Search Results - "Gerlach, Raquel F"

Matrix Metalloproteinases and Arterial Hypertension: Role of Oxidative Stress and Nitric Oxide in Vascular Functional and Structural Alterations by Prado, Alejandro F, Batista, Rose I M, Tanus-Santos, Jose E, Gerlach, Raquel F

“…Various pathophysiological mechanisms have been implicated in hypertension, but those resulting in vascular dysfunction and remodeling are critical and may…”
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Matrix metalloproteinase-2-induced epidermal growth factor receptor transactivation impairs redox balance in vascular smooth muscle cells and facilitates vascular contraction by Prado, Alejandro F., Pernomian, Laena, Azevedo, Aline, Costa, Rute A.P., Rizzi, Elen, Ramos, Junia, Paes Leme, Adriana F., Bendhack, Lusiane M., Tanus-Santos, Jose E., Gerlach, Raquel F.

“…Increased reactive oxygen species (ROS) formation may enhance matrix metalloproteinase (MMP)-2 activity and promote cardiovascular dysfunction. We show for the…”
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Doxycycline Decreases Atherosclerotic Lesions in the Aorta of ApoE -⁄- and Ovariectomized Mice with Correlation to Reduced MMP-2 Activity by Rodrigues, Keuri E, Azevedo, Aline, Gonçalves, Pricila R, Pontes, Maria H B, Alves, Gustavo M, Oliveira, Ruan R, Amarante, Cristine B, Issa, João P M, Gerlach, Raquel F, Prado, Alejandro F

“…Atherogenic events promote changes in vessel walls, with alteration of the redox state, and increased activity of matrix metalloproteinases (MMPs). Thus, this…”
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Gingival crevicular fluid levels of MMP-8, MMP-9, TIMP-2, and MPO decrease after periodontal therapy by Marcaccini, Andrea M., Meschiari, Cesar A., Zuardi, Leonardo R., De Sousa, Tiago Sampaio, Taba Jr, Mario, Teofilo, Juliana M., Jacob-Ferreira, Anna L.B., Tanus-Santos, Jose E., Novaes Jr, Arthur B., Gerlach, Raquel F.

“…Marcaccini AM, Meschiari CA, Zuardi LR, de Sousa TS, Taba M, Teofilo JM, Jacob‐Ferreira ALB, Tanus‐Santos JE, Novaes AB, Gerlach RF. Gingival crevicular fluid…”
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Circulating Interleukin‐6 and High‐Sensitivity C‐Reactive Protein Decrease After Periodontal Therapy in Otherwise Healthy Subjects by Marcaccini, Andrea M., Meschiari, César A., Sorgi, Carlos A., Saraiva, Maria C.P., de Souza, Ana M., Faccioli, Lúcia H., Tanus‐Santos, José E., Novaes, Arthur B., Gerlach, Raquel F.

“…Background: Periodontal disease has been associated with many chronic inflammatory systemic diseases, and a common chronic inflammation pathway has been…”
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Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy by Marcaccini, Andrea M., Novaes, Arthur B., Meschiari, Cesar A., Souza, Sergio L., Palioto, Daniela B., Sorgi, Carlos A., Faccioli, Lucia H., Tanus-Santos, Jose E., Gerlach, Raquel F.

“…Periodontal disease shares risk factors with cardiovascular diseases and other systemic inflammatory diseases. The present study was designed to assess the…”
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Consistent Alterations of Circulating Matrix Metalloproteinases Levels in Untreated Hypertensives and in Spontaneously Hypertensive Rats: A Relevant Pharmacological Target by Fontana, Vanessa, Silva, Pamela S., Belo, Vanessa A., Antonio, Raquel C., Ceron, Carla S., Biagi, Celso, Gerlach, Raquel F., Tanus‐Santos, Jose E.

“…:  Inconsistent matrix metalloproteinases (MMPs) levels have been reported in hypertension, with higher, similar and lower MMPs levels reported in…”
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Atorvastatin and sildenafil lower blood pressure and improve endothelial dysfunction, but only atorvastatin increases vascular stores of nitric oxide in hypertension by Guimarães, Danielle A, Rizzi, Elen, Ceron, Carla S, Pinheiro, Lucas C, Gerlach, Raquel F, Tanus-Santos, Jose E

“…Nitric oxide (NO)-derived metabolites including the anion nitrite can recycle back to NO and thus complement NO formation independent of NO synthases. While…”
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Evidence for the involvement of matrix metalloproteinases in the cardiovascular effects produced by nicotine by Jacob-Ferreira, Anna L.B., Palei, Ana C.T., Cau, Stefany B., Moreno, Heitor, Martinez, Marcio L.L., Izidoro-Toledo, Tatiane C., Gerlach, Raquel F., Tanus-Santos, Jose E.

