Search Results - "Gergely, Tamás G."

Characterization of immune checkpoint inhibitor‐induced cardiotoxicity reveals interleukin‐17A as a driver of cardiac dysfunction after anti‐PD‐1 treatment by Gergely, Tamás G., Kucsera, Dániel, Tóth, Viktória E., Kovács, Tamás, Sayour, Nabil V., Drobni, Zsófia D., Ruppert, Mihály, Petrovich, Balázs, Ágg, Bence, Onódi, Zsófia, Fekete, Nóra, Pállinger, Éva, Buzás, Edit I., Yousif, Laura I., Meijers, Wouter C., Radovits, Tamás, Merkely, Béla, Ferdinandy, Péter, Varga, Zoltán V.

“…Background and Purpose Immune checkpoint inhibitors (ICI), such as anti‐PD‐1 monoclonal antibodies, have revolutionized cancer therapy by enhancing the…”
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IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH by Kucsera, Dániel, Tóth, Viktória E., Sayour, Nabil V., Kovács, Tamás, Gergely, Tamás G., Ruppert, Mihály, Radovits, Tamás, Fábián, Alexandra, Kovács, Attila, Merkely, Béla, Ferdinandy, Péter, Varga, Zoltán V.

“…Interleukin-1β (IL-1β) is a key mediator of non-alcoholic steatohepatitis (NASH), a chronic liver disease, and of systemic inflammation-driven aging. IL-1β…”
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Cardioprotective efficacy of limb remote ischaemic preconditioning in rats: discrepancy between a meta-analysis and a three-centre in vivo study by Sayour, Nabil V, Brenner, Gábor B, Makkos, András, Kiss, Bernadett, Kovácsházi, Csenger, Gergely, Tamás G, Aukrust, Sverre Groever, Tian, Huimin, Zenkl, Viktória, Gömöri, Kamilla, Szabados, Tamara, Bencsik, Péter, Heinen, Andre, Schulz, Rainer, Baxter, Gary F, Zuurbier, Coert J, Vokó, Zoltán, Ferdinandy, Péter, Giricz, Zoltán

“…Abstract Aims Remote ischaemic preconditioning (RIPC) is a robust cardioprotective intervention in preclinical studies. To establish a working and efficacious…”
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Effect of hypercholesterolemia on circulating and cardiomyocyte-derived extracellular vesicles by Kovácsházi, Csenger, Hambalkó, Szabolcs, Sayour, Nabil V., Gergely, Tamás G., Brenner, Gábor B., Pelyhe, Csilla, Kapui, Dóra, Weber, Bennet Y., Hültenschmidt, Alexander L., Pállinger, Éva, Buzás, Edit I., Zolcsák, Ádám, Kiss, Bálint, Bozó, Tamás, Csányi, Csilla, Kósa, Nikolett, Kellermayer, Miklós, Farkas, Róbert, Karvaly, Gellért B., Wynne, Kieran, Matallanas, David, Ferdinandy, Péter, Giricz, Zoltán

“…Hypercholesterolemia (HC) induces, propagates and exacerbates cardiovascular diseases via various mechanisms that are yet not properly understood…”
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Effects of Bempedoic Acid in Acute Myocardial Infarction in Rats: No Cardioprotection and No Hidden Cardiotoxicity by Gergely, Tamás G, Brenner, Gábor B, Nagy, Regina N, Sayour, Nabil V, Makkos, András, Kovácsházi, Csenger, Tian, Huimin, Schulz, Rainer, Giricz, Zoltán, Görbe, Anikó, Ferdinandy, Péter

“…Lipid-lowering drugs have been shown to have cardioprotective effects but may have hidden cardiotoxic properties. Therefore, here we aimed to investigate if…”
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Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction by Sayour, Nabil V, Tóth, Viktória É, Nagy, Regina N, Vörös, Imre, Gergely, Tamás G, Onódi, Zsófia, Nagy, Noémi, Bödör, Csaba, Váradi, Barnabás, Ruppert, Mihály, Radovits, Tamás, Bleckwedel, Federico, Zelarayán, Laura C, Pacher, Pal, Ágg, Bence, Görbe, Anikó, Ferdinandy, Péter, Varga, Zoltán V

