Search Results - "Germain, Sean"

Age-Related Differences in Lower-Limb Muscle Cross-Sectional Area and Torque Production in Boys With Duchenne Muscular Dystrophy by Mathur, Sunita, PT, PhD, Lott, Donovan J., PT, PhD, Senesac, Claudia, PT, PhD, Germain, Sean A., MS, Vohra, Ravneet S., BSc(PT), Sweeney, H. Lee, PhD, Walter, Glenn A., PhD, Vandenborne, Krista, PT, PhD

“…Abstract Mathur S, Lott DJ, Senesac C, Germain SA, Vohra RS, Sweeney HL, Walter GA, Vandenborne K. Age-related differences in lower-limb muscle cross-sectional…”
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Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements by Vohra, Ravneet S, Lott, Donovan, Mathur, Sunita, Senesac, Claudia, Deol, Jasjit, Germain, Sean, Bendixen, Roxanna, Forbes, Sean C, Sweeney, H Lee, Walter, Glenn A, Vandenborne, Krista

“…The primary objectives of this study were to evaluate contractile and non-contractile content of lower leg muscles of boys with Duchenne muscular dystrophy…”
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Changes in muscle T2 and tissue damage after downhill running in mdx Mice by Mathur, Sunita, Vohra, Ravneet S., Germain, Sean A., Forbes, Sean, Bryant, Nathan D., Vandenborne, Krista, Walter, Glenn A.

“…Introduction: In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation…”
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Assessment of intramuscular lipid and metabolites of the lower leg using magnetic resonance spectroscopy in boys with Duchenne muscular dystrophy by Lott, Donovan J, Forbes, Sean C, Mathur, Sunita, Germain, Sean A, Senesac, Claudia R, Lee Sweeney, H, Walter, Glenn A, Vandenborne, Krista

“…Abstract The purpose of this study was to use proton magnetic resonance spectroscopy to assess intramuscular lipid and metabolites of lower leg muscles in boys…”
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Gel-mediated Delivery of AAV1 Vectors Corrects Ventilatory Function in Pompe Mice With Established Disease by Mah, Cathryn S, Falk, Darin J, Germain, Sean A, Kelley, Jeffry S, Lewis, Melissa A, Cloutier, Denise A, DeRuisseau, Lara R, Conlon, Thomas J, Cresawn, Kerry O, Fraites Jr, Thomas J, Campbell-Thompson, Martha, Fuller, David D, Byrne, Barry J

“…Pompe disease is a muscular dystrophy that results in respiratory insufficiency. We characterized the outcomes of targeted delivery of recombinant…”
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Physiological Correction of Pompe Disease by Systemic Delivery of Adeno-associated Virus Serotype 1 Vectors by Mah, Cathryn, Pacak, Christina A, Cresawn, Kerry O, DeRuisseau, Lara R, Germain, Sean, Lewis, Melissa A, Cloutier, Denise A, Fuller, David D, Byrne, Barry J

“…Pompe disease is caused by a lack of functional lysosomal acid α-glucosidase (GAA) and can ultimately lead to fatal hypertrophic cardiomyopathy and respiratory…”
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Long-term Skeletal Muscle Protection After Gene Transfer in a Mouse Model of LGMD-2D by Pacak, Christina A, Walter, Glenn A, Gaidosh, Gabe, Bryant, Nathan, Lewis, Melissa A, Germain, Sean, Mah, Cathryn S, Campbell, Kevin P, Byrne, Barry J

“…Limb girdle muscular dystrophy (LGMD) describes a group of inherited diseases resulting from mutations in genes encoding proteins involved in maintaining…”
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Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy by Akima, Hiroshi, Lott, Donovan, Senesac, Claudia, Deol, Jasjit, Germain, Sean, Arpan, Ishu, Bendixen, Roxanna, Lee Sweeney, H, Walter, Glenn, Vandenborne, Krista

“…Abstract The purpose of this study was to assess the contractile and non-contractile content in thigh muscles of patients with Duchenne muscular dystrophy…”
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PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats by Porvasnik, Stacy L, Germain, Sean, Embury, Jennifer, Gannon, Kimberley S, Jacques, Vincent, Murray, Justin, Byrne, Barry J, Shacham, Sharon, Al-Mousily, Faris

“…Pulmonary arterial hypertension (PAH) is a life-threatening disease that results in right ventricular failure…”
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Mitochondrial abnormalities, energy deficit and oxidative stress are features of calpain 3 deficiency in skeletal muscle by Kramerova, Irina, Kudryashova, Elena, Wu, Benjamin, Germain, Sean, Vandenborne, Krista, Romain, Nadine, Haller, Ronald G., Verity, M. Anthony, Spencer, Melissa J.

