Search Results - "Gerhold, L"

A hybrid gene selection approach to create the S1500+ targeted gene sets for use in high-throughput transcriptomics by Mav, Deepak, Shah, Ruchir R, Howard, Brian E, Auerbach, Scott S, Bushel, Pierre R, Collins, Jennifer B, Gerhold, David L, Judson, Richard S, Karmaus, Agnes L, Maull, Elizabeth A, Mendrick, Donna L, Merrick, B Alex, Sipes, Nisha S, Svoboda, Daniel, Paules, Richard S

“…Changes in gene expression can help reveal the mechanisms of disease processes and the mode of action for toxicities and adverse effects on cellular responses…”
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Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury by Holder, Daniel, Aslamkhan, Amy G, Shughrue, Paul, Shi, Shu, Muniappa, Nagaraja, Villarreal, Stephanie, Bailey, Wendy, Yu, Yan, Thudium, Douglas, Ozer, Josef S, Figueroa, David J, Clouse, Holly, Troth, Sean P, Jin, Hong, Su, Ming, Sistare, Frank D, Gerhold, David L, Seng, John

“…Exposure of rats to kidney toxicants reduces levels of urinary trefoil factor 3 (TFF3) and increases levels of urinary albumin. Whereas urinary albumin…”
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3D-Suspension culture platform for high throughput screening of neurotoxic chemicals using LUHMES dopaminergic neurons by Tong, Zhi-Bin, Huang, Ruili, Braisted, John, Chu, Pei-Hsuan, Simeonov, Anton, Gerhold, David L.

“…•A method is described for culturing LUHMES dopaminergic neuronal cells in 3D spheroids in 1536-well format suitable for high-throughput…”
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Familial-combined hyperlipidaemia in very young myocardial infarction survivors (≤40 years of age) by Wiesbauer, Franz, Blessberger, Hermann, Azar, Danyel, Goliasch, Georg, Wagner, Oswald, Gerhold, Lukas, Huber, Kurt, Widhalm, Kurt, Abdolvahab, Farshid, Sodeck, Gottfried, Maurer, Gerald, Schillinger, Martin

“…Aims Myocardial infarction (MI) in very young individuals is a rare disease associated with an unfavourable prognosis. Familial-combined hyperlipidaemia (FCHL)…”
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Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases by Wang, H, Sun, H, Della Penna, K, Benz, R.J, Xu, J, Gerhold, D.L, Holder, D.J, Koblan, K.S

“…Neuropathic pain is induced by injury or disease of the nervous system. Studies aimed at understanding the molecular pathophysiology of neuropathic pain have…”
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Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing Consortium by Dieterle, Frank, Sistare, Frank, Goodsaid, Federico, Papaluca, Marisa, Ozer, Josef S, Webb, Craig P, Baer, William, Senagore, Anthony, Schipper, Matthew J, Vonderscher, Jacky, Sultana, Stefan, Gerhold, David L, Phillips, Jonathan A, Maurer, Gérard, Carl, Kevin, Laurie, David, Harpur, Ernie, Sonee, Manisha, Ennulat, Daniela, Holder, Dan, Andrews-Cleavenger, Dina, Gu, Yi-Zhong, Thompson, Karol L, Goering, Peter L, Vidal, Jean-Marc, Abadie, Eric, Maciulaitis, Romaldas, Jacobson-Kram, David, Defelice, Albert F, Hausner, Elizabeth A, Blank, Melanie, Thompson, Aliza, Harlow, Patricia, Throckmorton, Douglas, Xiao, Shen, Xu, Nancy, Taylor, William, Vamvakas, Spiros, Flamion, Bruno, Lima, Beatriz Silva, Kasper, Peter, Pasanen, Markku, Prasad, Krishna, Troth, Sean, Bounous, Denise, Robinson-Gravatt, Denise, Betton, Graham, Davis, Myrtle A, Akunda, Jackie, McDuffie, James Eric, Suter, Laura, Obert, Leslie, Guffroy, Magalie, Pinches, Mark, Jayadev, Supriya, Blomme, Eric A, Beushausen, Sven A, Barlow, Valérie G, Collins, Nathaniel, Waring, Jeff, Honor, David, Snook, Sandra, Lee, Jinhe, Rossi, Phil, Walker, Elizabeth, Mattes, William

“…The first formal qualification of safety biomarkers for regulatory decision making marks a milestone in the application of biomarkers to drug development…”
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Better therapeutics through microarrays by Gerhold, David L, Jensen, Roderick V, Gullans, Steven R

“…DNA microarrays are an integral part of the process for therapeutic discovery, optimization and clinical validation. At an early stage, investigators use…”
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Stem Cell-Derived Endothelial Cell Model that Responds to Tobacco Smoke Like Primary Endothelial Cells by Chu, Pei-Hsuan, Chen, Guibin, Kuo, David, Braisted, John, Huang, Ruili, Wang, Yuhong, Simeonov, Anton, Boehm, Manfred, Gerhold, David L

“…To clarify how smoking leads to heart attack and stroke, we developed an endothelial cell model (iECs) generated from human induced Pluripotent Stem Cells…”
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Austria's path toward nationwide electronic health records by Dorda, W, Duftschmid, G, Gerhold, L, Gall, W, Gambal, J