“…The identification of novel drug targets is needed to improve the outcomes of heart failure (HF). G-protein-coupled receptors (GPCRs) represent the largest…”
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Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice by Sayour, Nabil V., Kucsera, Dániel, Alhaddad, Ayham R., Tóth, Viktória É., Gergely, Tamás G., Kovács, Tamás, Hegedűs, Zsombor I., Jakab, Márk E., Ferdinandy, Péter, Varga, Zoltán V.

“…Abstract Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities on the manifestation and…”
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Reduced circulating CD63 + extracellular vesicle levels associate with atherosclerosis in hypercholesterolaemic mice and humans by Kestecher, Brachyahu M, Németh, Krisztina, Ghosal, Sayam, Sayour, Nabil V, Gergely, Tamás G, Bodnár, Bernadett R, Försönits, András I, Sódar, Barbara W, Oesterreicher, Johannes, Holnthoner, Wolfgang, Varga, Zoltán V, Giricz, Zoltán, Ferdinandy, Péter, Buzás, Edit I, Osteikoetxea, Xabier

“…The association and co-isolation of low-density lipoproteins (LDL) and extracellular vesicles (EVs) have been shown in blood plasma. Here we explore this…”
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Rosiglitazone Does Not Show Major Hidden Cardiotoxicity in Models of Ischemia/Reperfusion but Abolishes Ischemic Preconditioning-Induced Antiarrhythmic Effects in Rats In Vivo by Weber, Bennet Y, Brenner, Gábor B, Kiss, Bernadett, Gergely, Tamás G, Sayour, Nabil V, Tian, Huimin, Makkos, András, Görbe, Anikó, Ferdinandy, Péter, Giricz, Zoltán

“…Clinical observations are highly inconsistent with the use of the antidiabetic rosiglitazone regarding its associated increased risk of myocardial infarction…”
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Saxagliptin Cardiotoxicity in Chronic Heart Failure: The Role of DPP4 in the Regulation of Neuropeptide Tone by Vörös, Imre, Onódi, Zsófia, Tóth, Viktória Éva, Gergely, Tamás G, Sághy, Éva, Görbe, Anikó, Kemény, Ágnes, Leszek, Przemyslaw, Helyes, Zsuzsanna, Ferdinandy, Péter, Varga, Zoltán V

“…Dipeptidyl-peptidase-4 (DPP4) inhibitors are novel medicines for diabetes. The SAVOR-TIMI-53 clinical trial revealed increased heart-failure-associated…”
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Comparison of mouse models of heart failure with reduced ejection fraction by Sayour, Nabil V, Gergely, Tamás G, Váradi, Barnabás, Tóth, Viktória É, Ágg, Bence, Kovács, Tamás, Kucsera, Dániel, Kovácsházi, Csenger, Brenner, Gábor B, Giricz, Zoltán, Ferdinandy, Péter, Varga, Zoltán V

“…Heart failure with reduced ejection fraction (HFrEF) is a leading cause of death worldwide; thus, therapeutic improvements are needed. In vivo preclinical…”
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Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion by Brenner, Gábor B, Makkos, András, Nagy, Csilla Terézia, Onódi, Zsófia, Sayour, Nabil V, Gergely, Tamás G, Kiss, Bernadett, Görbe, Anikó, Sághy, Éva, Zádori, Zoltán S, Lázár, Bernadette, Baranyai, Tamás, Varga, Richárd S, Husti, Zoltán, Varró, András, Tóthfalusi, László, Schulz, Rainer, Baczkó, István, Giricz, Zoltán, Ferdinandy, Péter

