Search Results - "Gerdt, Catherine"
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Epstein–Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation
Published in Proceedings of the National Academy of Sciences - PNAS (06-12-2016)“…Epstein–Barr virus (EBV) super-enhancers (ESEs) are essential for lymphoblastoid cell (LCL) growth and survival. Reanalyses of LCL global run-on sequencing…”
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A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth
Published in Nature communications (22-03-2023)“…Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and…”
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Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300
Published in Journal of virology (01-05-2018)“…Epstein-Barr virus nuclear antigen (EBNA) leader protein (EBNALP) is one of the first viral genes expressed upon B-cell infection. EBNALP is essential for…”
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CRISPR/Cas9-Mediated Genome Editing in Epstein-Barr Virus-Transformed Lymphoblastoid B-Cell Lines
Published in Current protocols in molecular biology (Print) (01-01-2018)“…Epstein-Barr virus (EBV) efficiently transforms primary human B cells into immortalized lymphoblastoid cell lines (LCLs), which are extensively used in human…”
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The Epstein-Barr Virus Regulome in Lymphoblastoid Cells
Published in Cell host & microbe (11-10-2017)“…Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell lines (LCLs), which represent an experimental model for…”
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Chemical factors induce aggregative multicellularity in a close unicellular relative of animals
Published in Proceedings of the National Academy of Sciences - PNAS (02-05-2023)“…Regulated cellular aggregation is an essential process for development and healing in many animal tissues. In some animals and a few distantly related…”
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Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes
Published in iScience (20-09-2024)“…Transmission of vector-borne diseases can be slowed by symbionts within the secondary hosts that spread disease. Snails spread schistosomiasis, and the snail…”
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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors
Published in SLAS discovery (01-01-2021)“…Hematopoietic progenitor kinase 1 (HPK1), also referred to as mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1), is a serine/threonine kinase…”
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Modulating Gene Expression in Epstein-Barr Virus (EBV)-Positive B Cell Lines with CRISPRa and CRISPRi
Published in Current protocols in molecular biology (Print) (16-01-2018)“…Epstein-Barr virus (EBV) transforms small resting primary B cells into large lymphoblastoid cells which are able to grow and survive in vitro indefinitely…”
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