Search Results - "Geremia, Raffaele"

An Orchestrated Intron Retention Program in Meiosis Controls Timely Usage of Transcripts during Germ Cell Differentiation by Naro, Chiara, Jolly, Ariane, Di Persio, Sara, Bielli, Pamela, Setterblad, Niclas, Alberdi, Antonio J., Vicini, Elena, Geremia, Raffaele, De la Grange, Pierre, Sette, Claudio

“…Global transcriptome reprogramming during spermatogenesis ensures timely expression of factors in each phase of male germ cell differentiation. Spermatocytes…”
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Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin by Busà, Roberta, Geremia, Raffaele, Sette, Claudio

“…DNA-damaging agents cause a multifaceted cellular stress response. Cells set in motion either repair mechanisms or programmed cell death pathways, depending on…”
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The Endocannabinoid System and Pivotal Role of the CB₂ Receptor in Mouse Spermatogenesis by Grimaldi, Paola, Orlando, Pierangelo, Di Siena, Sara, Lolicato, Francesca, Petrosino, Stefania, Bisogno, Tiziana, Geremia, Raffaele, De Petrocellis, Luciano, Di Marzo, Vincenzo, Yanagimachi, Ryuzo

“…The exact role of the endocannabinoid system (ECS) during spermatogenesis has not been clarified. We used purified germ cell fractions representative of all…”
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Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells by Bianchini, Andrea, Loiarro, Maria, Bielli, Pamela, Busà, Roberta, Paronetto, Maria Paola, Loreni, Fabrizio, Geremia, Raffaele, Sette, Claudio

“…Deregulation of the phosphatidyl inositol trisphosphate kinase/AKT/mammalian target of rapamycin (mTOR) and RAS/mitogen-activated protein kinase (MAPK)/MNK…”
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Effect Of Microgravity On Aromatase Expression In Sertoli Cells by Cirelli, Elisa, De Domenico, Emanuela, Botti, Flavia, Massoud, Renato, Geremia, Raffaele, Grimaldi, Paola

“…Cytochrome P450-aromatase catalyzes estrogen biosynthesis from C 19 steroids. In the testis, Sertoli cells express P450-aromatase and represent the primary…”
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ATRA and KL promote differentiation toward the meiotic program of male germ cells by Pellegrini, Manuela, Filipponi, Doria, Gori, Manuele, Barrios, Florencia, Lolicato, Francesca, Grimaldi, Paola, Rossi, Pellegrino, Jannini, Emmanuele A., Geremia, Raffaele, Dolci, Susanna

“…While it is known that Retinoic Acid (RA) induces meiosis in mouse female fetal gonads, the mechanisms which regulate this process during spermatogenesis are…”
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Developmental expression of BMP4/ALK3/SMAD5 signaling pathway in the mouse testis: a potential role of BMP4 in spermatogonia differentiation by Pellegrini, Manuela, Grimaldi, Paola, Rossi, Pellegrino, Geremia, Raffaele, Dolci, Susanna

“…It is well established that the c-kit gene plays an essential role in the proliferation of differentiating spermatogonia in prepuberal mice. However, the…”
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Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population by Lolicato, Francesca, Marino, Rita, Paronetto, Maria Paola, Pellegrini, Manuela, Dolci, Susanna, Geremia, Raffaele, Grimaldi, Paola

“…Nanos gene encodes for zinc-finger protein with putative RNA-binding activity which shows an evolutionary conserved function in germ cell development. In the…”
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Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas by Barbagallo, Federica, Paronetto, Maria P, Franco, Renato, Chieffi, Paolo, Dolci, Susanna, Fry, Andrew M, Geremia, Raffaele, Sette, Claudio

“…Protein kinases that regulate the centrosome cycle are often aberrantly controlled in neoplastic cells. Changes in their expression or activity can lead to…”
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The RNA binding protein SAM68 transiently localizes in the chromatoid body of male germ cells and influences expression of select microRNAs by Messina, Valeria, Meikar, Oliver, Paronetto, Maria Paola, Calabretta, Sara, Geremia, Raffaele, Kotaja, Noora, Sette, Claudio

“…The chromatoid body (CB) is a unique structure of male germ cells composed of thin filaments that condense into a perinuclear organelle after meiosis. Due to…”
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Microgravity promotes differentiation and meiotic entry of postnatal mouse male germ cells by Pellegrini, Manuela, Di Siena, Sara, Claps, Giuseppina, Di Cesare, Silvia, Dolci, Susanna, Rossi, Pellegrino, Geremia, Raffaele, Grimaldi, Paola