“…Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept…”
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Systematic transcriptomic and phenotypic characterization of human and murine cardiac myocyte cell lines and primary cardiomyocytes reveals serious limitations and low resemblances to adult cardiac phenotype by Onódi, Zsófia, Visnovitz, Tamás, Kiss, Bernadett, Hambalkó, Szabolcs, Koncz, Anna, Ágg, Bence, Váradi, Barnabás, Tóth, Viktória É., Nagy, Regina N., Gergely, Tamás G., Gergő, Dorottya, Makkos, András, Pelyhe, Csilla, Varga, Nóra, Reé, Dóra, Apáti, Ágota, Leszek, Przemyslaw, Kovács, Tamás, Nagy, Nándor, Ferdinandy, Péter, Buzás, Edit I., Görbe, Anikó, Giricz, Zoltán, Varga, Zoltán V.

“…Cardiac cell lines and primary cells are widely used in cardiovascular research. Despite increasing number of publications using these models, comparative…”
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Molecular fingerprints of cardiovascular toxicities of immune checkpoint inhibitors by Gergely, Tamás G, Drobni, Zsófia D, Sayour, Nabil V, Ferdinandy, Péter, Varga, Zoltán V

“…Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by unleashing the power of the immune system against malignant cells. However, their use…”
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Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure by Gergely, Tamás G., Drobni, Zsófia D., Kallikourdis, Marinos, Zhu, Han, Meijers, Wouter C., Neilan, Tomas G., Rassaf, Tienush, Ferdinandy, Péter, Varga, Zoltán V.

“…Immune checkpoint molecules are physiological regulators of the adaptive immune response. Immune checkpoint inhibitors (ICIs), such as monoclonal antibodies…”
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The changes in the pharmacotherapy of heart failure with reduced ejection fraction and its effect on prognosis: experience in the Hungarian clinical practice by Muk, Balázs, Pilecky, Dávid, Bánfi-Bacsárdi, Fanni, Füzesi, Tamás, Gergely, G Tamás, Komáromi, Anna, Papp, Emese, Szőnyi, Mihály Dániel, Forrai, Zsolt, Kazay, Ádám, Solymossi, Balázs, Vámos, Máté, Andréka, Péter, Piróth, Zsolt, Nyolczas, Noémi

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CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling by Gergely, Tamás G., Kovács, Tamás, Kovács, Andrea, Tóth, Viktória E., Sayour, Nabil V., Mórotz, Gábor M., Kovácsházi, Csenger, Brenner, Gábor B., Onódi, Zsófia, Enyedi, Balázs, Máthé, Domokos, Leszek, Przemyslaw, Giricz, Zoltán, Ferdinandy, Péter, Varga, Zoltán V.

“…Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte…”
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Molecular determinants of immune checkpoint inhibitor-induced cardiac dysfunction: comparison of PD-1 inhibitor treated C57BL/6J and BALB/c mice by Gergely, Tamás G., Kucsera, Dániel, Tóth, Viktória E., Ruppert, Mihály, Petrovich, Balázs, Ágg, Bence, Onódi, Zsófia, Radovits, Tamás, Merkely, Béla, Ferdinandy, Péter, Varga, Zoltan

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Arrhythmogenic right ventricular cardiomyopathy with sinus node dysfunction by Gergely G. Tamás, Bánfi-Bacsárdi Fanni, Pilecky Dávid, Szűcs Gábor, Hajkó Erik, Hámory Eszter, Som Zoltán, Tóth Attila, Muk Balázs, Borbás Sarolta

“…Introduction: The 2023 European Society of Cardiology Guidelines for the management of Cardiomyopathies recommends a phenotype-based, multimodal,…”
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Aritmogén jobb kamrai cardiomyopathia sinuscsomó-diszfunkcióval by Gergely, G. Tamás, Bánfi-Bacsárdi, Fanni, Pilecky, Dávid, Szűcs, Gábor, Hajkó, Erik, Hámory, Eszter, Som, Zoltán, Tóth, Attila, Muk, Balázs, Borbás, Sarolta

“…Bevezetés: Az Európai Kardiológus Társaság 2023-as Cardiomyopathia Irányelve a cardiomyopathiák fenotípus-alapú megközelítését javasolja, a diagnózis…”
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