-daily, HIV integrase inhibitor with antiviral activity against wild-type and drug-resistant strains of HIV. Because…”
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A Phase 2, Randomized, Double-blind, Placebo-Controlled Trial of Presatovir for the Treatment of Respiratory Syncytial Virus Upper Respiratory Tract Infection in Hematopoietic-Cell Transplant Recipients by Chemaly, Roy F, Dadwal, Sanjeet S, Bergeron, Anne, Ljungman, Per, Kim, Yae-Jean, Cheng, Guang-Shing, Pipavath, Sudhakar N, Limaye, Ajit P, Blanchard, Elodie, Winston, Drew J, Stiff, Patrick J, Zuckerman, Tsila, Lachance, Silvy, Rahav, Galia, Small, Catherine B, Mullane, Kathleen M, Patron, Roberto L, Lee, Dong-Gun, Hirsch, Hans H, Waghmare, Alpana, McKevitt, Matt, Jordan, Robert, Guo, Ying, German, Polina, Porter, Danielle P, Gossage, David L, Watkins, Timothy R, Marty, Francisco M, Chien, Jason W, Boeckh, Michael

“…Abstract Background Hematopoietic-cell transplant (HCT) recipients are at risk for severe respiratory syncytial virus (RSV) infection. We evaluated the RSV…”
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Drug–Drug Interaction Profile of the Fixed-Dose Combination Tablet Regimen Ledipasvir/Sofosbuvir by German, Polina, Mathias, Anita, Brainard, Diana M., Kearney, Brian P.

“…Ledipasvir/sofosbuvir (Harvoni ® ), a fixed-dose combination tablet of an NS5A inhibitor ledipasvir and an NS5B polymerase inhibitor sofosbuvir, is approved…”
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Use of Multiple Probes to Assess Transporter- and Cytochrome P450-Mediated Drug–Drug Interaction Potential of the Pangenotypic HCV NS5A Inhibitor Velpatasvir by Mogalian, Erik, German, Polina, Kearney, Brian P., Yang, Cheng Yong, Brainard, Diana, McNally, John, Moorehead, Lisa, Mathias, Anita

“…Background and Objectives Velpatasvir (VEL; GS-5816) is a potent, pangenotypic hepatitis C virus (HCV), non-structural protein 5A inhibitor in clinical…”
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Pharmacokinetics, disposition, and biotransformation of the cardiac myosin inhibitor aficamten in humans by Xu, Donghong, Divanji, Punag, Griffith, Adrienne, Sukhun, Rajaa, Cheplo, Kathleen, Li, Jianlin, German, Polina

“…Aficamten, a cardiac myosin inhibitor, is being developed for the treatment of patients with symptomatic hypertrophic cardiomyopathy (HCM). The purpose of this…”
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Pharmacokinetics of Artemether-Lumefantrine and Artesunate-Amodiaquine in Children in Kampala, Uganda by MWESIGWA, Julia, PARIKH, Sunil, ROSENTHAL, Philip J, KAMYA, Moses R, AWEEKA, Francesca, MCGEE, Bryan, GERMAN, Polina, DRYSDALE, Troy, KALYANGO, Joan N, CLARK, Tamara D, DORSEY, Grant, LINDEGARDH, Niklas, ANNERBERG, Anna

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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P-6 SOFOSBUVIR CONTAINING REGIMENS ARE SAFE AND EFFECTIVE IN ADOLESCENTS WITH CHRONIC HEPATITIS C INFECTION by Wirth, Stefan, Gonzalez-Peralta, Regino, Rosenthal, Philip, Hardikar, Winita, Wen, Jessica, Jonas, Maureen M., Mittal, Naveen, Whitworth, Mary, Arnon, Ronen, Lin, Chuan-Hao, Lobzin, Yury, Romero, Rene, Chulanov, Vladimir, Subbarao, Girish, Teckman, Jeffrey, Morozov, Vyacheslav, Bassetti, Eric, Kersey, Kathryn, Massetto, Benedetta, Zhu, Yanni, German, Polina, Brainard, Diana M., Bansal, Sanjay, Murray, Karen F., Schwarz, Kathleen, Balistreri, William

“…HCV-specific DAAs have transformed treatment of chronic HCV, but few studies have evaluated these therapies in children. Patients aged 12–17 years old with…”
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Hepatotoxicity Due to a Drug Interaction between Amodiaquine plus Artesunate and Efavirenz by German, Polina, Greenhouse, Bryan, Coates, Carrie, Dorsey, Grant, Rosenthal, Philip J., Charlebois, Edwin, Lindegardh, Niklas, Havlir, Diane, Aweeka, Francesca T.

