Search Results - "Gerberick, F"

Skin Sensitization Testing: The Ascendancy of Non-Animal Methods by Basketter, David A., Gerberick, George F.

“…A century ago, toxicology was an empirical science identifying substance hazards in surrogate mammalian models. Over several decades, these models improved,…”
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Identifying and characterizing chemical skin sensitizers without animal testing: Colipa’s research and method development program by Aeby, P., Ashikaga, T., Bessou-Touya, S., Schepky, A., Gerberick, F., Kern, P., Marrec-Fairley, M., Maxwell, G., Ovigne, J.-M., Sakaguchi, H., Reisinger, K., Tailhardat, M., Martinozzi-Teissier, S., Winkler, P.

“…The sensitizing potential of chemicals is usually identified and characterized using one of the available animal test methods, such as the mouse local lymph…”
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The local lymph node assay: past, present and future by Kimber, Ian, Dearman, R. J., Basketter, D. A., Ryan, C. A., Gerberick, G. F.

“…The local lymph node assay (LLNA) was developed originally as a method for the identification of chemicals that have the potential to cause skin sensitization…”
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Quantification of Chemical Peptide Reactivity for Screening Contact Allergens: A Classification Tree Model Approach by Gerberick, G. Frank, Vassallo, Jeffrey D., Foertsch, Leslie M., Price, Brad B., Chaney, Joel G., Lepoittevin, Jean-Pierre

“…In the interest of reducing animal use, in vitro alternatives for skin sensitization testing are under development. One unifying characteristic of chemical…”
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Local lymph node assay — validation, conduct and use in practice by Basketter, D.A., Evans, P., Fielder, R.J., Gerberick, G.F., Dearman, R.J., Kimber, I.

“…The validation of alternative methods is a relatively new activity in toxicology. The local lymph node assay (LLNA), a novel method for the identification of…”
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Use of the local lymph node assay for the estimation of relative contact allergenic potency by Basketter, D. A., Blaikie, L., Dearman, R. J., Kimber, I., Ryan, C. A., Gerberick, G. F., Harvey, P., Evans, P., White, I. R., Rycroft, R. J. G.

“…The effective toxicological evaluation of skin sensitization demands that potential contact allergens are identified and that the likely risks of sensitization…”
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Classification of contact allergens according to potency: proposals by Kimber, I, Basketter, D.A, Butler, M, Gamer, A, Garrigue, J.-L, Gerberick, G.F, Newsome, C, Steiling, W, Vohr, H.-W

“…It is clear that contact allergens vary substantially with regard to the relative potency with which they are able to induce skin sensitisation. Considerations…”
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The local lymph node assay in practice: a current regulatory perspective by Cockshott, A, Evans, P, Ryan, C A, Gerberick, G F, Betts, C J, Dearman, R J, Kimber, I, Basketter, D A

“…Following the formal acceptance of the local lymph node assay (LLNA) as an Organization for Economic Cooperation and Development (OECD) guideline in April…”
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The International EU/COLIPA In Vitro Phototoxicity Validation Study: Results of Phase II (Blind Trial). Part 1: The 3T3 NRU Phototoxicity Test by Spielmann, H., Balls, M., Dupuis, J., Pape, W.J., Pechovitch, G., de Silva, O., Holzhütter, H.-G., Clothier, R., Desolle, P., Gerberick, F., Liebsch, M., Lovell, W.W., Maurer, T., Pfannenbecker, U., Potthast, J.M., Csato, M., Sladowski, D., Steiling, W., Brantom, P.

“…To date, no standardized international guideline for the testing of chemicals for phototoxic potential has been accepted for regulatory purposes. In 1991, the…”
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Use of a B Cell Marker (B220) to Discriminate between Allergens and Irritants in the Local Lymph Node Assay by Gerberick, G. Frank, Cruse, Lynn W., Ryan, Cindy A., Hulette, Ben C., Chaney, Joel G., Skinner, Robert A., Dearman, Rebecca J., Kimber, Ian

“…It has been shown that exposure of mice to contact allergens induces B cell activation in the draining lymph nodes (DLN), as seen by an increase in the…”
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Skin sensitisation, vehicle effects and the local lymph node assay by Basketter, D.A, Gerberick, G.F, Kimber, I

“…Accurate risk assessment in allergic contact dermatitis is dependent on the successful prospective identification of chemicals which possess the ability to…”
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Examination of a vehicle for use with water soluble materials in the murine local lymph node assay by Ryan, C.A., Cruse, L.W., Skinner, R.A., Dearman, R.J., Kimber, I., Gerberick, G.F.

“…The murine local lymph node assay (LLNA) is a validated method for identifying skin sensitization hazard. Vehicle choice can influence the sensitization…”
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The local lymph node assay: A viable alternative to currently accepted skin sensitization tests by Basketter, D.A., Gerberick, G.F., Kimber, I., Loveless, S.E.

“…The prospective identification of skin sensitizing chemicals is a vital prerequisite for their proper risk management. Traditionally this has been achieved…”
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Thresholds in Contact Sensitization: Theoretical and Practical Considerations by Kimber, I, Gerberick, G.F, Basketter, D.A

“…The existence of thresholds for both the induction and the elicitation of contact sensitization is an important issue for hazard assessment in this area of…”
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Activity of human contact allergens in the murine local lymph node assay by Ryan, C. A., Gerberick, G. F., Cruse, L. W., Basketter, D. A., Lea, L., Blaikie, L., Dearman, R. J., Warbrick, E. V., Kimber, I.

“…The murine local lymph node assay (LLNA) is a predictive test for the identification of chemicals that have the potential to cause skin sensitization. Since…”
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Approaches for the development of cell-based in vitro methods for contact sensitization by Ryan, C.A., Hulette, B.C., Gerberick, G.F.

“…Allergic contact dermatitis (ACD) is a cell-mediated immune response to small molecular weight chemicals that contact and penetrate the skin. There are a…”
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Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin by Lavker, Robert M, Gerberick, G.Frank, Veres, Denise, Irwin, Chris J, Kaidbey, Kays H

“…Background : The skin is repeatedly exposed to solar UV radiation. Long-term photodamage is a consequence of cumulative UV radiation injury. Hence an…”
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Further evaluation of the local lymph node assay in the final phase of an international collaborative trial by Loveless, Scott E., Ladies, Gregory S., Gerberick, G.Frank, Ryan, Cindy A., Basketter, David A., Scholes, Edward W., House, Robert V., Hilton, Jennifer, Dearman, Rebecca J., Kimber, Ian

“…The local lymph node assay (LLNA) is a method used for the prospective identification in mice of chemicals that have the potential to cause skin sensitization…”
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The importance of exposure estimation in the assessment of skin sensitization risk by Robinson, Michael K., Gerberick, G. Frank, Ryan, Cindy A., McNamee, Pauline, White, Ian R., Basketter, David A.

“…The development of new ingredients and products for the consumer market requires a thorough assessment of their potential for skin sensitization and the…”
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Elucidating Changes in Surface Marker Expression of Dendritic Cells Following Chemical Allergen Treatment by Hulette, Ben C., Ryan, Cindy A., Gerberick, G.Frank

“…Dendritic cells (DC) are highly specialized antigen-presenting cells (APC) located in lymphoid and many nonlymphoid tissues, and Langerhans cells (LC), a…”
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