Search Results - "Germain, Matthieu"

Delivering the power of nanomedicine to patients today by Germain, Matthieu, Caputo, Fanny, Metcalfe, Su, Tosi, Giovanni, Spring, Kathleen, Åslund, Andreas K.O., Pottier, Agnes, Schiffelers, Raymond, Ceccaldi, Alexandre, Schmid, Ruth

“…The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified…”
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MRI contrast variation of thermosensitive magnetoliposomes triggered by focused ultrasound: a tool for image-guided local drug delivery by Lorenzato, Cyril, Cernicanu, Alexandru, Meyre, Marie-Edith, Germain, Matthieu, Pottier, Agnès, Levy, Laurent, de Senneville, Baudouin Denis, Bos, Clemens, Moonen, Chrit, Smirnov, Pierre

“…Improved drug delivery control during chemotherapy has the potential to increase the therapeutic index. MRI contrast agent such as iron oxide nanoparticles can…”
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A Nanoprimer To Improve the Systemic Delivery of siRNA and mRNA by Saunders, Nell R M, Paolini, Marion S, Fenton, Owen S, Poul, Laurence, Devalliere, Julie, Mpambani, Francis, Darmon, Audrey, Bergère, Maxime, Jibault, Océane, Germain, Matthieu, Langer, Robert

“…Despite tremendous interest in gene therapies, the systemic delivery of nucleic acids still faces substantial challenges. To successfully administer nucleic…”
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Abstract 3613: Mononuclear phagocytic system occupancy to increase nanomedicines based treatment efficacy by germain, matthieu, Poul, Laurence, Devalliere, Julie, Paolini, Marion, Darmon, Audrey, Bergere, Maxime, Jibault, Oceane, Mpambani, Francis

“…Abstract Introduction: To efficiently deliver treatment, nanomedicines must exhibit sufficient blood bioavailability for further accumulation at the target…”
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Abstract 2871: The Nanoprimer: a nanoparticle designed to transiently occupy the mononuclear phagocytic system in order to increase nanomedicine-based treatments efficacy by Devalliere, Julie, Poul, Laurence, Darmon, Audrey, Jibault, Oceane, Bergere, Maxime, Mpambani, Francis, Saunders, Nell, Paolini, Marion, Langer, Robert, Germain, Matthieu

“…Abstract Introduction: Most nanomedicines are currently limited in their efficacy due to a sub-optimal biodistribution/accumulation in the target tissues. A…”
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Abstract 3902: The Nanoprimer: A significant opportunity to boost the efficacy of cancer therapies by Devallière, Julie, Poul, Laurence, Bergère, Maxime, Mpambani, Francis, Darmon, Audrey, Jibault, Océane, Germain, Matthieu

“…Abstract Nanomedicines are among the most promising novel delivery systems and are highly promising as therapeutic agents in oncology. However, their use is…”
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A translational framework to DELIVER nanomedicines to the clinic by Joyce, Paul, Allen, Christine J., Alonso, María José, Ashford, Marianne, Bradbury, Michelle S., Germain, Matthieu, Kavallaris, Maria, Langer, Robert, Lammers, Twan, Peracchia, Maria Teresa, Popat, Amirali, Prestidge, Clive A., Rijcken, Cristianne J. F., Sarmento, Bruno, Schmid, Ruth B., Schroeder, Avi, Subramaniam, Santhni, Thorn, Chelsea R., Whitehead, Kathryn A., Zhao, Chun-Xia, Santos, Hélder A.

“…Nanomedicines have created a paradigm shift in healthcare. Yet fundamental barriers still exist that prevent or delay the clinical translation of…”
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Abstract LB-072: Redefine nanomedicine products bioavailability to improve anti-tumor efficacy by Germain, Matthieu, Poul, Laurence, Meyre, Marie-Edith, Paolini, Marion, Mpambani, Francis, Bergere, Maxime, Pottier, Agnes, Levy, Laurent

“…Abstract Introduction: The benefit of a nanomedicine is due to its bioavailability, its intrinsic efficacy balanced with its toxicity profile. The nanomedicine…”
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A new opportunity for nanomedicines: Micellar cytochrome P450 inhibitors to improve drug efficacy in a cancer therapy model by Paolini, Marion, Poul, Laurence, Darmon, Audrey, Germain, Matthieu, Pottier, Agnès, Levy, Laurent, Vibert, Eric

“…Abstract Nanomedicines are mainly used as drug delivery systems; here we evaluate a new application - to inhibit a drug's metabolism thereby enhancing its…”
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Abstract 3295: The Nanoprimer: A nanoparticle designed to the efficacy of nucleic acid-based therapeutics in oncology by Devallière, Julie, Poul, Laurence, Bergère, Maxime, Darmon, Audrey, Jibault, Océane, Mpambani, Francis, Tsai, Kelvin, Germain, Matthieu