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Physiologically‐Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID‐19 by Lutz, Justin D., Mathias, Anita, German, Polina, Pikora, Cheryl, Reddy, Sunila, Kirby, Brian J.

“…Severe coronavirus disease 2019 (COVID‐19) disease, including multisystem inflammatory syndrome, has been reported in children. This report summarizes…”
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Validation of LC-MS/MS methods for determination of remdesivir and its metabolites GS-441524 and GS-704277 in acidified human plasma and their application in COVID-19 related clinical studies by Xiao, Deqing, John Ling, Kah Hiing, Tarnowski, Thomas, Humeniuk, Rita, German, Polina, Mathias, Anita, Chu, Jasper, Chen, Yuan-Shek, van Ingen, Eric

“…Remdesivir (RDV) is a phosphoramidate prodrug designed to have activity against a broad spectrum of viruses. Following IV administration, RDV is rapidly…”
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The drug-drug interaction potential of antiviral agents for the treatment of chronic hepatitis C infection by Garrison, Kimberly L, German, Polina, Mogalian, Erik, Mathias, Anita

“…Several safe and highly-effective directly-acting antiviral drugs for chronic hepatitis C virus (HCV) have been developed and greatly increase the number of…”
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The safety and effectiveness of ledipasvir−sofosbuvir in adolescents 12‐17 years old with hepatitis C virus genotype 1 infection by Balistreri, William F., Murray, Karen F., Rosenthal, Philip, Bansal, Sanjay, Lin, Chuan‐Hao, Kersey, Kathryn, Massetto, Benedetta, Zhu, Yanni, Kanwar, Bittoo, German, Polina, Svarovskaia, Evguenia, Brainard, Diana M., Wen, Jessica, Gonzalez‐Peralta, Regino P., Jonas, Maureen M., Schwarz, Kathleen

“…No all‐oral, direct‐acting antiviral regimens have been approved for children with chronic hepatitis C virus (HCV) infection. We conducted a phase 2,…”
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Effect of Cobicistat on Glomerular Filtration Rate in Subjects With Normal and Impaired Renal Function by German, Polina, Liu, Hui C, Szwarcberg, Javier, Hepner, Mischa, Andrews, Jessica, Kearney, Brian P, Mathias, Anita

“…OBJECTIVE:This study evaluated the effect of cobicistat (COBI) on glomerular filtration rate in subjects with normal renal function (RF) or with mild/moderate…”
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Vesatolimod, a Toll-like Receptor 7 Agonist, Induces Immune Activation in Virally Suppressed Adults Living With Human Immunodeficiency Virus–1 by Riddler, Sharon A, Para, Michael, Benson, Constance A, Mills, Anthony, Ramgopal, Moti, DeJesus, Edwin, Brinson, Cynthia, Cyktor, Joshua, Jacobs, Jana, Koontz, Dianna, Mellors, John W, Laird, Gregory M, Wrin, Terri, Patel, Heena, Guo, Susan, Wallin, Jeffrey, Boice, Jillian, Zhang, Liao, Humeniuk, Rita, Begley, Rebecca, German, Polina, Graham, Hiba, Geleziunas, Romas, Brainard, Diana M, SenGupta, Devi

“…Abstract Background Treatment with vesatolimod, an investigational, oral, toll-like receptor 7 (TLR7) agonist, leads to sustained viral remission in some…”
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Preclinical Pharmacokinetics and First-in-Human Pharmacokinetics, Safety, and Tolerability of Velpatasvir, a Pangenotypic Hepatitis C Virus NS5A Inhibitor, in Healthy Subjects by Mogalian, Erik, German, Polina, Kearney, Brian P, Yang, Cheng Yong, Brainard, Diana, Link, John, McNally, John, Han, LingLing, Ling, John, Mathias, Anita

“…Preclinical characterization of velpatasvir (VEL; GS-5816), an inhibitor of the hepatitis C virus (HCV) NS5A protein, demonstrated that it has favorable and…”
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