Search Results - "Gerbier, Romain"

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions by Oishi, Atsuro, Karamitri, Angeliki, Gerbier, Romain, Lahuna, Olivier, Ahmad, Raise, Jockers, Ralf

“…Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug…”
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Apelin and Vasopressin: The Yin and Yang of Water Balance by Girault-Sotias, Pierre-Emmanuel, Gerbier, Romain, Flahault, Adrien, de Mota, Nadia, Llorens-Cortes, Catherine

“…Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling body fluid homeostasis and cardiovascular functions. Experimental data performed in…”
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Development of original metabolically stable apelin‐17 analogs with diuretic and cardiovascular effects by Gerbier, Romain, Alvear‐Perez, Rodrigo, Margathe, Jean‐Francois, Flahault, Adrien, Couvineau, Pierre, Gao, Ji, De Mota, Nadia, Dabire, Hubert, Li, Bo, Ceraudo, Emilie, Hus‐Citharel, Annette, Esteoulle, Lucie, Bisoo, Cynthia, Hibert, Marcel, Berdeaux, Alain, Iturrioz, Xavier, Bonnet, Dominique, Llorens‐Cortes, Catherine

“…ABSTRACT Apelin, a (neuro)vasoactive peptide, plays a prominent role in controlling cardiovascular functions and water balance. Because the in vivo apelin…”
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Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins by Chen, Min, Cecon, Erika, Karamitri, Angeliki, Gao, Wenwen, Gerbier, Romain, Ahmad, Raise, Jockers, Ralf

“…G protein‐coupled receptors (GPCRs) transmit extracellular signals into cells by activating G protein‐ and β‐arrestin‐dependent pathways. Extracellular…”
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Brain ACE2 activation following brain aminopeptidase A blockade by firibastat in salt-dependent hypertension by Hmazzou, Reda, Marc, Yannick, Flahault, Adrien, Gerbier, Romain, De Mota, Nadia, Llorens-Cortes, Catherine

“…In the brain, aminopeptidase A (APA), a membrane-bound zinc metalloprotease, generates angiotensin III from angiotensin II. Brain angiotensin III exerts a…”
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Pharmacological evidence for transactivation within melatonin MT2 and serotonin 5‐HT2C receptor heteromers in mouse brain by Gerbier, Romain, Ndiaye‐Lobry, Delphine, Martinez de Morentin, Pablo B., Cecon, Erika, Heisler, Lora K., Delagrange, Philippe, Gbahou, Florence, Jockers, Ralf

“…Association of G protein‐coupled receptors into heterodimeric complexes has been reported for over 50 receptor pairs in vitro but functional in vivo validation…”
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Melatonin MT 1 and MT 2 receptor ERK signaling is differentially dependent on G i/o and G q/11 proteins by Chen, Min, Cecon, Erika, Karamitri, Angeliki, Gao, Wenwen, Gerbier, Romain, Ahmad, Raise, Jockers, Ralf

“…G protein-coupled receptors (GPCRs) transmit extracellular signals into cells by activating G protein- and β-arrestin-dependent pathways. Extracellular…”
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LGR5 controls extracellular matrix production by stem cells in the developing intestine by Fernandez Vallone, Valeria, Leprovots, Morgane, Ribatallada‐Soriano, Didac, Gerbier, Romain, Lefort, Anne, Libert, Frédérick, Vassart, Gilbert, Garcia, Marie‐Isabelle

“…The Lgr5 receptor is a marker of intestinal stem cells (ISCs) that regulates Wnt/b‐catenin signaling. In this study, phenotype analysis of knockin/knockout…”
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LGR 5 controls extracellular matrix production by stem cells in the developing intestine by Fernandez Vallone, Valeria, Leprovots, Morgane, Ribatallada‐Soriano, Didac, Gerbier, Romain, Lefort, Anne, Libert, Frédérick, Vassart, Gilbert, Garcia, Marie‐Isabelle

