Search Results - "Germain, Ronald N."

Strategically Localized Dendritic Cells Promote Rapid T Cell Responses to Lymph-Borne Particulate Antigens by Gerner, Michael Y., Torabi-Parizi, Parizad, Germain, Ronald N.

“…Upon infection, adaptive immune responses play catch-up with rapidly replicating pathogens. While mechanisms for efficient humoral responses to lymph-borne…”
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The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation by Subramanian, Naeha, Natarajan, Kannan, Clatworthy, Menna R., Wang, Ze, Germain, Ronald N.

“…NLRP3 is a key component of the macromolecular signaling complex called the inflammasome that promotes caspase 1-dependent production of IL-1β. The adaptor ASC…”
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A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread by Kastenmüller, Wolfgang, Torabi-Parizi, Parizad, Subramanian, Naeha, Lämmermann, Tim, Germain, Ronald N.

“…The lymphatic network that transports interstitial fluid and antigens to lymph nodes constitutes a conduit system that can be hijacked by invading pathogens to…”
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A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection by Brandes, Marlène, Klauschen, Frederick, Kuchen, Stefan, Germain, Ronald N.

“…For acutely lethal influenza infections, the relative pathogenic contributions of direct viral damage to lung epithelium versus dysregulated immunity remain…”
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T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo by van Panhuys, Nicholas, Klauschen, Frederick, Germain, Ronald N.

“…Polarization of effector CD4+ T cells can be influenced by both antigen-specific signals and by pathogen- or adjuvant-induced cytokines, with current models…”
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Histo-Cytometry: A Method for Highly Multiplex Quantitative Tissue Imaging Analysis Applied to Dendritic Cell Subset Microanatomy in Lymph Nodes by Gerner, Michael Y., Kastenmuller, Wolfgang, Ifrim, Ina, Kabat, Juraj, Germain, Ronald N.

“…Flow cytometry allows highly quantitative analysis of complex dissociated populations at the cost of neglecting their tissue localization. In contrast,…”
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Intravital and high-content multiplex imaging of the immune system by Hor, Jyh Liang, Germain, Ronald N.

“…Highly motile and functionally diverse immune cells orchestrate effective immune responses through complex and dynamic cooperative behavior. Multiphoton…”
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Stromal cell contributions to the homeostasis and functionality of the immune system by Mueller, Scott N, Germain, Ronald N

“…Key Points The immune system combats invading pathogens with a broad cellular and molecular arsenal. Integral to this defence are secondary lymphoid organs…”
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Superpenetration optical microscopy by iterative multiphoton adaptive compensation technique by Tang, Jianyong, Germain, Ronald N, Cui, Meng

“…Biological tissues are rarely transparent, presenting major challenges for deep tissue optical microscopy. The achievable imaging depth is fundamentally…”
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A Decade of Imaging Cellular Motility and Interaction Dynamics in the Immune System by Germain, Ronald N., Robey, Ellen A., Cahalan, Michael D.

“…To mount an immune response, lymphocytes must recirculate between the blood and lymph nodes, recognize antigens upon contact with specialized presenting cells,…”
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S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense by Huang, Yuefeng, Mao, Kairui, Chen, Xi, Sun, Ming-An, Kawabe, Takeshi, Li, Weizhe, Usher, Nicholas, Zhu, Jinfang, Urban, Jr, Joseph F, Paul, William E, Germain, Ronald N

“…Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing to host defense, tissue repair, metabolic homeostasis, and…”
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Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node by Kastenmüller, Wolfgang, Brandes, Marlene, Wang, Ze, Herz, Jasmin, Egen, Jackson G., Germain, Ronald N.

“…After an infection, the immune system generates long-lived memory lymphocytes whose increased frequency and altered state of differentiation enhance host…”
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Spatiotemporal Basis of Innate and Adaptive Immunity in Secondary Lymphoid Tissue by Qi, Hai, Kastenmüller, Wolfgang, Germain, Ronald N

“…Secondary lymphoid tissues are the sites of both innate and adaptive host defense. Aside from the relatively static nonhematopoietic stromal elements and some…”
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The multiple faces of leukocyte interstitial migration by Lämmermann, Tim, Germain, Ronald N.

“…Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate and adaptive immune responses. Homeostatic trafficking and…”
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Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo by Lämmermann, Tim, Afonso, Philippe V., Angermann, Bastian R., Wang, Ji Ming, Kastenmüller, Wolfgang, Parent, Carole A., Germain, Ronald N.

“…Two-photon intravital imaging is used here to define the regulation of interstitial neutrophil migration at local sites of cell death upon sterile tissue…”
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T Cell-Positive Selection Uses Self-Ligand Binding Strength to Optimize Repertoire Recognition of Foreign Antigens by Mandl, Judith N., Monteiro, João P., Vrisekoop, Nienke, Germain, Ronald N.

“…Developing T cells express diverse antigen receptors whose specificities are not prematched to the foreign antigens they eventually encounter. Past experiments…”
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Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance by Freeman, Spencer A, Uderhardt, Stefan, Saric, Amra, Collins, Richard F, Buckley, Catherine M, Mylvaganam, Sivakami, Boroumand, Parastoo, Plumb, Jonathan, Germain, Ronald N, Ren, Dejian, Grinstein, Sergio

“…Despite ongoing (macro)pinocytosis of extracellular fluid, the volume of the endocytic pathway remains unchanged. To investigate the underlying mechanism, we…”
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The lymph node at a glance - how spatial organization optimizes the immune response by Grant, Spencer M, Lou, Meng, Yao, Li, Germain, Ronald N, Radtke, Andrea J

“…A hallmark of the mammalian immune system is its ability to respond efficiently to foreign antigens without eliciting an inappropriate response to…”
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Antigen- and Cytokine-Driven Accumulation of Regulatory T Cells in Visceral Adipose Tissue of Lean Mice by Kolodin, Dmitriy, van Panhuys, Nicolas, Li, Chaoran, Magnuson, Angela M., Cipolletta, Daniela, Miller, Christine M., Wagers, Amy, Germain, Ronald N., Benoist, Christophe, Mathis, Diane

“…A unique population of Foxp3+CD4+ regulatory T (Treg) cells, with a distinct transcriptome and antigen-receptor repertoire, resides in visceral adipose tissue…”
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Tuning of Antigen Sensitivity by T Cell Receptor-Dependent Negative Feedback Controls T Cell Effector Function in Inflamed Tissues by Honda, Tetsuya, Egen, Jackson G., Lämmermann, Tim, Kastenmüller, Wolfgang, Torabi-Parizi, Parizad, Germain, Ronald N.

“…Activated T cells must mediate effector responses sufficiently to clear pathogens while avoiding excessive tissue damage. Here we have combined dynamic…”
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