Search Results - "Gerhardt, Lara"

Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy by Krishnamoorthy, Mithunah, Gerhardt, Lara, Maleki Vareki, Saman

“…The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells…”
Get full text

587 Inducing mismatch repair deficiency in combination with anti-CTLA4 therapy is highly effective against non-immunogenic neuroblastoma tumors by El-Hajjar, Mikal, Gerhardt, Lara, Krishnamoorthy, Mithunah, Figueredo, Rene, Zheng, Xiufen, Koropatnick, James, Maleki, Saman

“…BackgroundDespite rigorous multimodal therapy, recurrence is common among high-risk neuroblastoma patients. Neuroblastoma is a poorly immunogenic tumor with…”
Get full text

IL-12 and IL-27 Promote CD39 Expression on CD8+ T Cells and Differentially Regulate the CD39+CD8+ T Cell Phenotype by Gerhardt, Lara, Hong, Megan M Y, Yousefi, Yeganeh, Figueredo, Rene, Maleki Vareki, Saman

“…Tumor-specific CD8+ T cells are critical components of antitumor immunity; however, factors that modulate their phenotype and function have not been completely…”
Get full text

1028 IL-12 and IL-27 upregulate CD39 expression on CD8+ T-cells and differentially affect CD39+CD8+ T-cell effector function by Gerhardt, Lara, Figueredo, Rene, Maleki, Saman

“…BackgroundTumor-specific CD8+ T-cells play a critical role in tumor control, as demonstrated by the success of immune checkpoint inhibitors and adoptive cell…”
Get full text

Inducing mismatch repair deficiency sensitizes immune-cold neuroblastoma to anti-CTLA4 and generates broad anti-tumor immune memory by El-Hajjar, Mikal, Gerhardt, Lara, Hong, Megan M Y, Krishnamoorthy, Mithunah, Figueredo, Rene, Zheng, Xiufen, Koropatnick, James, Maleki Vareki, Saman

“…Immune checkpoint blockade can induce potent and durable responses in patients with highly immunogenic mismatch repair-deficient tumors; however, these drugs…”
Get full text