“…Mutations in the non-lysosomal cysteine protease calpain-3 cause autosomal recessive limb girdle muscular dystrophy. Pathological mechanisms occurring in this…”
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Adeno-associated virus-mediated correction of a canine model of glycogen storage disease type Ia by Weinstein, David A, Correia, Catherine E, Conlon, Thomas, Specht, Andrew, Verstegen, John, Onclin-Verstegen, Karine, Campbell-Thompson, Martha, Dhaliwal, Gurmeet, Mirian, Layla, Cossette, Holly, Falk, Darin J, Germain, Sean, Clement, Nathalie, Porvasnik, Stacy, Fiske, Laurie, Struck, Maggie, Ramirez, Harvey E, Jordan, Juan, Andrutis, Karl, Chou, Janice Y, Byrne, Barry J, Mah, Cathryn S

“…Glycogen storage disease type Ia (GSDIa; von Gierke disease; MIM 232200) is caused by a deficiency in glucose-6-phosphatase-alpha. Patients with GSDIa are…”
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NNLS Analyses Of Skeletal Muscle T2 In Children With Duchenne Muscular Dystrophy: 2810 Board #161 June 4 3:30 PM - 5:00 PM by Forbes, Sean C., Germain, Sean, Lott, Donovan J., Vandenborne, Krista, Walter, Glenn A.

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Skeletal Muscle Contractile And Non-contractile Components In Boys With Duchenne Muscular Dystrophy By Mri: 2999 Board #102 June 5 8:00 AM - 9:30 AM by Akima, Hiroshi, Deol, Jasjit, Germain, Sean, Senesac, Claudia, Lott, Donovan, Bendixen, Roxanna, Walter, Glenn, Vandenborne, Krista

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CHANGES IN MUSCLE T2 AND TISSUE DAMAGE FOLLOWING DOWNHILL RUNNING IN MDX MICE by Mathur, Sunita, Vohra, Ravneet S., Germain, Sean A., Forbes, Sean, Bryant, Nathan D., Vandenborne, Krista, Walter, Glenn A.

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Muscle Pathology and Functional Ability in Children with Duchenne Muscular Dystrophy: 2977 Board #80 June 5 8:00 AM - 9:30 AM by Deol, Jasjit K., Schmalfuss, Ilona, Lott, Donovan J., Germain, Sean A., Mathur, Sunita, Senesac, Claudia, Walter, Glenn A., Vandenborne, Krista

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Distribution Of T2 In The Soleus Muscle Of Children With Duchenne Muscular Dystrophy: 2667 Board #18 June 4 2:00 PM - 3:30 PM by Arpan, Ishu, Forbes, Sean C., Lott, Donovan, Germain, Sean, Sukumar, Mahesh, Senesac, Claudia, Walter, Glenn A., Vandenborne, Krista

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Developing an MRI based method for analyzing differences in blood vessel diameter and brain tissue perfusion in hypertension by Gillies, Robert Milne, Germain, Sean, Raizada, Mohan, Paton, Julian, Walter, Glenn

“…Abstract only We aimed to develop an MRI based protocol to investigate anatomical differences in brainstem blood vessels between spontaneously hypertensive…”
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Next generation treatment of Pompe disease using systemic gene transfer with AAV9 by Falk, Darin, Soustek, Meghan S., Mah, Cathryn S., Cloutier, Denise A., Germain, Sean A., Kelley, Jeffry S., Erger, Kirsten E., Conlon, Thomas J., Clement, Nathalie, Byrne, Barry J.

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Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD by Beattie, Stuart G, Goetzman, Eric, Conlon, Thomas, Germain, Sean, Walter, Glenn, Campbell-Thompson, Martha, Matern, Dietrich, Vockley, Jerry, Flotte, Terence R

“…Recombinant adeno-associated viral vectors pseudotyped with serotype 5 and 8 capsids (AAV5 and AAV8) have been shown to be efficient gene transfer reagents for…”
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28. rAAV2/9 Mediated Gene Delivery of Acid [alpha]-Glucosidase Corrects the Cardiac Phenotype in a Mouse Model of Pompe Disease by Pacak, Christina A, Mah, Cathryn, Cresawn, Kerry O, Lewis, Melissa A, Germain, Sean, Byrne, Barry J

“…The long term goal of this project is to develop a clinically relevant gene therapy approach for the treatment of Pompe Disease. Pompe Disease is a form of…”
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