Search Results - "Gerhard, J."
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Varying label density allows artifact-free analysis of membrane-protein nanoclusters
Published in Nature methods (01-08-2016)“…PALM and STORM are powerful methods for studying membrane-protein clustering. However, fluorophore blinking can lead to miscounting artifacts. A new method…”
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With or without rafts? Alternative views on cell membranes
Published in BioEssays (01-02-2016)“…The fundamental mechanisms of protein and lipid organization at the plasma membrane have continued to engage researchers for decades. Among proposed models,…”
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Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome
Published in International journal of infectious diseases (01-11-2020)“…•Much of Covid-19 hyperinflammation is consistent with mast-cell-driven inflammation.•Prevalence of severe Covid-19 is similar to that of mast cell activation…”
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Microbial control of the dark end of the biological pump
Published in Nature geoscience (01-09-2013)“…The flux of carbon out of the ocean surface is not sufficient to meet the energy demands of microbes in the dark ocean. A review of the literature suggests…”
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Dissolved organic carbon leaching from plastics stimulates microbial activity in the ocean
Published in Nature communications (12-04-2018)“…Approximately 5.25 trillion plastic pieces are floating at the sea surface. The impact of plastic pollution on the lowest trophic levels of the food web,…”
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Events as Elements of Physical Observation: Experimental Evidence
Published in Entropy (Basel, Switzerland) (13-03-2024)“…It is argued that all physical knowledge ultimately stems from observation and that the simplest possible observation is that an event has happened at a…”
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7
TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity
Published in Nature (London) (18-02-2010)“…The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune responses. It is driven by specific T-cell antigen receptors (TCRs)…”
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Hijacking the Supplies: Metabolism as a Novel Facet of Virus-Host Interaction
Published in Frontiers in immunology (03-07-2019)“…Viral replication is a process that involves an extremely high turnover of cellular molecules. Since viruses depend on the host cell to obtain the…”
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The composition of bacterial communities associated with plastic biofilms differs between different polymers and stages of biofilm succession
Published in PloS one (05-06-2019)“…Once in the ocean, plastics are rapidly colonized by complex microbial communities. Factors affecting the development and composition of these communities are…”
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10
Single-molecule optical absorption imaging by nanomechanical photothermal sensing
Published in Proceedings of the National Academy of Sciences - PNAS (30-10-2018)“…Absorption microscopy is a promising alternative to fluorescence microscopy for single-molecule imaging. So far, molecular absorption has been probed optically…”
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The microbiome of coral surface mucus has a key role in mediating holobiont health and survival upon disturbance
Published in The ISME Journal (01-09-2016)“…Microbes are well-recognized members of the coral holobiont. However, little is known about the short-term dynamics of mucus-associated microbial communities…”
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12
A critical survey of methods to detect plasma membrane rafts
Published in Philosophical transactions of the Royal Society of London. Series B. Biological sciences (05-02-2013)“…The plasma membrane is still one of the enigmatic cellular structures. Although the microscopic structure is getting clearer, not much is known about the…”
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13
Monomeric TCRs drive T cell antigen recognition
Published in Nature immunology (01-05-2018)“…T cell antigen recognition requires T cell antigen receptors (TCRs) engaging MHC-embedded antigenic peptides (pMHCs) within the contact region of a T cell with…”
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14
Eukaryotic microbes, principally fungi and labyrinthulomycetes, dominate biomass on bathypelagic marine snow
Published in The ISME Journal (01-02-2017)“…In the bathypelagic realm of the ocean, the role of marine snow as a carbon and energy source for the deep-sea biota and as a potential hotspot of microbial…”
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15
Monte Carlo simulations for the evaluation of oligomerization data in TOCCSL experiments
Published in Biophysical journal (06-06-2023)“…The interplay and communication between cells build the foundation of life. Many signaling processes at the cell surface and inside the cell, as well as the…”
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16
Elementary Observations: Building Blocks of Physical Information Gain
Published in Entropy (Basel, Switzerland) (23-07-2024)“…In this paper, we are concerned with the process of experimental information gain. Building on previous work, we show that this is a discontinuous process in…”
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17
T‐cell antigen recognition: catch‐as‐catch‐can or catch‐22?
Published in The EMBO journal (03-04-2023)“…T‐cell antigen recognition is invariably affected by tensile forces as they are exerted on T‐cell antigen receptors (TCRs) transiently binding antigenic…”
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Synthesis of naphthalimide-based indicator dyes with a 2-hydroxyethylsulfonyl function for covalent immobilisation to cellulose
Published in Sensors and actuators. B, Chemical (01-12-2018)“…A new approach for the synthesis of 2-hydroxyethylsulfonyl type indicator dyes has been introduced to the naphthalimide chemical structure. Thus, fluorescent…”
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Temporal analysis of T-cell receptor-imposed forces via quantitative single molecule FRET measurements
Published in Nature communications (04-05-2021)“…Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their magnitude, spread,…”
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The asymmetric plasma membrane-A composite material combining different functionalities?: Balancing Barrier Function and Fluidity for Effective Signaling
Published in BioEssays (01-12-2023)“…One persistent puzzle in the life sciences is the asymmetric lipid composition of the cellular plasma membrane: while the exoplasmic leaflet is enriched in…”
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