Search Results - "Gerkau, Niklas J"

Cotransporter-mediated water transport underlying cerebrospinal fluid formation by Steffensen, Annette B., Oernbo, Eva K., Stoica, Anca, Gerkau, Niklas J., Barbuskaite, Dagne, Tritsaris, Katerina, Rose, Christine R., MacAulay, Nanna

“…Cerebrospinal fluid (CSF) production occurs at a rate of 500 ml per day in the adult human. Conventional osmotic forces do not suffice to support such…”
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Epithelial Sodium Channel Regulates Adult Neural Stem Cell Proliferation in a Flow-Dependent Manner by Petrik, David, Myoga, Michael H., Grade, Sofia, Gerkau, Niklas J., Pusch, Melanie, Rose, Christine R., Grothe, Benedikt, Götz, Magdalena

“…One hallmark of adult neurogenesis is its adaptability to environmental influences. Here, we uncovered the epithelial sodium channel (ENaC) as a key regulator…”
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Glutamate transporter‐associated anion channels adjust intracellular chloride concentrations during glial maturation by Untiet, Verena, Kovermann, Peter, Gerkau, Niklas J., Gensch, Thomas, Rose, Christine R., Fahlke, Christoph

“…Astrocytic volume regulation and neurotransmitter uptake are critically dependent on the intracellular anion concentration, but little is known about the…”
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Changes in Astroglial K + upon Brief Periods of Energy Deprivation in the Mouse Neocortex by Eitelmann, Sara, Stephan, Jonathan, Everaerts, Katharina, Durry, Simone, Pape, Nils, Gerkau, Niklas J, Rose, Christine R

“…Malfunction of astrocytic K regulation contributes to the breakdown of extracellular K homeostasis during ischemia and spreading depolarization events…”
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Imaging of Local and Global Sodium Signals in Astrocytes by Gerkau, Niklas J, Kafitz, Karl W, Rose, Christine R

“…The use of fluorescent chemical indicator dyes enables the dynamic and quantitative imaging of intracellular sodium concentrations and activity-related sodium…”
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Roles of astrocytic Na+,K+-ATPase and glycogenolysis for K+ homeostasis in mammalian brain by Hertz, Leif, Gerkau, Niklas J., Xu, Junnan, Durry, Simone, Song, Dan, Rose, Christine R., Peng, Liang

“…Neuronal excitation increases extracellular K+ concentration ([K+]o) in vivo and in incubated brain tissue by stimulation of postsynaptic glutamatergic…”
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Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus by Barbuskaite, Dagne, Oernbo, Eva K, Wardman, Jonathan H, Toft-Bertelsen, Trine L, Conti, Eller, Andreassen, Saren N, Gerkau, Niklas J, Rose, Christine R, MacAulay, Nanna

“…Abstract Background Elevated intracranial pressure (ICP) is observed in many neurological pathologies, e.g. hydrocephalus and stroke. This condition is…”
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Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure by Oernbo, Eva K, Steffensen, Annette B, Razzaghi Khamesi, Pooya, Toft-Bertelsen, Trine L, Barbuskaite, Dagne, Vilhardt, Frederik, Gerkau, Niklas J, Tritsaris, Katerina, Simonsen, Anja H, Lolansen, Sara D, Andreassen, Saren N, Hasselbalch, Steen G, Zeuthen, Thomas, Rose, Christine R, Kurtcuoglu, Vartan, MacAulay, Nanna

“…Abstract Background Disturbances in the brain fluid balance can lead to life-threatening elevation in the intracranial pressure (ICP), which represents a vast…”
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Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences by Ziemens, Daniel, Oschmann, Franziska, Gerkau, Niklas J, Rose, Christine R

“…Activity-related sodium transients induced by glutamate uptake represent a special form of astrocyte excitability. Astrocytes of the neocortex, as opposed to…”
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Reverse NCX Attenuates Cellular Sodium Loading in Metabolically Compromised Cortex by Gerkau, Niklas J, Rakers, Cordula, Durry, Simone, Petzold, Gabor C, Rose, Christine R

“…Abstract In core regions of ischemic stroke, disruption of blood flow causes breakdown of ionic gradients and, ultimately, calcium overload and cell death. In…”
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Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes by Gerkau, Niklas J., Rakers, Cordula, Petzold, Gabor C., Rose, Christine R.

“…The maintenance of a low intracellular sodium concentration by the Na+/K+‐ATPase (NKA) is critical for brain function. In both neurons and glial cells, NKA…”
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Rapid Fluorescence Lifetime Imaging Reveals That TRPV4 Channels Promote Dysregulation of Neuronal Na + in Ischemia by Meyer, Jan, Gerkau, Niklas J, Kafitz, Karl W, Patting, Matthias, Jolmes, Fabian, Henneberger, Christian, Rose, Christine R

“…Fluorescence imaging is an indispensable method for analysis of diverse cellular and molecular processes, enabling, for example, detection of ions, second…”
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Relation between activity‐induced intracellular sodium transients and ATP dynamics in mouse hippocampal neurons by Gerkau, Niklas J., Lerchundi, Rodrigo, Nelson, Joel S. E., Lantermann, Marina, Meyer, Jan, Hirrlinger, Johannes, Rose, Christine R.

“…Key points Employing quantitative Na+‐imaging and Förster resonance energy transfer‐based imaging with ATeam1.03YEMK (ATeam), we studied the relation between…”
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Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet by Langer, Julia, Gerkau, Niklas J., Derouiche, Amin, Kleinhans, Christian, Moshrefi‐Ravasdjani, Behrouz, Fredrich, Michaela, Kafitz, Karl W., Seifert, Gerald, Steinhäuser, Christian, Rose, Christine R.

“…Perivascular endfeet of astrocytes are highly polarized compartments that ensheath blood vessels and contribute to the blood–brain barrier. They experience…”
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Two-Photon Na + Imaging Reports Somatically Evoked Action Potentials in Rat Olfactory Bulb Mitral and Granule Cell Neurites by Ona-Jodar, Tiffany, Gerkau, Niklas J, Sara Aghvami, S, Rose, Christine R, Egger, Veronica

“…Dendrodendritic synaptic interactions are a hallmark of neuronal processing in the vertebrate olfactory bulb. Many classes of olfactory bulb neurons including…”
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Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation: EAAT Anion Channels Determine [Cl - ] in Glial Cells by Untiet, Verena, Kovermann, Peter, Gerkau, Niklas J., Gensch, Thomas, Rose, Christine R., Fahlke, Christoph

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Roles of astrocytic Na super(+),K super(+)-ATPase and glycogenolysis for K super(+) homeostasis in mammalian brain by Hertz, Leif, Gerkau, Niklas J, Xu, Junnan, Durry, Simone, Song, Dan, Rose, Christine R, Peng, Liang

“…Neuronal excitation increases extracellular K super(+) concentration ([K super(+)] sub(o)) in vivo and in incubated brain tissue by stimulation of postsynaptic…”
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Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet: Sodium Signals in Astrocyte Endfeet by Langer, Julia, Gerkau, Niklas J., Derouiche, Amin, Kleinhans, Christian, Moshrefi-Ravasdjani, Behrouz, Fredrich, Michaela, Kafitz, Karl W., Seifert, Gerald, Steinhäuser, Christian, Rose, Christine R.

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