Search Results - "German, Nadezhda A"

Editorial: Novel therapeutic approaches to treat neuroinflammation in the central nervous system by German, Nadezhda A.

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Exploring diflunisal as a synergistic agent against Staphylococcus aureus biofilm formation by Salazar, Maria, Shahbazi Nia, Siavash, German, Nadezhda A, Awosile, Babafela, Sabiu, Saheed, Calle, Alexandra

“…is a bacterial pathogen of considerable significance in public health, capable of inducing a diverse range of infectious diseases. One of the most notorious…”
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Substituted Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor by Perrey, David A, German, Nadezhda A, Gilmour, Brian P, Li, Jun-Xu, Harris, Danni L, Thomas, Brian F, Zhang, Yanan

“…Increasing evidence implicates the orexin 1 (OX1) receptor in reward processes, suggesting OX1 antagonism could be therapeutic in drug addiction. In a program…”
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Chronic Administration of Cannabinoid Receptor 2 Agonist (JWH-133) Increases Ectopic Ovarian Tumor Growth and Endocannabinoids (Anandamide and 2-Arachidonoyl Glycerol) Levels in Immunocompromised SCID Female Mice by Blanton, Henry L, McHann, Melissa C, De Selle, Haley, Dancel, Canice Lei, Redondo, Jose-Luis, Molehin, Deborah, German, Nadezhda A, Trasti, Scott, Pruitt, Kevin, Castro-Piedras, Isabel, Guindon, Josée

“…Cannabinoid-based therapies are increasingly being used by cancer patients to treat chemotherapy-induced nausea and vomiting. Recently, cannabinoids have…”
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Mechanisms of angiogenesis in microbe-regulated inflammatory and neoplastic conditions by Sajib, Sanaullah, Zahra, Fatema Tuz, Lionakis, Michail S., German, Nadezhda A., Mikelis, Constantinos M.

“…Commensal microbiota inhabit all the mucosal surfaces of the human body. It plays significant roles during homeostatic conditions, and perturbations in numbers…”
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Effect of 1‑Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin‑1 Receptor by Perrey, David A, German, Nadezhda A, Decker, Ann M, Thorn, David, Li, Jun-Xu, Gilmour, Brian P, Thomas, Brian F, Harris, Danni L, Runyon, Scott P, Zhang, Yanan

“…Selective blockade of the orexin-1 receptor (OX1) has been suggested as a potential approach to drug addiction therapy because of its role in modulating the…”
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Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence by Hossain, Mohammad Anwar, Sattenapally, Narsimha, Parikh, Hardik I., Li, Wei, Rumbaugh, Kendra P., German, Nadezhda A.

“…Anti-virulence approaches in the treatment of Pseudomonas aeruginosa (PA)-induced infections have shown clinical potential in multiple in vitro and in vivo…”
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Design, synthesis and biological evaluations of a long-acting, hypoxia-activated prodrug of fasudil, a ROCK inhibitor, to reduce its systemic side-effects by Al-Hilal, Taslim A., Hossain, Mohammad Anwar, Alobaida, Ahmed, Alam, Farzana, Keshavarz, Ali, Nozik-Grayck, Eva, Stenmark, Kurt R., German, Nadezhda A., Ahsan, Fakhrul

“…ROCK, one of the downstream regulators of Rho, controls actomyosin cytoskeleton organization, stress fiber formation, smooth muscle contraction, and cell…”
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Bacterial Survival in Dictyostelium by Rønn, Regin, Hao, Xiuli, Lüthje, Freja, A German, Nadezhda, Li, Xuanji, Huang, Fuyi, Kisaka, Javan, Huffman, David, Alwathnani, Hend A, Zhu, Yong-Guan, Rensing, Christopher

“…We performed an assay to test the ability of different strains to survive inside amoebal cells after ingestion. In the assay we incubated bacteria together…”
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Endothelial-Specific Targeting of RhoA Signaling via CD31 Antibody-Conjugated Nanoparticles by Lahooti, Behnaz, Akwii, Racheal G, Patel, Dhavalkumar, ShahbaziNia, Siavash, Lamprou, Margarita, Madadi, Mahboubeh, Abbruscato, Thomas J, Astrinidis, Aristotelis, Bickel, Ulrich, Al-Ahmad, Abraham, German, Nadezhda A, Mattheolabakis, George, Mikelis, Constantinos M

“…Existing vascular endothelial growth factor-oriented antiangiogenic approaches are known for their high potency. However, significant side effects associated…”
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A role for copper in protozoan grazing – two billion years selecting for bacterial copper resistance by Hao, Xiuli, Lüthje, Freja, Rønn, Regin, German, Nadezhda A., Li, Xuanji, Huang, Fuyi, Kisaka, Javan, Huffman, David, Alwathnani, Hend A., Zhu, Yong‐Guan, Rensing, Christopher

