Search Results - "Gerhard, Markus"

Identification and characterization of nucleobase-modified aptamers by click-SELEX by Pfeiffer, Franziska, Tolle, Fabian, Rosenthal, Malte, Brändle, Gerhard Markus, Ewers, Jörg, Mayer, Günter

“…This protocol describes an approach to generate chemically modified aptamers using CuAAC click chemistry. Such aptamers possess extended interaction properties…”
Get full text

The Helicobacter pylori Type IV Secretion System Encoded by the cag Pathogenicity Island: Architecture, Function, and Signaling by Backert, Steffen, Haas, Rainer, Gerhard, Markus, Naumann, Michael

“…Various gram-negative pathogens express type IV secretion systems (T4SSs) which translocate bacterial virulence factors into host target cells to hijack…”
Get more information

Effect of Helicobacter pylori on gastrointestinal microbiota: a population-based study in Linqu, a high-risk area of gastric cancer by Guo, Yang, Zhang, Yang, Gerhard, Markus, Gao, Juan-Juan, Mejias-Luque, Raquel, Zhang, Lian, Vieth, Michael, Ma, Jun-Ling, Bajbouj, Monther, Suchanek, Stepan, Liu, Wei-Dong, Ulm, Kurt, Quante, Michael, Li, Zhe-Xuan, Zhou, Tong, Schmid, Roland, Classen, Meinhard, Li, Wen-Qing, You, Wei-Cheng, Pan, Kai-Feng

“…Gastrointestinal microbiota may be involved in associated gastric cancer development. The aim of this study was to explore the possible microbial mechanisms in…”
Get more information

PLP‐dependent enzymes as entry and exit gates of sphingolipid metabolism by Bourquin, Florence, Capitani, Guido, Grütter, Markus Gerhard

“…Sphingolipids are membrane constituents as well as signaling molecules involved in many essential cellular processes. Serine palmitoyltransferase (SPT) and…”
Get full text

JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter pylori Infection and Contributes to Immune Escape and Gastric Carcinogenesis by Li, Xue, Pan, Kaifeng, Vieth, Michael, Gerhard, Markus, Li, Wenqing, Mejiías-Luque, Raquel

“…infection induces a number of pro-inflammatory signaling pathways contributing to gastric inflammation and carcinogenesis and has been identified as a major…”
Get full text

Helicobacter pylori vaccination:Is there a path to protection? by Anderl, Florian, Gerhard, Markus

“…Helicobacter pylori(H.pylori)is a pathogenic,extracellular bacterium that colonizes the stomach in approximately 50%of the world population.It strongly…”
Get full text

Mitochondrial function controls intestinal epithelial stemness and proliferation by Berger, Emanuel, Rath, Eva, Yuan, Detian, Waldschmitt, Nadine, Khaloian, Sevana, Allgäuer, Michael, Staszewski, Ori, Lobner, Elena M., Schöttl, Theresa, Giesbertz, Pieter, Coleman, Olivia I., Prinz, Marco, Weber, Achim, Gerhard, Markus, Klingenspor, Martin, Janssen, Klaus-Peter, Heikenwalder, Mathias, Haller, Dirk

“…Control of intestinal epithelial stemness is crucial for tissue homeostasis. Disturbances in epithelial function are implicated in inflammatory and neoplastic…”
Get full text

Helicobacter pylori γ-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance by Oertli, Mathias, Noben, Manuel, Engler, Daniela B., Semper, Raphaela P., Reuter, Sebastian, Maxeiner, Joachim, Gerhard, Markus, Taube, Christian, Müller, Anne

“…Infection with the gastric bacterial pathogen Helicobacter pylori is typically contracted in early childhood and often persists for decades. The…”
Get full text

Effects of Helicobacter pylori infection on intestinal microbiota, immunity and colorectal cancer risk by Engelsberger, Veronika, Gerhard, Markus, Mejías-Luque, Raquel

“…Infecting about half of the world´s population, is one of the most prevalent bacterial infections worldwide and the strongest known risk factor for gastric…”
Get full text

Effects of Helicobacter pylori adhesin HopQ binding to CEACAM receptors in the human stomach by Nguyen, Quynh Anh, Schmitt, Leonard, Mejías-Luque, Raquel, Gerhard, Markus

“…has developed several strategies using its diverse virulence factors to trigger and, at the same time, limit the host's inflammatory responses in order to…”
Get full text

Helicobacter pylori cytotoxin-associated gene A impairs human dendritic cell maturation and function through IL-10-mediated activation of STAT3 by Kaebisch, Romy, Mejías-Luque, Raquel, Prinz, Christian, Gerhard, Markus

“…Helicobacter pylori infection induces chronic gastric inflammation that can progress to cancer. In this process, the virulence factor cytotoxin-associated gene…”
Get full text

Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10 by Engler, Daniela B., Reuter, Sebastian, van Wijck, Yolanda, Urban, Sabine, Kyburz, Andreas, Maxeiner, Joachim, Martin, Helen, Yogev, Nir, Waisman, Ari, Gerhard, Markus, Cover, Timothy L., Taube, Christian, Müller, Anne

