Search Results - "Germaine, D"

Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH by Loomba, Rohit, Sanyal, Arun J., Kowdley, Kris V., Bhatt, Deepak L., Alkhouri, Naim, Frias, Juan P., Bedossa, Pierre, Harrison, Stephen A., Lazas, Donald, Barish, Robert, Gottwald, Mildred D., Feng, Shibao, Agollah, Germaine D., Hartsfield, Cynthia L., Mansbach, Hank, Margalit, Maya, Abdelmalek, Manal F.

“…In this phase 2b, placebo-controlled trial involving patients with nonalcoholic steatohepatitis, pegozafermin, a long-acting glycopegylated FGF21 analogue,…”
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Spatio-temporal changes of lymphatic contractility and drainage patterns following lymphadenectomy in mice by Kwon, Sunkuk, Agollah, Germaine D, Wu, Grace, Sevick-Muraca, Eva M

“…To investigate the redirection of lymphatic drainage post-lymphadenectomy using non-invasive near-infrared fluorescence (NIRF) imaging, and to subsequently…”
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The FGF21 analog pegozafermin in severe hypertriglyceridemia: a randomized phase 2 trial by Bhatt, Deepak L., Bays, Harold E., Miller, Michael, Cain, James E., Wasilewska, Katarzyna, Andrawis, Nabil S., Parli, Teresa, Feng, Shibao, Sterling, Lulu, Tseng, Leo, Hartsfield, Cynthia L., Agollah, Germaine D., Mansbach, Hank, Kastelein, John J. P.

“…Pegozafermin, a long-acting glycopegylated analog of human fibroblast growth factor 21, is in development for the treatment of severe hypertriglyceridemia…”
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Clinical trial: Effects of pegozafermin on the liver and on metabolic comorbidities in subjects with biopsy-confirmed nonalcoholic steatohepatitis by Alkhouri, Naim, Lazas, Donald, Loomba, Rohit, Frias, Juan P, Feng, Shibao, Tseng, Leo, Balic, Kemal, Agollah, Germaine D, Kwan, Tinna, Iyer, Janani S, Morrow, Linda, Mansbach, Hank, Margalit, Maya, Harrison, Stephen A

“…An approved therapy for nonalcoholic steatohepatitis (NASH) and fibrosis remains a major unmet medical need. To investigate the histological and metabolic…”
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Author Correction: The FGF21 analog pegozafermin in severe hypertriglyceridemia: a randomized phase 2 trial by Bhatt, Deepak L., Bays, Harold E., Miller, Michael, Cain, James E., Wasilewska, Katarzyna, Andrawis, Nabil S., Parli, Teresa, Feng, Shibao, Sterling, Lulu, Tseng, Leo, Hartsfield, Cynthia L., Agollah, Germaine D., Mansbach, Hank, Kastelein, John J. P.

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Dextran sulfate sodium-induced acute colitis impairs dermal lymphatic function in mice by Agollah, Germaine D, Wu, Grace, Peng, Ho-Lan, Kwon, Sunkuk

“…AIM: To investigate whether dermal lymphatic function and architecture are systemically altered in dextran sulfate sodium(DSS)-induced acute colitis.METHODS:…”
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Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction by Agollah, Germaine D, Gonzalez-Garay, Manuel L, Rasmussen, John C, Tan, I-Chih, Aldrich, Melissa B, Darne, Chinmay, Fife, Caroline E, Guilliod, Renie, Maus, Erik A, King, Philip D, Sevick-Muraca, Eva M

“…The lymphatic vasculature plays a critical role in a number of disease conditions of increasing prevalence, such as autoimmune disorders, obesity, blood…”
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Altered lymphatic function and architecture in salt-induced hypertension assessed by near-infrared fluorescence imaging by Kwon, Sunkuk, Agollah, Germaine D, Chan, Wenyaw, Sevick-Muraca, Eva M

“…The lymphatic system plays an important role in maintaining the fluid homeostasis between the blood vascular and interstitial tissue compartment and there is…”
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In vivo lymphatic imaging of a human inflammatory breast cancer model by Agollah, Germaine D, Wu, Grace, Sevick-Muraca, Eva M, Kwon, Sunkuk

“…Inflammatory breast cancer (IBC) remains the most aggressive type of breast cancer with the greatest potential for metastasis and as a result, the highest…”
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Direct visualization of changes of lymphatic function and drainage pathways in lymph node metastasis of B16F10 melanoma using near-infrared fluorescence imaging by Kwon, Sunkuk, Agollah, Germaine D, Wu, Grace, Chan, Wenyaw, Sevick-Muraca, Eva M

