A double whammy for KEAP1

In this issue of Cell Chemical Biology, Lu et al. report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to previously reported monovalent KEAP1 inhibitors. biKEAP1suppresses acute inflammation in animal models.

Bibliographic Details

Published in:	Cell chemical biology Vol. 31; no. 6; p. 1047
Main Authors:	Gerhartz, Jan, Nowak, Radosław P
Format:	Journal Article
Language:	English
Published:	United States 20-06-2024
Subjects:	Animals Humans Inflammation - drug therapy Inflammation - metabolism Kelch-Like ECH-Associated Protein 1 - antagonists & inhibitors Kelch-Like ECH-Associated Protein 1 - metabolism Mice NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - metabolism
Online Access:	Get more information
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