Search Results - "Gerich, Mark"

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor by Alexeev, Erica E., Lanis, Jordi M., Kao, Daniel J., Campbell, Eric L., Kelly, Caleb J., Battista, Kayla D., Gerich, Mark E., Jenkins, Brittany R., Walk, Seth T., Kominsky, Douglas J., Colgan, Sean P.

“…Interactions between the gut microbiota and the host are important for health, where dysbiosis has emerged as a likely component of mucosal disease. The…”
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Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome by Neudecker, Viola, Haneklaus, Moritz, Jensen, Owen, Khailova, Ludmila, Masterson, Joanne C, Tye, Hazel, Biette, Kathryn, Jedlicka, Paul, Brodsky, Kelley S, Gerich, Mark E, Mack, Matthias, Robertson, Avril A B, Cooper, Matthew A, Furuta, Glenn T, Dinarello, Charles A, O'Neill, Luke A, Eltzschig, Holger K, Masters, Seth L, McNamee, Eóin N

“…MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but how miRNA circuits orchestrate aberrant intestinal inflammation during…”
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Creatine Transporter, Reduced in Colon Tissues From Patients With Inflammatory Bowel Diseases, Regulates Energy Balance in Intestinal Epithelial Cells, Epithelial Integrity, and Barrier Function by Hall, Caroline H.T., Lee, J. Scott, Murphy, Emily M., Gerich, Mark E., Dran, Rachael, Glover, Louis E., Abdulla, Zuhair I., Skelton, Matthew R., Colgan, Sean P.

“…Patients with inflammatory bowel diseases (IBDs) have intestinal barrier dysfunction. Creatine regulates energy distribution within cells and reduces the…”
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Delays Related to Prior Authorization in Inflammatory Bowel Disease by Constant, Brad D, de Zoeten, Edwin F, Stahl, Marisa G, Vajravelu, Ravy K, Lewis, James D, Fennimore, Blair, Gerich, Mark E, Scott, Frank I

“…Delays in advancing to biologic therapies are associated with adverse outcomes in inflammatory bowel disease (IBD). Insurer-mandated prior authorizations have…”
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Prospective Cohort Study to Investigate the Safety of Preoperative Tumor Necrosis Factor Inhibitor Exposure in Patients With Inflammatory Bowel Disease Undergoing Intra-abdominal Surgery by Cohen, Benjamin L., Fleshner, Phillip, Kane, Sunanda V., Herfarth, Hans H., Palekar, Nicole, Farraye, Francis A., Leighton, Jonathan A., Katz, Jeffry A., Cohen, Russell D., Gerich, Mark E., Cross, Raymond K., Higgins, Peter D.R., Tinsley, Andrew, Glover, Sarah, Siegel, Corey A., Bohl, Jaime L., Iskandar, Heba, Ji, Jiayi, Hu, Liangyuan, Sands, Bruce E.

“…Whether preoperative treatment of inflammatory bowel disease (IBD) with tumor necrosis factor inhibitors (TNFis) increases the risk of postoperative infectious…”
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Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition by Robinson, Andreas, Keely, Simon, Karhausen, Jörn, Gerich, Mark E, Furuta, Glenn T, Colgan, Sean P

“…Background & Aims: A number of recent studies have implicated tissue hypoxia in both acute and chronic inflammatory diseases, particularly as they relate to…”
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Medical marijuana for digestive disorders: high time to prescribe? by Gerich, Mark E, Isfort, Robert W, Brimhall, Bryan, Siegel, Corey A

“…The use of recreational and medical marijuana is increasingly accepted by the general public in the United States. Along with growing interest in marijuana use…”
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Multi 'Omics Analysis of Intestinal Tissue in Ankylosing Spondylitis Identifies Alterations in the Tryptophan Metabolism Pathway by Berlinberg, Adam J, Regner, Emilie H, Stahly, Andrew, Brar, Ana, Reisz, Julie A, Gerich, Mark E, Fennimore, Blair P, Scott, Frank I, Freeman, Alison E, Kuhn, Kristine A

“…Intestinal microbial dysbiosis, intestinal inflammation, and Th17 immunity are all linked to the pathophysiology of spondyloarthritis (SpA); however, the…”
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Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review by Leinwand, Kristina L, Gerich, Mark E, Hoffenberg, Edward J, Collins, Colm B

“…Inflammatory bowel disease (IBD) is a lifelong disease of the gastrointestinal tract whose annual incidence and prevalence is on the rise. Current…”
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HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis by Czopik, Agnieszka K., McNamee, Eóin N., Vaughn, Victoria, Huang, Xiangsheng, Bang, In Hyuk, Clark, Trent, Wang, Yanyu, Ruan, Wei, Nguyen, Tom, Masterson, Joanne C., Tak, Eunyoung, Frank, Sandra, Collins, Colm B., Li, Howard, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Gerich, Mark E., Furuta, Glenn T., Yuan, Xiaoyi, Sood, Anil K., de Zoeten, Edwin F., Eltzschig, Holger K.

