Search Results - "Gergő, Mótyán"

Microwave-Assisted Stereoselective Heterocyclization to Novel Ring d-fused Arylpyrazolines in the Estrone Series by Mótyán, Gergő, Molnár, Barnabás, Wölfling, János, Frank, Éva

“…Microwave-assisted syntheses of novel ring d-condensed 2-pyrazolines in the estrone series were efficiently carried out from steroidal ,-enones and hydrazine…”
Get full text

Lewis acid-induced intramolecular access to novel steroidal ring D-condensed arylpyrazolines exerting in vitro cell-growth-inhibitory effects by Mótyán, Gergő, Zupkó, István, Minorics, Renáta, Schneider, Gyula, Wölfling, János, Frank, Éva

“…Novel androstenoarylpyrazolines were synthesized stereoselectively by the BF 3 -induced intramolecular 1,3-dipolar cycloaddition of alkenyl hydrazones obtained…”
Get full text

Regio- and stereoselective synthesis of pregnane-fused isoxazolines by nitril-oxide/alkene 1,3-dipolar cycloaddition and an evaluation of their cell-growth inhibitory effect in vitro by Motyan, Gergo, Baji, Adam, Zupko, Istvan, Frank, Eva

“…Efficient syntheses of some pregnane-fused isoxazolines from 16-dehydropregnenolone acetate with different arylnitrile oxides were carried out by 1,3-dipolar…”
Get full text

Regio- and stereoselective access to novel ring-condensed steroidal isoxazolines by Mótyán, Gergő, Kádár, Zalán, Kovács, Dóra, Wölfling, János, Frank, Éva

“…•Isoxazoline hetero rings were introduced into the sterane nucleus.•Intermolecular alkene–nitrile oxide cycloadditions were carried out.•The reactivities of…”
Get full text

Regioselective synthesis, physicochemical properties and anticancer activity of 2-aminomethylated estrone derivatives by Molnár, Barnabás, Kinyua, Njangiru Isaac, Mótyán, Gergő, Leits, Péter, Zupkó, István, Minorics, Renáta, Balogh, György T., Frank, Éva

“…[Display omitted] •Regioselective A-ring-aminomethylation of estrone was developed.•aza-Michael addition of secondary amines to an o-QM intermediate was…”
Get full text

Dynamics of hydroxide-ion-driven reversible autocatalytic networks by Lantos, Emese, Mótyán, Gerg, Frank, Éva, Eelkema, Rienk, van Esch, Jan, Horváth, Dezs, Tóth, Ágota

“…In living systems adaptive regulation requires the presence of nonlinear responses in the underlying chemical networks. Positive feedbacks, for example, can…”
Get full text

Microwave-assisted stereoselective approach to novel steroidal ring D-fused 2-pyrazolines and an evaluation of their cell-growth inhibitory effects in vitro by Mótyán, Gergő, Kovács, Ferenc, Wölfling, János, Gyovai, András, Zupkó, István, Frank, Éva

“…•Microwave-assisted reactions of 16-dehydropregnenolone and hydrazines were carried out.•Pyrazoline heteroring was introduced into ring D of the sterane…”
Get full text

A-ring-fused pyrazoles of dihydrotestosterone targeting prostate cancer cells via the downregulation of the androgen receptor by Peřina, Miroslav, Kiss, Márton A., Mótyán, Gergő, Szczyrbová, Eva, Eliáš, Martin, Študent jr, Vladimír, Kurfürstová, Daniela, Kovalová, Markéta, Mada, Lukáš, Bouchal, Jan, Frank, Éva, Jorda, Radek

“…High expression of the androgen receptor (AR) and the disruption of its regulation are strongly responsible for the development of prostate cancer (PCa)…”
Get full text

Anti-Cancer Activity of Novel Dihydrotestosterone-Derived Ring A-Condensed Pyrazoles on Androgen Non-Responsive Prostate Cancer Cell Lines by Mótyán, Gergő, Gopisetty, Mohana Krishna, Kiss-Faludy, Réka Eleonóra, Kulmány, Ágnes, Zupkó, István, Frank, Éva, Kiricsi, Mónika

“…Regioselective synthesis of novel ring A-fused arylpyrazoles of dihydrotestosterone (DHT) was carried out in two steps under facile reaction conditions. Aldol…”
Get full text

A facile access to novel steroidal 17-2'-(1',3',4')-oxadiazoles, and an evaluation of their cytotoxic activities in vitro by Kovacs, Dora, Motyan, Gergo, Wolfling, Janos, Kovacs, Ida, Zupko, Istvan, Frank, Eva

“…Novel types of 17-exo-heterocycles in the Δ(5) androstene series carrying an 1,3,4-oxadiazole moiety were efficiently synthesized via aldehyde N-acylhydrazone…”
Get full text

Microwave-assisted synthesis of biologically relevant steroidal 17- exo -pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence by Mótyán, Gergő, Mérai, László, Kiss, Márton Attila, Schelz, Zsuzsanna, Sinka, Izabella, Zupkó, István, Frank, Éva

“…Multistep syntheses of novel 17β-pyrazol-5'-ones in the Δ -androstane series were efficiently carried out from pregnenolone acetate. A steroidal 17-carboxylic…”
Get full text

Microwave-Assisted Synthesis, Proton Dissociation Processes, and Anticancer Evaluation of Novel D-Ring-Fused Steroidal 5-Amino-1-Arylpyrazoles by Mótyán, Gergő, Baji, Ádám, Marć, Małgorzata Anna, Gopisetty, Mohana Krishna, Adamecz, Dóra I., Kiricsi, Mónika, Enyedy, Éva A., Frank, Éva

“…Taking into account the pharmacological relevance of heterocycle-fused natural steroids, the objective of the current study was to develop a multistep reaction…”
Get full text

Szteránvázhoz kondenzált öttagú heterociklusos vegyületek szintézise by Gergő, Mótyán

“…A doktori munkám során sikeresen megvalósítottuk előzetes célkitűzéseinket, és nemi hormon vázak A- és D- gyűrűihez kondenzált öttagú heterociklusos vegyületek…”
Get full text

Investigation of pH and substituent effects on the distribution ratio of novel steroidal ring D- and A-fused arylpyrazole regioisomers and evaluation of their cell-growth inhibitory effects in vitro by Baji, Ádám, Kovács, Ferenc, Mótyán, Gergő, Schneider, Gyula, Wölfling, János, Sinka, Izabella, Zupkó, István, Ocsovszki, Imre, Frank, Éva

“…[Display omitted] •Knorr reactions of steroidal β-ketoaldehydes with arylhydrazines were carried out.•Pyrazole heteroring was introduced into rings D and A of…”
Get full text

Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro by Berényi, Ágnes, Minorics, Renáta, Iványi, Zoltán, Ocsovszki, Imre, Ducza, Eszter, Thole, Hubert, Messinger, Josef, Wölfling, János, Mótyán, Gergő, Mernyák, Erzsébet, Frank, Éva, Schneider, Gyula, Zupkó, István

“…► Antiproliferative screen of 63 newly synthetized estrone-16-oxime ethers. ► Disturbance of cell cycle and apoptosis induction. ► Action mediated via proteins…”
Get full text

Synthesis, characterization and biological evaluation of some novel 17-isoxazoles in the estrone series by Kovács, Dóra, Kádár, Zalán, Mótyán, Gergő, Schneider, Gyula, Wölfling, János, Zupkó, István, Frank, Éva

“…► Efficient syntheses of novel steroidal 17-isoxazoles. ► Cu(I)-catalyzed alkyne–nitrile oxide cycloadditions were carried out. ► The structures of all novel…”
Get full text