“…Abstract Nucleic acid drugs have shown promise in oncology, however their use is limited by hepatic clearance. Due to the mononuclear phagocytic system (MPS),…”
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Priming the body to receive the therapeutic agent to redefine treatment benefit/risk profile by Germain, Matthieu, Meyre, Marie-Edith, Poul, Laurence, Paolini, Marion, Berjaud, Céline, Mpambani, Francis, Bergere, Maxime, Levy, Laurent, Pottier, Agnès

“…Many therapeutic agents offer a low useful dose (dose responsible for efficacy)/useless dose (dose eliminated or responsible for toxicity) ratio, mainly due to…”
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Mannose-modified hyaluronic acid nanocapsules for the targeting of tumor-associated macrophages by Fernández-Mariño, Iago, Anfray, Clément, Crecente-Campo, Jose, Maeda, Akihiro, Ummarino, Aldo, Teijeiro-Valiño, Carmen, Blanco-Martinez, Dario, Mpambani, Francis, Poul, Laurence, Devalliere, Julie, Germain, Matthieu, Correa, Juan, Fernandez-Villamarin, Marcos, Allavena, Paola, Fernandez-Megia, Eduardo, Alonso, María José, Andón, Fernando Torres

“…Tumor-associated macrophages (TAMs), a class of immune cells that play a key role in tumor immunosuppression, are recognized as important targets to improve…”
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Nano-sized cytochrome P450 3A4 inhibitors to block hepatic metabolism of docetaxel by Paolini, Marion, Poul, Laurence, Berjaud, Céline, Germain, Matthieu, Darmon, Audrey, Bergère, Maxime, Pottier, Agnès, Levy, Laurent, Vibert, Eric

“…Most drugs are metabolized by hepatic cytochrome P450 3A4 (CYP3A4), resulting in their reduced bioavailability. In this study, we present the design and…”
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Pp IX Silica Nanoparticles Demonstrate Differential Interactions with In Vitro Tumor Cell Lines and In Vivo Mouse Models of Human Cancers by Simon, Virginie, Devaux, Corinne, Darmon, Audrey, Donnet, Thibault, Thiénot, Edouard, Germain, Matthieu, Honnorat, Jérôme, Duval, Alex, Pottier, Agnès, Borghi, Elsa, Levy, Laurent, Marill, Julie

“…Protoporphyrin IX (Pp IX) silica nanoparticles, developed for effective use in photodynamic therapy (PDT), were explored in in vitro and in vivo models with…”
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Protection of mammalian cell used in biosensors by coating with a polyelectrolyte shell by Germain, Matthieu, Balaguer, Patrick, Nicolas, Jean-Claude, Lopez, Frederic, Esteve, Jean-Pierre, Sukhorukov, Gleb B., Winterhalter, Mathias, Richard-Foy, Hélène, Fournier, Didier

“…In order to detect xenoestrogens which induce perturbations of mammalian cells, design of biosensor using a mammalian cell line enable to detect these…”
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Ultrasound-induced temperature elevation for in-vitro controlled release of temperature-sensitive liposomes by Mannaris, Christophoros, Efthymiou, Eleni, Escoffre, Jean-Michel, Bouakaz, Ayache, Meyre, Marie-Edith, Germain, Matthieu, Averkiou, Michalakis A.

“…Drug loaded temperature-sensitive liposomes (TSLs) release their payload with mild hyperthermia near their phase transition temperature (Tm = 43–45 °C). Such a…”
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Composite Nanocapsules: Lipid Vesicles Covered with Several Layers of Crosslinked Polyelectrolytes by Germain, M., Grube, S., Carriere, V., Richard-Foy, H., Winterhalter, M., Fournier, D.

“…Biologically active proteins are loaded into liposomes, which are then used as templates for the layer‐by‐layer deposition of polyelectrolytes. The multilayer…”
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One pot synthesis of new hybrid versatile nanocarrier exhibiting efficient stability in biological environment for use in photodynamic therapy by Thienot, Edouard, Germain, Matthieu, Piejos, Kelthoum, Simon, Virginie, Darmon, Audrey, Marill, Julie, Borghi, Elsa, Levy, Laurent, Hochepied, Jean-François, Pottier, Agnès

“…A new versatile hybrid nanocarrier has been designed using a “soft chemistry” synthesis, to efficiently encapsulate a photosensitizer – the protoporphyrin IX…”
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Inactivation of the 3′-5′ Exonuclease of the Replicative T4 DNA Polymerase Allows Translesion DNA Synthesis at an Abasic Site by Le Gac, Nicolas Tanguy, Delagoutte, Emmanuelle, Germain, Matthieu, Villani, Giuseppe

“…Here, we have investigated the consequences of the loss of proof-reading exonuclease function on the ability of the replicative T4 DNA polymerase (gp43) to…”
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Liposome-based nanocapsules by Ruysschaert, T., Germain, M., da Silva Gomes, J.F.P., Fournier, D., Sukhorukov, G.B., Meier, W., Winterhalter, M.

“…Here we present three different types of mechanically stable nanometer-sized hollow capsules. The common point of the currently developed systems in our…”
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