“…The prevalence of allergic asthma and other atopic diseases has reached epidemic proportions in large parts of the developed world. The gradual loss of the…”
Get full text

Dynamics of spike-and nucleocapsid specific immunity during long-term follow-up and vaccination of SARS-CoV-2 convalescents by Koerber, Nina, Priller, Alina, Yazici, Sarah, Bauer, Tanja, Cheng, Cho-Chin, Mijočević, Hrvoje, Wintersteller, Hannah, Jeske, Samuel, Vogel, Emanuel, Feuerherd, Martin, Tinnefeld, Kathrin, Winter, Christof, Ruland, Jürgen, Gerhard, Markus, Haller, Bernhard, Christa, Catharina, Zelger, Otto, Roggendorf, Hedwig, Halle, Martin, Erber, Johanna, Lingor, Paul, Keppler, Oliver, Zehn, Dietmar, Protzer, Ulrike, Knolle, Percy A.

“…Anti-viral immunity continuously declines over time after SARS-CoV-2 infection. Here, we characterize the dynamics of anti-viral immunity during long-term…”
Get full text

Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells by Toller, Isabella M, Neelsen, Kai J, Steger, Martin, Hartung, Mara L, Hottiger, Michael O, Stucki, Manuel, Kalali, Behnam, Gerhard, Markus, Sartori, Alessandro A, Lopes, Massimo, Müller, Anne

“…The bacterial pathogen Helicobacter pylori chronically infects the human gastric mucosa and is the leading risk factor for the development of gastric cancer…”
Get full text

H. pylori Virulence Factors: Influence on Immune System and Pathology by Gerhard, Markus, Javaheri, Anahita, Mejías-Luque, Raquel, Kalali, Behnam

“…Helicobacter pylori is the most widespread chronic bacterial agent in humans and is well recognized for its association with ulcer disease and gastric cancer,…”
Get full text

CMV seropositivity is a potential novel risk factor for severe COVID-19 in non-geriatric patients by Weber, Simone, Kehl, Victoria, Erber, Johanna, Wagner, Karolin I, Jetzlsperger, Ana-Marija, Burrell, Teresa, Schober, Kilian, Schommers, Philipp, Augustin, Max, Crowell, Claudia S, Gerhard, Markus, Winter, Christof, Moosmann, Andreas, Spinner, Christoph D, Protzer, Ulrike, Hoffmann, Dieter, D'Ippolito, Elvira, Busch, Dirk H

“…COVID-19 has so far affected more than 250 million individuals worldwide, causing more than 5 million deaths. Several risk factors for severe disease have been…”
Get full text

The stem cell factor SOX2 regulates the tumorigenic potential in human gastric cancer cells by Hütz, Katharina, Mejías-Luque, Raquel, Farsakova, Katarina, Ogris, Manfred, Krebs, Stefan, Anton, Martina, Vieth, Michael, Schüller, Ulrich, Schneider, Marlon R, Blum, Helmut, Wagner, Ernst, Jung, Andreas, Gerhard, Markus

“…Gastric cancer (GC) is still one of the most common causes of cancer-related death worldwide, which is mainly attributable to late diagnosis and poor treatment…”
Get full text

Association Between Gut Microbiota and Helicobacter pylori -Related Gastric Lesions in a High-Risk Population of Gastric Cancer by Gao, Juan-Juan, Zhang, Yang, Gerhard, Markus, Mejias-Luque, Raquel, Zhang, Lian, Vieth, Michael, Ma, Jun-Ling, Bajbouj, Monther, Suchanek, Stepan, Liu, Wei-Dong, Ulm, Kurt, Quante, Michael, Li, Zhe-Xuan, Zhou, Tong, Schmid, Roland, Classen, Meinhard, Li, Wen-Qing, You, Wei-Cheng, Pan, Kai-Feng

“…Eradication of has been found to be effective for gastric cancer prevention, but uncertainties remain about the possible adverse consequences such as the…”
Get full text

A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation by Schneider, Marlon R, Dahlhoff, Maik, Horst, David, Hirschi, Benjamin, Trülzsch, Konrad, Müller-Höcker, Josef, Vogelmann, Roger, Allgäuer, Michael, Gerhard, Markus, Steininger, Sylvia, Wolf, Eckhard, Kolligs, Frank T

“…E-cadherin is a major component of adherens junctions. Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed…”
Get full text

The Helicobacter pylori HopQ outermembrane protein inhibits immune cell activities by Gur, Chamutal, Maalouf, Naseem, Gerhard, Markus, Singer, Bernhard B., Emgård, Johanna, Temper, Violeta, Neuman, Tzahi, Mandelboim, Ofer, Bachrach, Gilad

“…We previously showed that the colorectal cancer colonizing bacterium Fusobacterium nucleatum protects tumors from immune cell attack via binding of the…”
Get full text