Search Results - "Gerfen, Gary J."

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine by Briggs, Kimberly J., Koivunen, Peppi, Cao, Shugeng, Backus, Keriann M., Olenchock, Benjamin A., Patel, Hetalben, Zhang, Qing, Signoretti, Sabina, Gerfen, Gary J., Richardson, Andrea L., Witkiewicz, Agnieszka K., Cravatt, Benjamin F., Clardy, Jon, Kaelin, William G.

“…The HIF transcription factor promotes adaptation to hypoxia and stimulates the growth of certain cancers, including triple-negative breast cancer (TNBC). The…”
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The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe–2S cluster by Bashiri, Ghader, Grove, Tyler L., Hegde, Subray S., Lagautriere, Thomas, Gerfen, Gary J., Almo, Steven C., Squire, Christopher J., Blanchard, John S., Baker, Edward N.

“…Iron–sulfur clusters are protein cofactors with an ancient evolutionary origin. These clusters are best known for their roles in redox proteins such as…”
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Biosynthesis and Functions of a Melanoid Pigment Produced by Species of the Sporothrix Complex in the Presence of l-Tyrosine by Almeida-Paes, Rodrigo, Frases, Susana, Araújo, Glauber de Sousa, de Oliveira, Manoel Marques Evangelista, Gerfen, Gary J., Nosanchuk, Joshua D., Zancopé-Oliveira, Rosely Maria

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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An Oxyferrous Heme/Protein-based Radical Intermediate Is Catalytically Competent in the Catalase Reaction of Mycobacterium tuberculosis Catalase-Peroxidase (KatG) by Suarez, Javier, Ranguelova, Kalina, Jarzecki, Andrzej A., Manzerova, Julia, Krymov, Vladimir, Zhao, Xiangbo, Yu, Shengwei, Metlitsky, Leonid, Gerfen, Gary J., Magliozzo, Richard S.

“…A mechanism accounting for the robust catalase activity in catalase-peroxidases (KatG) presents a new challenge in heme protein enzymology. In Mycobacterium…”
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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants by Wu, Haiyan, Shekar, S. Chandra, Flinn, Rory J, El-Sibai, Mirvat, Jaiswal, Bijay S, Sen, K. Ilker, Janakiraman, Vasantharajan, Seshagiri, Somasekar, Gerfen, Gary J, Girvin, Mark E, Backer, Jonathan M

“…We previously proposed a model of Class IA PI3K regulation in which p85 inhibition of p110α requires (i) an inhibitory contact between the p85 nSH2 domain and…”
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Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule by Chatterjee, Chandrima, Benoit, Matthieu P.M.H., DePaoli, Vania, Diaz-Valencia, Juan D., Asenjo, Ana B., Gerfen, Gary J., Sharp, David J., Sosa, Hernando

“…Kinesins-13s are members of the kinesin superfamily of motor proteins that depolymerize microtubules (MTs) and have no motile activity. Instead of generating…”
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Two Tyrosyl Radicals Stabilize High Oxidation States in Cytochrome c Oxidase for Efficient Energy Conservation and Proton Translocation by Yu, Michelle A, Egawa, Tsuyoshi, Shinzawa-Itoh, Kyoko, Yoshikawa, Shinya, Guallar, Victor, Yeh, Syun-Ru, Rousseau, Denis L, Gerfen, Gary J

“…The reaction of oxidized bovine cytochrome c oxidase (bCcO) with hydrogen peroxide (H2O2) was studied by electron paramagnetic resonance (EPR) to determine the…”
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Copper Coordination in the Full-Length, Recombinant Prion Protein by Burns, Colin S, Aronoff-Spencer, Eliah, Legname, Giuseppe, Prusiner, Stanley B, Antholine, William E, Gerfen, Gary J, Peisach, Jack, Millhauser, Glenn L

“…The prion protein (PrP) binds divalent copper at physiologically relevant conditions and is believed to participate in copper regulation or act as a…”
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Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein by Burns, Colin S, Aronoff-Spencer, Eliah, Dunham, Christine M, Lario, Paula, Avdievich, Nikolai I, Antholine, William E, Olmstead, Marilyn M, Vrielink, Alice, Gerfen, Gary J, Peisach, Jack, Scott, William G, Millhauser, Glenn L

“…Recent evidence suggests that the prion protein (PrP) is a copper binding protein. The N-terminal region of human PrP contains four sequential copies of the…”
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Catalytic Intermediates of Inducible Nitric-oxide Synthase Stabilized by the W188H Mutation by Sabat, Joseph, Egawa, Tsuyoshi, Lu, Changyuan, Stuehr, Dennis J., Gerfen, Gary J., Rousseau, Denis L., Yeh, Syun-Ru

