Search Results - "Gerke, Julia S"

Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets by Baldauf, Michaela C, Orth, Martin F, Dallmayer, Marlene, Marchetto, Aruna, Gerke, Julia S, Rubio, Rebeca Alba, Kiran, Merve M, Musa, Julian, Knott, Maximilian M L, Ohmura, Shunya, Li, Jing, Akpolat, Nusret, Akatli, Ayse N, Özen, Özlem, Dirksen, Uta, Hartmann, Wolfgang, de Alava, Enrique, Baumhoer, Daniel, Sannino, Giuseppina, Kirchner, Thomas, Grünewald, Thomas G P

“…Ewing sarcoma is an undifferentiated small-round-cell sarcoma. Although molecular detection of pathognomonic fusions such as enables definitive diagnosis,…”
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Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma by Orth, Martin F., Gerke, Julia S., Knösel, Thomas, Altendorf‐Hofmann, Annelore, Musa, Julian, Alba‐Rubio, Rebeca, Stein, Stefanie, Hölting, Tilman L. B., Cidre‐Aranaz, Florencia, Romero‐Pérez, Laura, Dallmayer, Marlene, Baldauf, Michaela C., Marchetto, Aruna, Sannino, Giuseppina, Knott, Maximilian M. L., Wehweck, Fabienne, Ohmura, Shunya, Li, Jing, Hakozaki, Michiyuki, Kirchner, Thomas, Dandekar, Thomas, Butt, Elke, Grünewald, Thomas G. P.

“…Soft‐tissue sarcomas are rare, heterogeneous, and often aggressive mesenchymal cancers. Many of them are associated with poor outcome, partially because…”
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Focal adhesion kinase confers pro‐migratory and antiapoptotic properties and is a potential therapeutic target in Ewing sarcoma by Steinestel, Konrad, Trautmann, Marcel, Jansen, Esther‐Pia, Dirksen, Uta, Rehkämper, Jan, Mikesch, Jan‐Henrik, Gerke, Julia S., Orth, Martin F., Sannino, Giuseppina, Arteaga, Maria‐Francisca, Rossig, Claudia, Wardelmann, Eva, Grünewald, Thomas G. P., Hartmann, Wolfgang

“…Oncogenesis of Ewing sarcoma (EwS), the second most common malignant bone tumor of childhood and adolescence, is dependent on the expression of chimeric…”
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Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas? by Baldauf, Michaela C., Gerke, Julia S., Orth, Martin F., Dallmayer, Marlene, Baumhoer, Daniel, de Alava, Enrique, Hartmann, Wolfgang, Kirchner, Thomas, Grünewald, Thomas G.P.

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Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes by Musa, Julian, Cidre-Aranaz, Florencia, Aynaud, Marie-Ming, Orth, Martin F., Knott, Maximilian M. L., Mirabeau, Olivier, Mazor, Gal, Varon, Mor, Hölting, Tilman L. B., Grossetête, Sandrine, Gartlgruber, Moritz, Surdez, Didier, Gerke, Julia S., Ohmura, Shunya, Marchetto, Aruna, Dallmayer, Marlene, Baldauf, Michaela C., Stein, Stefanie, Sannino, Giuseppina, Li, Jing, Romero-Pérez, Laura, Westermann, Frank, Hartmann, Wolfgang, Dirksen, Uta, Gymrek, Melissa, Anderson, Nathaniel D., Shlien, Adam, Rotblat, Barak, Kirchner, Thomas, Delattre, Olivier, Grünewald, Thomas G. P.

“…Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations except for pathognomonic driver-mutations that cannot explain…”
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Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation by Orth, Martin F., Surdez, Didier, Faehling, Tobias, Ehlers, Anna C., Marchetto, Aruna, Grossetête, Sandrine, Volckmann, Richard, Zwijnenburg, Danny A., Gerke, Julia S., Zaidi, Sakina, Alonso, Javier, Sastre, Ana, Baulande, Sylvain, Sill, Martin, Cidre-Aranaz, Florencia, Ohmura, Shunya, Kirchner, Thomas, Hauck, Stefanie M., Reischl, Eva, Gymrek, Melissa, Pfister, Stefan M., Strauch, Konstantin, Koster, Jan, Delattre, Olivier, Grünewald, Thomas G.P.

“…Ewing sarcoma (EwS) is characterized by EWSR1-ETS fusion transcription factors converting polymorphic GGAA microsatellites (mSats) into potent neo-enhancers…”
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Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma by Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by…”
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Integrative clinical transcriptome analysis reveals TMPRSS2‐ERG dependency of prognostic biomarkers in prostate adenocarcinoma by Gerke, Julia S., Orth, Martin F., Tolkach, Yuri, Romero‐Pérez, Laura, Wehweck, Fabienne S., Stein, Stefanie, Musa, Julian, Knott, Maximilian M.L., Hölting, Tilman L.B., Li, Jing, Sannino, Giuseppina, Marchetto, Aruna, Ohmura, Shunya, Cidre‐Aranaz, Florencia, Müller‐Nurasyid, Martina, Strauch, Konstantin, Stief, Christian, Kristiansen, Glen, Kirchner, Thomas, Buchner, Alexander, Grünewald, Thomas G.P.