“…Nicotine plays a role in smoking-associated cardiovascular diseases, and may upregulate matrix metalloproteinase (MMP)-2 and MMP-9. We examined whether…”
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Haplotypes of vitamin D receptor modulate the circulating levels of lead in exposed subjects by Rezende, Vania B., Barbosa, Fernando, Montenegro, Marcelo F., Sandrim, Valeria C., Gerlach, Raquel F., Tanus-Santos, Jose E.

“…Genetic factors influence whole blood lead (Pb-B) concentrations in lead exposed subjects. This study aimed at examining the combined effects (haplotype…”
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L-arginine attenuates acute pulmonary embolism-induced increases in lung matrix metalloproteinase-2 and matrix metalloproteinase-9 by Souza-Costa, Debora C, Zerbini, Talita, Palei, Ana C, Gerlach, Raquel F, Tanus-Santos, Jose E

“…To evaluate the effects of L-arginine on acute pulmonary embolism (APE)-induced pulmonary hypertension and increases in lung matrix metalloproteinase (MMP)-2…”
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Matrix metalloproteinases: Targets for doxycycline to prevent the vascular alterations of hypertension by Castro, Michele M., Tanus-Santos, Jose E., Gerlach, Raquel F.

“…Hypertension is associated with well known structural and functional alterations in both resistance and conduit arteries, which may be the result from…”
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A polymorphism in the delta-aminolevulinic acid dehydratase gene modifies plasma/whole blood lead ratio by MONTENEGRO, Marcelo F, BARBOSA, Fernando, SANDRIM, Valeria C, GERLACH, Raquel F, TANUS-SANTOS, Jose E

“…Delta aminolevulinic acid dehydratase (ALAD) plays an important role in lead poisoning. This study was carried out to examine the effects of ALAD gene…”
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Matrix Metalloproteinases are Involved in Cardiovascular Diseases by Azevedo, Aline, Prado, Alejandro F., Antonio, Raquel C., Issa, Joao P., Gerlach, Raquel F.

“…This MiniReview describes the essential biochemical and molecular aspects of matrix metalloproteinases (MMPs) and briefly discusses how they engage in…”
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Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-β and MMPs, and decreases vascular remodeling in renovascular hypertension by Ceron, Carla S, Rizzi, Elen, Guimarães, Danielle A, Martins-Oliveira, Alisson, Gerlach, Raquel F, Tanus-Santos, Jose E

“…Nebivolol and metoprolol are β₁-adrenergic receptor blockers with different properties. We hypothesized that nebivolol, but not metoprolol, could attenuate…”
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An interethnic comparison of the distribution of vitamin D receptor genotypes and haplotypes by Rezende, Vania B., Barbosa, Fernando, Montenegro, Marcelo F., Sandrim, Valeria C., Gerlach, Raquel F., Tanus-Santos, Jose E.

“…The biological actions of vitamin D receptor (VDR) may be affected by genetic variations in the VDR gene. While there are interethnic differences in the…”
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Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy by Guimaraes, Danielle A., dos Passos, Madla A., Rizzi, Elen, Pinheiro, Lucas C., Amaral, Jefferson H., Gerlach, Raquel F., Castro, Michele M., Tanus-Santos, Jose E.

“…Cardiac hypertrophy is a common consequence of chronic hypertension and leads to heart failure and premature death. The anion nitrite is now considered as a…”
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Temporomandibular inflammation regulates the matrix metalloproteinases MMP‐2 and MMP‐9 in limbic structures by Nascimento, Glauce C., De Paula, Bruna B., Gerlach, Raquel F., Leite‐Panissi, Christie R. A.

“…Temporomandibular disorder (TMD) is characterized by acute or chronic orofacial pain, which can be associated with inflammatory processes in the…”
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Antioxidant treatment reduces matrix metalloproteinase-2-induced vascular changes in renovascular hypertension by Castro, Michele M., Rizzi, Elen, Rodrigues, Gerson J., Ceron, Carla S., Bendhack, Lusiane M., Gerlach, Raquel F., Tanus-Santos, Jose E.

“…Mounting evidence indicates that structural and functional vascular changes associated with two-kidney, one-clip (2K-1C) hypertension result, at least in part,…”
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Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects by Rizzi, Elen, Amaral, Jefferson H., Guimarães, Danielle A., Conde-Tella, Sandra O., Pinheiro, Lucas C., Gerlach, Raquel F., Castro, Michele M., Tanus-Santos, Jose E.

“…Hypertension is associated with cardiovascular remodeling. Given that impaired redox state activates matrix metalloproteinase (MMP)− 2 and promotes vascular…”
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