Search Results - "Gerez, Juan Atilio"
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A protein's structure used to diagnose disease
Published in Nature (London) (13-02-2020)“…[...]it should be noted that the samples analysed in this study were obtained from people who had already been diagnosed, and it remains unclear whether the…”
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2
Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein
Published in PLoS pathogens (01-04-2013)“…Respiratory Syncytial Virus (RSV) is a highly pathogenic member of the Paramyxoviridae that causes severe respiratory tract infections. Reports in the…”
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3
Multi‐Dimensional Structure and Dynamics Landscape of Proteins in Mammalian Cells Revealed by In‐Cell NMR
Published in Angewandte Chemie International Edition (23-01-2023)“…Governing function, half‐life and subcellular localization, the 3D structure and dynamics of proteins are in nature constantly changing in a tightly regulated…”
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4
Cell-to-cell transmitted alpha-synuclein recapitulates experimental Parkinson’s disease
Published in NPJ Parkinson's Disease (06-01-2024)“…Parkinson’s disease is characterized by a progressive accumulation of alpha-Synuclein (αSyn) neuronal inclusions called Lewy bodies in the nervous system. Lewy…”
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Neurodegenerative diseases distinguished through protein-structure analysis
Published in Nature (London) (13-02-2020)“…Parkinson’s disease and multiple system atrophy involve the protein α-synuclein. Proof that aggregated α-synuclein adopts a different structure in each case…”
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α-Synuclein aggregation nucleates through liquid–liquid phase separation
Published in Nature chemistry (01-08-2020)“…α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with Parkinson’s disease pathogenesis. However, the early events involved in this…”
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7
Multi‐Dimensional Structure and Dynamics Landscape of Proteins in Mammalian Cells Revealed by In‐Cell NMR
Published in Angewandte Chemie (23-01-2023)“…Governing function, half‐life and subcellular localization, the 3D structure and dynamics of proteins are in nature constantly changing in a tightly regulated…”
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8
More than a Rumor Spreads in Parkinson's Disease
Published in Frontiers in human neuroscience (02-12-2016)“…As Parkinson's disease progresses, a massive loss of dopaminergic neurons is accompanied by accumulation of alpha-Synuclein (αSyn) neuronal inclusions called…”
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Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity
Published in Cell systems (25-09-2019)“…Proteinaceous inclusions containing alpha-synuclein (α-Syn) have been implicated in neuronal toxicity in Parkinson's disease, but the pathways that modulate…”
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Host Cell Entry of Respiratory Syncytial Virus Involves Macropinocytosis Followed by Proteolytic Activation of the F Protein: e1003309
Published in PLoS pathogens (01-04-2013)“…Respiratory Syncytial Virus (RSV) is a highly pathogenic member of the Paramyxoviridae that causes severe respiratory tract infections. Reports in the…”
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