Search Results - "Gerenser, Pamela"

Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor by Morissette, Pierre, Li, Nianyu, Ballard, Jeanine E, Vavrek, Marissa, Adams, Gregory L, Regan, Chris, Regan, Hillary, Lee, K J, Wang, Weixun, Burton, Aimee, Chen, Feifei, Gerenser, Pamela, Li, Yuxing, Kraus, Richard L, Tellers, David, Palani, Anand, Zhu, Yuping, Sun, Chengzao, Bianchi, Elisabetta, Colarusso, Stefania, De Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Amin, Rupesh P

“…Abstract Studies have shown that some peptides and small molecules can induce non IgE-mediated anaphylactoid reactions through mast cell activation. Upon…”
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Assessment of the clinical cardiac drug‐drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys by Regan, Christopher P., Morissette, Pierre, Regan, Hillary K., Travis, Jeffery J., Gerenser, Pamela, Wen, Jianzhong, Fitzgerald, Kevin, Gruver, Shaun, DeGeorge, Joseph J., Sannajust, Frederick J.

“…In 2015, European and U.S. health agencies issued warning letters in response to 9 reported clinical cases of severe bradycardia/bradyarrhythmia in hepatitis C…”
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Comparative Evaluation of In Silico Models to Assess Cardiac Pro-arrhythmic Risk in Early Drug Development by Morissette, Pierre, Travis, Jeffrey, Gerenser, Pamela, Fanelli, Patrick, Chain, Anne, Dech, Spencer, Regan, Christopher, Sannajust, Frederick

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A Preclinical Paradigm to Assess the Potential Risk and In Vivo Mechanism(s) Responsible for the Bradyarrhythmia Observed in Hepatitis-C Virus (HCV) Infected Patients Treated with Direct-Acting Antivirals (DAAs) and Amiodarone by Regan, Christopher, Morissette, Pierre, Travis, Jeffery, Gerenser, Pamela, Gruver, Shaun, Fitzgerald, Kevin, Regan, Hillary, Sannajust, Frederick

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Torsadogenic drugs shorten the cardiac electromechanical window before prolonging the QTc interval in anesthetized guinea pigs by Morissette, Pierre, Travis, Jeffrey, Gerenser, Pamela, Regan, Christopher, Sannajust, Frederick

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Successful integrative approach of the pro-arrhythmic risk assessment of the multichannel ion channel inhibitor vanoxerine, via combination of in silico human cardiomyocyte models and in vivo guinea-pig electromechanical window assay by Morissette, Pierre, Gerenser, Pamela, Travis, Jeffrey, Fanelli, Patrick, Balasubramanian, Bharathi, Passini, Elisa, Bueno-Orovio, Alfonso, Rodriguez, Blanca, Regan, Christopher, Sannajust, Frederick

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QT interval correction assessment in the anesthetized guinea pig by Morissette, Pierre, Regan, Hillary K., Fitzgerald, Kevin, Bernasconi, Sylvain, Gerenser, Pamela, Travis, Jeffrey, Fanelli, Patrick, Sannajust, Frederick, Regan, Christopher P.

“…The anesthetized guinea pig (ANES GP) has proven to be an effective small animal model to evaluate cardiac electrophysiologic effects of drug-candidate…”
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QT interval correction assessment in the ketamine/xylazine-anesthetized guinea pig model by Travis, Jeffrey, Morissette, Pierre, Regan, Hillary, Fitzgerald, Kevin, Bernasconi, Sylvain, Gerenser, Pamela, Fanelli, Patrick, Regan, Christopher, Sannajust, Frederick

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The anesthetized guinea pig: An effective early cardiovascular derisking and lead optimization model by Morissette, Pierre, Nishida, Masahiro, Trepakova, Elena, Imredy, John, Lagrutta, Armando, Chaves, Alysia, Hoagland, Kimberly, Hoe, Chao-Min Lei, Zrada, Matthew M., Travis, Jeffrey J., Zingaro, Gloria J., Gerenser, Pamela, Friedrichs, Greg, Salata, Joseph J.

“…In recent years, the anesthetized guinea pig has been used increasingly to evaluate the cardiovascular effects of drug-candidate molecules during lead…”
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Translation of hemodynamic effects between anesthetized guinea pig and conscious rat models by Gerenser, Pamela, Zingaro, Gloria, Travis, Jeffrey, Hoagland, Kimberly, Chaves, Alysia, Friedrichs, Gregory, Morissette, Pierre

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Reducing animal use by refining experimental paradigms and colony management in a conscious rat telemetry model by Garfinkel, Ivy, Hasbun-Manning, Martha, Ferraro, Jude, Fanelli, Patrick, Gerenser, Pamela, Deng, Min, Fitzgerald, Lisa, Friedrichs, Gregory, Salata, Joseph, Hoe, Chao-Min, Hoagland, Kimberly

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Predictive value of the anesthetized guinea pig model to conscious animal models and humans by Morissette, Pierre, Nishida, Masahiro, Trepakova, Elena, Travis, Jeffrey J., Zingaro, Gloria, Gerenser, Pamela, Chaves, Alysia, Hoagland, Kimberly, Friedrichs, Gregory, Salata, Joseph

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Anesthetized guinea pig is an effective and efficient cardiovascular safety pharmacology screening model by Morissette, Pierre, Nishida, Masahiro, Travis, Jeff, Steve, Desiree, Zingaro, Gloria, Gerenser, Pamela, Grady-Styring, Tara, Woltmann, Richard, Salata, Joseph

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