“…Summary The Great Oxidation Event resulted in integration of soft metals in a wide range of biochemical processes including, in our opinion, killing of…”
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Studies on diketopiperazine and dipeptide analogs as opioid receptor ligands by Shahbazi Nia, Siavash, Hossain, Mohammad Anwar, Ji, Guangchen, Jonnalagadda, Sravan K., Obeng, Samuel, Rahman, Md Ashrafur, Sifat, Ali Ehsan, Nozohouri, Saeideh, Blackwell, Collin, Patel, Dhavalkumar, Thompson, Jon, Runyon, Scott, Hiranita, Takato, McCurdy, Christopher R., McMahon, Lance, Abbruscato, Thomas J., Trippier, Paul C., Neugebauer, Volker, German, Nadezhda A.

“…Using the structure of gliotoxin as a starting point, we have prepared two different chemotypes with selective affinity to the kappa opioid receptor (KOR)…”
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Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity by Ashraf-Uz-Zaman, Md, Sajib, Md Sanaullah, Cucullo, Luca, Mikelis, Constantinos M., German, Nadezhda A.

“…[Display omitted] •Anticancer doses of penfluridol inhibit a majority of G-protein coupled receptors.•Analysis of antipsychotic pharmacophore allowed to design…”
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Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer by Ashraf-Uz-Zaman, Md, Shahi, Sadisna, Akwii, Racheal, Sajib, Md Sanaullah, Farshbaf, Mohammad Jodeiri, Kallem, Raja Reddy, Putnam, William, Wang, Wei, Zhang, Ruiwen, Alvina, Karina, Trippier, Paul C., Mikelis, Constantinos M., German, Nadezhda A.

“…Triple-negative breast cancer (TNBC) is an aggressive type of cancer characterized by higher metastatic and reoccurrence rates, where approximately one-third…”
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Assessing the Current State of Lung Cancer Chemoprevention: A Comprehensive Overview by Ashraf-Uz-Zaman, Md, Bhalerao, Aditya, Mikelis, Constantinos M, Cucullo, Luca, German, Nadezhda A

“…Chemoprevention of lung cancer is thought to significantly reduce the risk of acquiring these conditions in the subpopulation of patients with underlying…”
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Mechanistic Aspects of Biphenyl Urea-Based Analogues in Triple-Negative Breast Cancer Cell Lines by Bandy, Rayna, Shahi, Sadisna, Quagraine, Naana, Shahbazi Nia, Siavash, Howlader, Md Sariful Islam, Srivenugopal, Kalkunte, Stephan, Clifford, Das, Hiranmoy, Mikelis, Constantinos M., German, Nadezhda A.

“…Triple-negative breast cancer (TNBC) poses significant challenges due to its aggressive nature and limited treatment options. In this study, we investigated…”
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Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis by Ashraf-Uz-Zaman, Md, Ji, Guangchen, Tidwell, Dalton, Yin, Linda, Thakolwiboon, Smathorn, Pan, Jie, Junell, Riley, Griffin, Zach, Shahi, Sadisna, Barthels, Derek, Sajib, Md Sanaullah, Trippier, Paul C, Mikelis, Constantinos M, Das, Hiranmoy, Avila, Mirla, Neugebauer, Volker, German, Nadezhda A

“…The dopaminergic system is involved in the regulation of immune responses in various homeostatic and disease conditions. For conditions such as Parkinson’s…”
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Characterization of a Nonselective Opioid Receptor Functional Antagonist: Implications for Development as a Novel Opioid Dependence Medication by Shahbazi Nia, Siavash, Ortiz, Yuma T., Zuarth Gonzalez, Julio D., Shamir, Leila, Frimpong-Manson, Kofi, Hossain, Mohammad Anwar, Shahi, Sadisna, Bandy, Rayna, Bhat, Anoushka, Patel, Dhavalkumar, Diab, Hanin, Thompson, Jonathan, McMahon, Lance R., Wilkerson, Jenny L., German, Nadezhda A.

“…Opioids represent the most extensive category of abused substances in the United States, and the number of fatalities caused by these drugs exceeds those…”
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Truncated Orexin Peptides: Structure–Activity Relationship Studies by German, Nadezhda A, Decker, Ann M, Gilmour, Brian P, Thomas, Brian F, Zhang, Yanan

“…Orexin receptors are involved in many processes including energy homeostasis, wake/sleep cycle, metabolism, and reward. Development of potent and selective…”
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Structure-activity relationship studies on the tetrahydroisoquinoline-based orexin 1 receptor antagonists: The 1-benzyl position by Zhang, Yanan, Perrey, David A, Harris, Danni L, German, Nadezhda A, Decker, Ann M, Gilmour, Brian P, Thomas, Brian F

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