Search Results - "Gerashchenko, Tatiana"
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Brainstem transcriptomic changes in male Wistar rats after acute stress, comparing the use of duplex specific nuclease (DSN)
Published in Scientific reports (19-09-2024)“…In this work, we have analyzed the transcriptomic changes in the brainstem of male Wistar rats 2 h after an acute stress exposure. We performed duplex-specific…”
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Comparison of the Illumina NextSeq 2000 and GeneMind Genolab M sequencing platforms for spatial transcriptomics
Published in BMC genomics (07-03-2023)“…The Illumina sequencing systems demonstrate high efficiency and power and remain the most popular platforms. Platforms with similar throughput and quality…”
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Metastasis prevention: How to catch metastatic seeds
Published in Biochimica et biophysica acta. Reviews on cancer (01-05-2023)“…Despite considerable advances in the evolution of anticancer therapies, metastasis still remains the main cause of cancer mortality. Therefore, current…”
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Spatial Profile of Tumor Microenvironment in PD-L1-Negative and PD-L1-Positive Triple-Negative Breast Cancer
Published in International journal of molecular sciences (11-01-2023)“…The problem of finding more precise stratification criteria for identifying the cohort of patients who would obtain the maximum benefit from immunotherapy is…”
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Prognosis of Different Types of Non-Small Cell Lung Cancer Progression: Current State and Perspectives
Published in Cellular physiology and biochemistry (10-03-2021)“…Despite advances in diagnostics and therapy of non-small cell lung cancer (NSCLC), the problem of prognosis and prevention of tumor progression is still highly…”
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Markers of Cancer Cell Invasion: Are They Good Enough?
Published in Journal of clinical medicine (24-07-2019)“…Invasion, or directed migration of tumor cells into adjacent tissues, is one of the hallmarks of cancer and the first step towards metastasis. Penetrating to…”
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Premalignant Changes in the Bronchial Epithelium Are Prognostic Factors of Distant Metastasis in Non-Small Cell Lung Cancer Patients
Published in Frontiers in oncology (10-11-2021)“…The study assessed the possibility of dividing patients into groups based on the assessment of morphological changes in the epithelium of small-caliber bronchi…”
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Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis
Published in Immunobiology (1979) (01-04-2017)“…Abstract Recent studies have highlighted the heterogeneity of the tumor microenvironment (ME) and the importance of its analysis to the understanding of its…”
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Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression
Published in Scientific reports (16-04-2014)“…In this study, the influence of intratumoral morphological heterogeneity of breast cancer on neoadjuvant chemotherapy (NAC) efficiency was investigated. In…”
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Gene Expression Profiling Revealed 2 Types of Bronchial Basal Cell Hyperplasia and Squamous Metaplasia With Different Progression Potentials
Published in Applied immunohistochemistry & molecular morphology (01-07-2020)“…The premalignant process preceding squamous cell lung cancer is not inevitable; it can stop at any of the bronchial lesionsbasal cell hyperplasia (BCH),…”
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The Activity of KIF14, Mieap, and EZR in a New Type of the Invasive Component, Torpedo-Like Structures, Predetermines the Metastatic Potential of Breast Cancer
Published in Cancers (15-07-2020)“…Intratumor morphological heterogeneity reflects patterns of invasive growth and is an indicator of the metastatic potential of breast cancer. In this study, we…”
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Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44 + CD24 - stemness
Published in Oncotarget (22-09-2017)“…Intratumor morphological heterogeneity in breast cancer is represented by different morphological structures (tubular, alveolar, solid, trabecular, and…”
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Multi-omics of in vitro aortic valve calcification
Published in Frontiers in cardiovascular medicine (03-11-2022)“…Heart valve calcification is an active cellular and molecular process that partly remains unknown. Osteogenic differentiation of valve interstitial cells (VIC)…”
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Heterogeneity of Circulating Epithelial Cells in Breast Cancer at Single‐Cell Resolution: Identifying Tumor and Hybrid Cells
Published in Advanced biology (01-02-2023)“…Circulating tumor cells and hybrid cells formed by the fusion of tumor cells with normal cells are leading players in metastasis and have prognostic relevance…”
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Recurrence of squamous cell lung carcinoma is associated with the co-presence of reactive lesions in tumor-adjacent bronchial epithelium
Published in Tumor biology (01-03-2016)“…Recurrences occur in 30 % of lung cancer patients after radical therapy; however, known prognostic factors are not always effective. In this study, we…”
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Phenotypic drift as a cause for intratumoral morphological heterogeneity of invasive ductal breast carcinoma not otherwise specified
Published in BioResearch open access (01-04-2013)“…Invasive ductal carcinoma (IDC) not otherwise specified (NOS), the most common type of breast cancer, demonstrates great intratumoral morphological…”
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New Angiogenic Regulators Produced by TAMs: Perspective for Targeting Tumor Angiogenesis
Published in Cancers (29-06-2021)“…Angiogenesis is crucial to the supply of a growing tumor with nutrition and oxygen. Inhibition of angiogenesis is one of the main treatment strategies for…”
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Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer
Published in Gene (20-08-2024)“…Early prediction and prevention of recurring illness is critical for improving the survival rates of patients with non-small cell lung cancer (NSCLC)…”
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