“…Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel…”
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Functional intraepithelial lymphocyte changes in inflammatory bowel disease and spondyloarthritis have disease specific correlations with intestinal microbiota by Regner, Emilie H, Ohri, Neha, Stahly, Andrew, Gerich, Mark E, Fennimore, Blair P, Ir, Diana, Jubair, Widian K, Görg, Carsten, Siebert, Janet, Robertson, Charles E, Caplan, Liron, Frank, Daniel N, Kuhn, Kristine A

“…Dysbiosis occurs in spondyloarthritis (SpA) and inflammatory bowel disease (IBD), which is subdivided into Crohn's disease (CD) and ulcerative colitis (UC)…”
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Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn’s Disease by Scott, Frank I., Hans, Amneet K., Gerich, Mark E., Fennimore, Blair, Mamtani, Ronac, Vajravelu, Ravy K., Lewis, James D.

“…Ustekinumab is a monoclonal antibody against interleukin 12 and interleukin 23 that has been approved by the Food and Drug Administration for treatment of…”
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S897 Ustekinumab Versus Tofacitinib as Second-Line Therapy for Ulcerative Colitis: A Retrospective, Observational Study by Galatowitsch, John, Haydek, John P., Ahmed, Waseem, Fennimore, Blair, Cheng, Debbie, Steiner, Calen A., Click, Benjamin, Gerich, Mark E., Oonk, Alexis, Scott, Frank I.

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Circulating mature granzyme B+ T cells distinguish Crohn's disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn's disease by Lefferts, Adam R, Regner, Emilie H, Stahly, Andrew, O'Rourke, Becky, Gerich, Mark E, Fennimore, Blair P, Scott, Frank I, Freeman, Alison E, Jones, Ken, Kuhn, Kristine A

“…Axial spondyloarthritis (axSpA) has strong connections with intestinal inflammation as occurs in Crohn's disease (CD). However, the immunologic mechanisms that…”
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Towards personalized care in IBD by Gerich, Mark E., McGovern, Dermot P. B.

“…Key Points Basic science advances herald an era in which IBD will be subcategorized on the basis of the involvement of specific molecular pathways Knowledge of…”
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Fecal microbiota transplant in patients with Clostridium difficile infection: A systematic review by Chapman, Brandon C, Moore, Hunter B, Overbey, Douglas M, Morton, Alex P, Harnke, Ben, Gerich, Mark E, Vogel, Jon D

“…Fecal microbiota transplantation (FMT) restores a diverse bacterial profile to the gastrointestinal tract and may effectively treat patients with Clostridium…”
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Muc5ac Expression Protects the Colonic Barrier in Experimental Colitis by Olli, Kristine E, Rapp, Caroline, O’Connell, Lauren, Collins, Colm B, McNamee, Eoin N, Jensen, Owen, Jedlicka, Paul, Allison, Kristen C, Goldberg, Matthew S, Gerich, Mark E, Frank, Daniel N, Ir, Diana, Robertson, Charles E, Evans, Christopher M, Aherne, Carol M

“…Recent studies highlight the importance of mucins, in particular Muc2, in intestinal homeostasis. Our functional study demonstrates that an alternative…”
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Mucosal acidosis elicits a unique molecular signature in epithelia and intestinal tissue mediated by GPR31-induced CREB phosphorylation by Cartwright, Ian M., Dowdell, Alexander S., Lanis, Jordi M., Brink, Kathryn R., Mu, Andrew, Kostelecky, Rachael E., Schaefer, Rachel E. M., Welch, Nichole, Onyiah, Joseph C., Hall, Caroline H. T., Gerich, Mark E., Tabor, Jeffrey J., Colgan, Sean P.

“…Metabolic changes associated with tissue inflammation result in significant extracellular acidosis (EA). Within mucosal tissues, intestinal epithelial cells…”
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High Hope for Medical Marijuana in Digestive Disorders by Isfort, Robert W, Gerich, Mark E

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First Reported Case of Pembrolizumab-Induced Immune Mediated Hemorrhagic Gastritis by cinnor, Birtukan, Crossman, Hayley, Kaplan, Jeffrey, Mittal, Chetan, Gerich, Mark E, Kao, Daniel J

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