“…A critical step of spermatogenesis is the entry of mitotic spermatogonia into meiosis. Progresses on these topics are hampered by the lack of an in vitro…”
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Src kinase activity coordinates cell adhesion and spreading with activation of mammalian target of rapamycin in pancreatic endocrine tumour cells by Di Florio, Alessia, Adesso, Laura, Pedrotti, Simona, Capurso, Gabriele, Pilozzi, Emanuela, Corbo, Vincenzo, Scarpa, Aldo, Geremia, Raffaele, Delle Fave, Gianfranco, Sette, Claudio

“…Pancreatic endocrine tumours (PETs) are rare and heterogeneous neoplasms, often diagnosed at metastatic stage, for which no cure is currently available…”
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Signaling through Extracellular Signal-regulated Kinase Is Required for Spermatogonial Proliferative Response to Stem Cell Factor by Dolci, Susanna, Pellegrini, Manuela, Di Agostino, Silvia, Geremia, Raffaele, Rossi, Pellegrino

“…In vitro addition of stem cell factor (SCF) to c-kit-expressing A1–A4spermatogonia from prepuberal mice stimulates their progression into the mitotic cell…”
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tr-kit promotes the formation of a multimolecular complex composed by Fyn, PLCγ1 and Sam68 by PARONETTO, Maria Paola, VENABLES, Julian P, ELLIOTT, David J, GEREMIA, Raffaele, ROSSI, Pellegrino, SETTE, Claudio

“…tr-kit is a truncated form of the tyrosine kinase receptor c-kit expressed in the haploid phase of spermatogenesis. Upon microinjection, tr-kit triggers…”
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Src family kinase activity regulates adhesion, spreading and migration of pancreatic endocrine tumour cells by Di Florio, Alessia, Capurso, Gabriele, Milione, Massimo, Panzuto, Francesco, Geremia, Raffaele, Fave, Gianfranco Delle, Sette, Claudio

“…Pancreatic endocrine tumours (PETs) are rare and ‘indolent’ neoplasms that usually develop metastatic lesions and exhibit poor response to standard medical…”
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Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes by Di Agostino, Silvia, Fedele, Monica, Chieffi, Paolo, Fusco, Alfredo, Rossi, Pellegrino, Geremia, Raffaele, Sette, Claudio

“…The mitogen-activated protein kinase (MAPK) pathway is required for maintaining the chromatin condensed during the two meiotic divisions and to avoid a second…”
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Involvement of Phospholipase Cγ1 in Mouse Egg Activation Induced by a Truncated Form of the C-Kit Tyrosine Kinase Present in Spermatozoa by Sette, Claudio, Bevilacqua, Arturo, Geremia, Raffaele, Rossi, Pellegrino

“…Microinjection of a truncated form of the c-kit tyrosine kinase present in mouse spermatozoa (tr-kit) activates mouse eggs parthenogenetically, and…”
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The MAPK pathway triggers activation of Nek2 during chromosome condensation in mouse spermatocytes by Di Agostino, Silvia, Rossi, Pellegrino, Geremia, Raffaele, Sette, Claudio

“…Chromosome condensation during the G2/M progression of mouse pachytene spermatocytes induced by the phosphatase inhibitor okadaic acid (OA) requires the…”
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Differential Contribution of the MTOR and MNK Pathways to the Regulation of mRNA Translation in Meiotic and Postmeiotic Mouse Male Germ Cells1 by Messina, Valeria, Di Sauro, Annarita, Pedrotti, Simona, Adesso, Laura, Latina, Alessia, Geremia, Raffaele, Rossi, Pellegrino, Sette, Claudio

“…Translation of stored mRNAs accounts for protein synthesis during the transcriptionally inactive stages of spermatogenesis. A key step in mRNA translation is…”
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Parthenogenetic activation of mouse eggs by microinjection of a truncated c-kit tyrosine kinase present in spermatozoa by Sette, C, Bevilacqua, A, Bianchini, A, Mangia, F, Geremia, R, Rossi, P

“…A truncated form of the c-kit tyrosine kinase receptor, corresponding to the phosphotransferase portion of the cytoplasmic catalytic domain and the…”
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