“…In prostate adenocarcinoma (PCa), distinction between indolent and aggressive disease is challenging. Around 50% of PCa are characterized by TMPRSS2‐ERG…”
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Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas? by Baldauf, Michaela C., Gerke, Julia S., Orth, Martin F., Dallmayer, Marlene, Baumhoer, Daniel, de Alava, Enrique, Hartmann, Wolfgang, Kirchner, Thomas, Grünewald, Thomas G. P.

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Publisher Correction: Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma by Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20017-2…”
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High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma by Orth, Martin F, Hölting, Tilman L B, Dallmayer, Marlene, Wehweck, Fabienne S, Paul, Tanja, Musa, Julian, Baldauf, Michaela C, Surdez, Didier, Delattre, Olivier, Knott, Maximilian M L, Romero-Pérez, Laura, Kasan, Merve, Cidre-Aranaz, Florencia, Gerke, Julia S, Ohmura, Shunya, Li, Jing, Marchetto, Aruna, Henssen, Anton G, Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Kanaseki, Takayuki, Bertram, Stefanie, Dirksen, Uta, Hartmann, Wolfgang, Kirchner, Thomas, Grünewald, Thomas G P

“…Ewing sarcoma (EwS) is an aggressive cancer displaying an undifferentiated small-round-cell histomorphology that can be easily confused with a broad spectrum…”
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Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma by Dallmayer, Marlene, Li, Jing, Ohmura, Shunya, Alba Rubio, Rebeca, Baldauf, Michaela C., Hölting, Tilman L. B., Musa, Julian, Knott, Max M. L., Stein, Stefanie, Cidre-Aranaz, Florencia, Wehweck, Fabienne S., Romero-Pérez, Laura, Gerke, Julia S., Orth, Martin F., Marchetto, Aruna, Kirchner, Thomas, Bach, Horacio, Sannino, Giuseppina, Grünewald, Thomas G. P.

“…Ewing sarcoma (EwS) is an aggressive cancer characterized by chromosomal translocations generating fusions of the EWSR1 gene with ETS transcription factors (in…”
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Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patients by Sannino, Giuseppina, Marchetto, Aruna, Ranft, Andreas, Jabar, Susanne, Zacherl, Constanze, Alba-Rubio, Rebeca, Stein, Stefanie, Wehweck, Fabienne S., Kiran, Merve M., Hölting, Tilman L.B., Musa, Julian, Romero-Pérez, Laura, Cidre-Aranaz, Florencia, Knott, Maximilian M.L., Li, Jing, Jürgens, Heribert, Sastre, Ana, Alonso, Javier, Da Silveira, Willian, Hardiman, Gary, Gerke, Julia S., Orth, Martin F., Hartmann, Wolfgang, Kirchner, Thomas, Ohmura, Shunya, Dirksen, Uta, Grünewald, Thomas G.P.

“…Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This is in part…”
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Systematic identification of cancer-specific MHC-binding peptides with RAVEN by Baldauf, Michaela C., Gerke, Julia S., Kirschner, Andreas, Blaeschke, Franziska, Effenberger, Manuel, Schober, Kilian, Rubio, Rebeca Alba, Kanaseki, Takayuki, Kiran, Merve M., Dallmayer, Marlene, Musa, Julian, Akpolat, Nurset, Akatli, Ayse N., Rosman, Fernando C., Özen, Özlem, Sugita, Shintaro, Hasegawa, Tadashi, Sugimura, Haruhiko, Baumhoer, Daniel, Knott, Maximilian M. L., Sannino, Giuseppina, Marchetto, Aruna, Li, Jing, Busch, Dirk H., Feuchtinger, Tobias, Ohmura, Shunya, Orth, Martin F., Thiel, Uwe, Kirchner, Thomas, Grünewald, Thomas G. P.

“…Immunotherapy can revolutionize anti-cancer therapy if specific targets are available. Immunogenic peptides encoded by cancer-specific genes (CSGs) may enable…”
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Lysosome-associated membrane glycoprotein 1 predicts fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens by Kirschner, Andreas, Thiede, Melanie, Blaeschke, Franziska, Richter, Günther H S, Gerke, Julia S, Baldauf, Michaela C, Grünewald, Thomas G P, Busch, Dirk H, Burdach, Stefan, Thiel, Uwe

“…Autologous as well as allogeneic CD8+ T cells transduced with tumor antigen specific T cell receptors (TCR) may cause significant tumor lysis upon adoptive…”
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Gene expression and immunohistochemical analyses identify SOX2 as major risk factor for overall survival and relapse in Ewing sarcoma patientsResearch in context by Giuseppina Sannino, Aruna Marchetto, Andreas Ranft, Susanne Jabar, Constanze Zacherl, Rebeca Alba-Rubio, Stefanie Stein, Fabienne S. Wehweck, Merve M. Kiran, Tilman L.B. Hölting, Julian Musa, Laura Romero-Pérez, Florencia Cidre-Aranaz, Maximilian M.L. Knott, Jing Li, Heribert Jürgens, Ana Sastre, Javier Alonso, Willian Da Silveira, Gary Hardiman, Julia S. Gerke, Martin F. Orth, Wolfgang Hartmann, Thomas Kirchner, Shunya Ohmura, Uta Dirksen, Thomas G.P. Grünewald

“…Background: Up to 30–40% of Ewing sarcoma (EwS) patients with non-metastatic disease develop local or metastatic relapse within a time span of 2–10 years. This…”
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