“…Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: l-arginine (l-Arg) → N-hydroxy-l-arginine → citrulline + NO. In the…”
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Identification of the Cu2+ Binding Sites in the N-Terminal Domain of the Prion Protein by EPR and CD Spectroscopy by Aronoff-Spencer, Eliah, Burns, Colin S, Avdievich, Nikolai I, Gerfen, Gary J, Peisach, Jack, Antholine, William E, Ball, Haydn L, Cohen, Fred E, Prusiner, Stanley B, Millhauser, Glenn L

“…Recent evidence indicates that the prion protein (PrP) plays a role in copper metabolism in the central nervous system. The N-terminal region of human PrP…”
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EPR Spectroscopic and Computational Characterization of the Hydroxyethylidene-Thiamine Pyrophosphate Radical Intermediate of Pyruvate:Ferredoxin Oxidoreductase by Mansoorabadi, Steven O, Seravalli, Javier, Furdui, Cristina, Krymov, Vladimir, Gerfen, Gary J, Begley, Tadhg P, Melnick, Jonathan, Ragsdale, Stephen W, Reed, George H

“…The radical intermediate of pyruvate:ferredoxin oxidoreductase (PFOR) from Moorella thermoacetica was characterized using electron paramagnetic resonance (EPR)…”
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Polarization-Enhanced NMR Spectroscopy of Biomolecules in Frozen Solution by Hall, Dennis A., Maus, Douglas C., Gerfen, Gary J., Inati, Souheil J., Becerra, Lino R., Dahlquist, Frederick W., Griffin, Robert G.

“…Large dynamic nuclear polarization signal enhancements (up to a factor of 100) were obtained in the solid-state magic-angle spinning nuclear magnetic resonance…”
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Thiyl Radicals in Ribonucleotide Reductases by Licht, Stuart, Gerfen, Gary J., Stubbe, JoAnne

“…The ribonucleoside triphosphate reductase (RTPR) from Lactobacillus leichmannii catalyzes adenosylcobalamin (AdoCbl)-dependent nucleotide reduction, as well as…”
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Radical Sites in Mycobacterium tuberculosis KatG Identified Using Electron Paramagnetic Resonance Spectroscopy, the Three-dimensional Crystal Structure, and Electron Transfer Couplings by Ranguelova, Kalina, Girotto, Stefania, Gerfen, Gary J., Yu, Shengwei, Suarez, Javier, Metlitsky, Leonid, Magliozzo, Richard S.

“…Catalase-peroxidase (KatG) from Mycobacterium tuberculosis, a Class I peroxidase, exhibits high catalase activity and peroxidase activity with various…”
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GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop by Giacco, Ferdinando, Du, Xueliang, Carratú, Anna, Gerfen, Gary J, D'Apolito, Maria, Giardino, Ida, Rasola, Andrea, Marin, Oriano, Divakaruni, Ajit S, Murphy, Anne N, Shah, Manasi S, Brownlee, Michael

“…The assumption underlying current diabetes treatment is that lowering the level of time-averaged glucose concentrations, measured as HbA1c, prevents…”
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Determination of the Structural Environment of the Tyrosyl Radical in Prostaglandin H2 Synthase-1:  A High Frequency ENDOR/EPR Study by Wilson, John C, Wu, Gang, Tsai, Ah-lim, Gerfen, Gary J

“…The catalytically active tyrosyl radical which gives rise to the “wide doublet” (WD1) signal in ovine Prostaglandin H2 Synthase-1 has been studied using high…”
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High-Field EPR Study of Tyrosyl Radicals in Prostaglandin H2 Synthase-1 by Dorlet, Pierre, Seibold, Steve A, Babcock, Gerald T, Gerfen, Gary J, Smith, William L, Tsai, Ah-lim, Un, Sun

“…Various tyrosyl radicals generated by reaction of both native and indomethacin-inhibited ovine prostaglandin H synthase-1 with ethyl hydrogen peroxide were…”
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Oxidative decarboxylation of pyruvate by 1-deoxy-d-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria by DeColli, Alicia A., Nemeria, Natalia S., Majumdar, Ananya, Gerfen, Gary J., Jordan, Frank, Freel Meyers, Caren L.

“…The underexploited antibacterial target 1-deoxy-d-xyluose 5-phosphate (DXP) synthase catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from…”
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Narrow-Spectrum Antibiotic Targeting of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis by Carl, Ayala G, Harris, Lawrence D, Feng, Mu, Nordstrøm, Lars U, Gerfen, Gary J, Evans, Gary B, Silakov, Alexey, Almo, Steven C, Grove, Tyler L

“…Antibiotic resistance continues to spread at an alarming rate, outpacing the introduction of new therapeutics and threatening to globally undermine health…”
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