“…This article discusses current planning activities in Austria after legislation has been passed to introduce the electronic health record (EHR). After…”
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Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats by Glaab, Warren E, Holder, Daniel, He, Yudong D, Bailey, Wendy J, Gerhold, David L, Beare, Carolann, Erdos, Zoltan, Lane, Pamela, Michna, Laura, Muniappa, Nagaraja, Lawrence, Jeffrey W, Tanis, Keith Q, Sina, Joseph F, Skopek, Thomas R, Sistare, Frank D

“…Abstract A new safety testing paradigm that relies on gene expression biomarker panels was developed to easily and quickly identify drug-induced injuries…”
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Estradiol Attenuates Programmed Cell Death after Stroke-Like Injury by Rau, Shane W, Dubal, Dena B, Bottner, Martina, Gerhold, Lynnette M, Wise, Phyllis M

“…Estradiol is a known neurotrophic and neuroprotective factor. Our previous work demonstrated that replacement with physiological concentrations of estradiol…”
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A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function by Gerhold, David L, Ozer, Josef S, Dieterle, Frank, Troth, Sean, Perentes, Elias, Cordier, André, Verdes, Pablo, Staedtler, Frank, Mahl, Andreas, Grenet, Olivier, Roth, Daniel R, Wahl, Daniel, Legay, François, Holder, Daniel, Erdos, Zoltan, Vlasakova, Katerina, Jin, Hong, Yu, Yan, Muniappa, Nagaraja, Forest, Tom, Clouse, Holly K, Reynolds, Spencer, Bailey, Wendy J, Thudium, Douglas T, Topper, Michael J, Skopek, Thomas R, Sina, Joseph F, Glaab, Warren E, Vonderscher, Jacky, Maurer, Gérard, Chibout, Salah-Dine, Sistare, Frank D

“…A panel of urinary biomarkers enables the progression of renal injury and subsequent repair and recovery to be monitored after exposure of rats to either…”
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Diagnosis of drug-induced renal tubular toxicity using global gene expression profiles by Jiang, Ying, Gerhold, David L, Holder, Daniel J, Figueroa, David J, Bailey, Wendy J, Guan, Ping, Skopek, Thomas R, Sistare, Frank D, Sina, Joseph F

“…Toxicogenomics can measure the expression of thousands of genes to identify changes associated with drug induced toxicities. It is expected that toxicogenomics…”
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The Toxmatrix: Chemo-Genomic Profiling Identifies Interactions That Reveal Mechanisms of Toxicity by Tong, Zhi-Bin, Huang, Ruili, Wang, Yuhong, Klumpp-Thomas, Carleen A, Braisted, John C, Itkin, Zina, Shinn, Paul, Xia, Menghang, Simeonov, Anton, Gerhold, David L

“…A chemical genomics “Toxmatrix” method was developed to elucidate mechanisms of cytotoxicity using neuronal models. Quantitative high-throughput screening…”
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Vasoactive intestinal peptide fibers innervate neuroendocrine dopaminergic neurons by Gerhold, Lynnette M, Horvath, Tamas L, Freeman, Marc E

“…Hypothalamic neuroendocrine dopaminergic neurons exhibit a diurnal rhythm. Higher level input to these neurons has not been described. In the present study, we…”
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Gene Expression Profile of Adipocyte Differentiation and Its Regulation by Peroxisome Proliferator-Activated Receptor-γ Agonists by Gerhold, David L, Liu, Franklin, Jiang, Guoqiang, Li, Zhihua, Xu, Jian, Lu, Meiqing, Sachs, Jeffrey R, Bagchi, Ansuman, Fridman, Arthur, Holder, Daniel J, Doebber, Thomas W, Berger, Joel, Elbrecht, Alex, Moller, David E, Zhang, Bei B

“…PPARγ is an adipocyte-specific nuclear hormone receptor. Agonists of PPARγ, such as thiazolidinediones (TZDs), promote adipocyte differentiation and have…”
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Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry by Sun, Hong, Xu, Jian, Della Penna, Kimberly B, Benz, Robert J, Kinose, Fumi, Holder, Daniel J, Koblan, Kenneth S, Gerhold, David L, Wang, Hao

“…Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit…”
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Antagonism of vasoactive intestinal peptide mRNA in the suprachiasmatic nucleus disrupts the rhythm of FRAs expression in neuroendocrine dopaminergic neurons by Gerhold, Lynnette M., Sellix, Michael T., Freeman, Marc E.

“…This study was designed to determine whether there is a functional relationship between cfos expression in vasoactive intestinal peptide (VIP) ‐containing…”
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Requirements for the use of impact-based forecasts and warnings by road maintenance services in Germany by Schmidt, Jasmina, Tietze, Nikola, Gerhold, Lars, Kox, Thomas

“…Impact-based forecasts and warnings (IBFs) are seen as important drivers for adequate anticipation and assessment of potential threats to public safety as they…”
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Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists by Gerhold, David L, Liu, Franklin, Jiang, Guoqiang, Li, Zhihua, Xu, Jian, Lu, Meiqing, Sachs, Jeffrey R, Bagchi, Ansuman, Fridman, Arthur, Holder, Daniel J, Doebber, Thomas W, Berger, Joel, Elbrecht, Alex, Moller, David E, Zhang, Bei B

“…PPAR gamma is an adipocyte-specific nuclear hormone receptor. Agonists of PPAR gamma, such as thiazolidinediones (TZDs), promote adipocyte differentiation and…”
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