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By interacting with the C-terminal Phe of apelin, Phe$^{255}$ and Trp$^{259}$ in helix VI of the apelin receptor are critical for internalization by Iturrioz, Xavier, Gerbier, Romain, Leroux, Vincent, Alvear-Perez, Rodrigo, Maigret, Bernard, Llorens-Cortes, Catherine

“…Apelin is the endogenous ligand of the orphan seven-transmembrane domain (TM) G protein-coupled receptor APJ. Apelin is involved in the regulation of body…”
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Design and validation of the first cell‐impermeant melatonin receptor agonist by Gbahou, Florence, Cecon, Erika, Viault, Guillaume, Gerbier, Romain, Jean‐Alphonse, Frederic, Karamitri, Angeliki, Guillaumet, Gérald, Delagrange, Philippe, Friedlander, Robert M, Vilardaga, Jean‐Pierre, Suzenet, Franck, Jockers, Ralf

“…Background and Purpose The paradigm that GPCRs are able to prolong or initiate cellular signalling through intracellular receptors recently emerged. Melatonin…”
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New structural insights into the apelin receptor: identification of key residues for apelin binding by Gerbier, Romain, Leroux, Vincent, Couvineau, Pierre, Alvear‐Perez, Rodrigo, Maigret, Bernard, Llorens‐Cortes, Catherine, Iturrioz, Xavier

“…Apelin is the endogenous ligand of the orphan 7‐transmembrane domain GPCRAPJ, now named the apelin receptor (ApelinR). Apelin plays a prominent role in body…”
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Pharmacological evidence for transactivation within melatonin MT 2 and serotonin 5-HT 2C receptor heteromers in mouse brain by Gerbier, Romain, Ndiaye-Lobry, Delphine, Martinez de Morentin, Pablo B, Cecon, Erika, Heisler, Lora K, Delagrange, Philippe, Gbahou, Florence, Jockers, Ralf

“…Association of G protein-coupled receptors into heterodimeric complexes has been reported for over 50 receptor pairs in vitro but functional in vivo validation…”
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Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist by Iturrioz, Xavier, Alvear-Perez, Rodrigo, De Mota, Nadia, Franchet, Christel, Guillier, Fabrice, Leroux, Vincent, Dabire, Hubert, Le Jouan, Melissande, Chabane, Hadjila, Gerbier, Romain, Bonnet, Dominique, Berdeaux, Alain, Maigret, Bernard, Galzi, Jean-Luc, Hibert, Marcel, Llorens-Cortes, Catherine

“…Apelin plays a prominent role in body fluid and cardiovascular homeostasis. To explore further upstream the role played by this peptide, nonpeptidic agonists…”
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O-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors by Karamitri, Angeliki, Sadek, Mirna S., Journé, Anne-Sophie, Gbahou, Florence, Gerbier, Romain, Osman, Mai B., Habib, Samy A.M., Jockers, Ralf, Zlotos, Darius P.

“…[Display omitted] •Bivalent ligands 3a-e increase BRET signals of MT1 dimers up to 3-fold vs. control 4.•3a-e do not change BRET signals at MT2 dimers compared…”
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Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT 2 receptor reciprocally modulate their signaling functions by Oishi, Atsuro, Karamitri, Angeliki, Gerbier, Romain, Lahuna, Olivier, Ahmad, Raise, Jockers, Ralf

“…Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug…”
Get full text

By Interacting with the C-terminal Phe of Apelin, Phe255 and Trp259 in Helix VI of the Apelin Receptor Are Critical for Internalization by Iturrioz, Xavier, Gerbier, Romain, Leroux, Vincent, Alvear-Perez, Rodrigo, Maigret, Bernard, Llorens-Cortes, Catherine

“…Apelin is the endogenous ligand of the orphan seven-transmembrane domain (TM) G protein-coupled receptor APJ. Apelin is involved in the regulation of body…”
Get full text