Search Results - "Germain, Sandra J."

Gene Expression of Acyl Coenzyme A: Cholesterol Acyltransferase Is Upregulated in Human Monocytes During Differentiation and Foam Cell Formation by Wang, Hongxing, Germain, Sandra J, Benfield, Pamela P, Gillies, Peter J

“…The gene expression and enzyme kinetics of acyl coenzyme A:cholesterol acyltransferase (ACAT) were investigated in human monocytes, macrophages, and foam…”
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Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole by Wilde, Richard G., Billheimer, Jeffrey T., Germain, Sandra J., Gillies, Peter J., Higley, C.Anne, Kezar, Hollis S., Maduskuie, Thomas P., Shimshick, Edward S., Wexler, Ruth R.

“…A series of compounds bearing heterocyclic substituents were prepared, and evaluated for inhibition of the ACAT enzyme. The heterocyclic groups were compared…”
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DMP 504, a novel hydrogel bile acid sequestrant: II. Lipid-lowering pharmacology in the hamster by Gillies, Peter J., Billheimer, Jeffrey T., Blackston, Verdell A., Cromley, Debra A., Figuly, Garret D., Fischer, Robert T., Germain, Sandra J., Godonis, Helen E., Gorko, Mary A., Grimminger, Lisa C., Harvey, Susan J., Jensen, James H., Kieras, Cathy J., Royce, Susan D., Pautler, Henry C., Shimshick, Edward J., Stevenson, Rosanne C., Hainer, James W.

“…DMP 504 is a novel hydrogel bile acid sequestrant in development for the treatment of moderate hypercholesterolemia. The drug is a condensation polymer…”
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