“…The lymphatic system provides an initial route for cancer cell dissemination in many cancers including melanoma. However, it is largely unknown how the…”
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Reduced Lysis upon Growth of Lactococcus lactis on Galactose Is a Consequence of Decreased Binding of the Autolysin AcmA by Steen, Anton, Buist, Girbe, Kramer, Naomi E, Jalving, Ruud, Benus, Germaine F.J.D, Venema, Gerard, Kuipers, Oscar P, Kok, Jan

“…When Lactococcus lactis subsp. lactis IL1403 or L. lactis subsp. cremoris MG1363 is grown in a medium with galactose as the carbon source, the culture lyses to…”
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Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells by Chang, Joseph, Bickford, Lissett R., Drezek, Rebekah, Agollah, Germaine D., Kennedy, Laura C., Langsner, Robert J.

“…Tumor margin detection for patients undergoing breast conservation surgery primarily occurs postoperatively. Previously, we demonstrated that gold nanoshells…”
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OS106. The postpartum preeclampsia clinic (PPPEC) – an interdisciplinary clinic for cardiovascular risk reduction for women with preeclampsia by Sia, W.W, Montgomery-Fajic, E, Germaine, D, Wilkie, J, Khurana, R, Marnoch, C, Nerenberg, K

“…Introduction Preeclampsia (PEC) is a well-established risk factor for the development of future premature cardiovascular disease (CVD). However, women with PEC…”
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COL3A1 mutations cause variable clinical phenotypes including acrogeria and vascular rupture by POPE, F. M., NARCISl, P., NICHOLLS, A.C., GERMAINE, D., PALS, G., RICHARDS, A. J.

“…Summary We have recently analysed by hislological, protein and molecular DNA techniques 23 mutations of the collagen III gene (COL3AI). most of which cause…”
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Pegozafermin, a FGF21 Analog, for the Treatment of Non-alcoholic Steatohepatitis (NASH) Patients with F2/F3 Fibrosis by Bhatt, Deepak L., Sanyal, Arun J., Harrison, Stephen A., Gottwald, Mildred D., Feng, Shibao, Agollah, Germaine D., Hartsfield, Cynthia L., Mansbach, Hank, Margalit, Maya, Loomba, Rohit

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SAT-203 Pegozafermin added to background GLP-1 therapy in patients with metabolic dysfunction-associated steatohepatitis with F2/F3 fibrosis: ENLIVEN 48-week extension data by Sanyal, Arun J., Abdelmalek, Manal F., Kowdley, Kris V., Alkhouri, Naim, Harrison, Stephen A., Schattenberg, Jörn M., Gottwald, Mildred D., Feng, Shibao, Agollah, Germaine D., Hartsfield, Cynthia L., Mansbach, Hank, Margalit, Maya, Loomba, Rohit

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OS-118 Week 48 results from the phase 2b ENLIVEN extension study investigating pegozafermin for the treatment of metabolic dysfunction-associated steatohepatitis with fibrosis by Loomba, Rohit, Abdelmalek, Manal F., Kowdley, Kris V., Alkhouri, Naim, Harrison, Stephen A., Schattenberg, Jörn M, Gottwald, Mildred D., Feng, Shibao, Agollah, Germaine D., Hartsfield, Cynthia L., Mansbach, Hank, Margalit, Maya, Sanyal, Arun J

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Pegozafermin Led to Significant Metabolic Benefits, in Addition to Robust Beneficial Effects on the Liver, in an Open-label Cohort of a Phase 1b/2a Study in Subjects with Non-alcoholic Steatohepatitis (NASH) by Alkhouri, Naim, Loomba, Rohit, Frias, Juan P., Feng, Shibao, Tseng, Leo, Agollah, Germaine D., Mansbach, Hank, Margalit, Maya, Hartsfield, Cynthia L., Harrison, Stephen

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Pegozafermin for the Treatment of Severe Hypertriglyceridemia: A Randomized, Double-blind, Placebo-controlled Phase 2 Study (ENTRIGUE STUDY) by Bhatt, Deepak L., Bays, Harold E., Miller, Michael, Parli, Teresa, Feng, Shibao, Sterling, Lulu, Hartsfield, Cynthia L., Agollah, Germaine D., Mansbach, Hank, Kastelein, John J.P.

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Pegozafermin Improved Liver Histology, Liver-related Non-invasive Tests (NITs) and Metabolic Profiles in an Open-label Cohort of a Phase 1b/2a Study in Subjects with Non-alcoholic Steatohepatitis by Loomba, Rohit, Alkhouri, Naim, Feng, Shibao, Tseng, Leo, Agollah, Germaine D., Mansbach, Hank, Margalit, Maya, Hartsfield, Cynthia L., Harrison, Stephen A.

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