Search Results - "Gerardo Guillén Nieto"

Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review by Berlanga-Acosta, Jorge, Guillén-Nieto, Gerardo, Rodríguez-Rodríguez, Nadia, Bringas-Vega, Maria Luisa, García-Del-Barco-Herrera, Diana, Berlanga-Saez, Jorge O, García-Ojalvo, Ariana, Valdés-Sosa, Mitchell Joseph, Valdés-Sosa, Pedro A

“…Insulin plays a major neuroprotective and trophic function for cerebral cell population, thus countering apoptosis, beta-amyloid toxicity, and oxidative…”
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The Nucleocapsid Protein of SARS-CoV-2, Combined with ODN-39M, Is a Potential Component for an Intranasal Bivalent Vaccine with Broader Functionality by Lobaina, Yadira, Chen, Rong, Suzarte, Edith, Ai, Panchao, Huerta, Vivian, Musacchio, Alexis, Silva, Ricardo, Tan, Changyuan, Martín, Alejandro, Lazo, Laura, Guillén-Nieto, Gerardo, Yang, Ke, Perera, Yasser, Hermida, Lisset

“…Despite the rapid development of vaccines against COVID-19, they have important limitations, such as safety issues, the scope of their efficacy, and the…”
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Intralesional Infiltrations of Arteriosclerotic Tissue Cells-Free Filtrate Reproduce Vascular Pathology in Healthy Recipient Rats by Berlanga-Acosta, Jorge, Fernández-Mayola, Maday, Mendoza-Marí, Yssel, García-Ojalvo, Ariana, Martinez-Jimenez, Indira, Rodriguez-Rodriguez, Nadia, Playford, Raymond J, Reyes-Acosta, Osvaldo, Lopez-Marín, Laura, Guillén-Nieto, Gerardo

“…Lower-extremity arterial disease is a major health problem with increasing prevalence, often leading to non-traumatic amputation, disability and mortality. The…”
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Preparing for the Next Pandemic: Increased Expression of Interferon-Stimulated Genes After Local Administration of Nasalferon or HeberNasvac by Aguiar Santiago, Jorge Agustín, Marrero Miragaya, Maria Acelia, Figueroa Oliva, Dariel Adrian, Aguilar Juanes, Andres, Idavoy Corona, Arletis, Martínez Fernández, Seknia, Morán Bertot, Ivis, Rodríguez Hernández, Meilyn, Canales López, Eduardo, Hernández Esteves, Ingrid, Silva Girado, José Angel, Estrada Vázquez, Regla Caridad, Gell Cuesta, Omar, Mendoza-Marí, Yssel, Valdés Prado, Iris, Rodríguez Ibarra, Chabeli, Palenzuela Gardon, Daniel Octavio, Pentón Arias, Eduardo, Guillén Nieto, Gerardo, Aguilar Rubido, Julio Cesar

“…HeberNasvac, a therapeutic vaccine for chronic hepatitis B, is able to safely stimulate multiple Toll-like receptors, increasing antigen presentation and in a…”
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Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis by Marín-Prida, Javier, Pavón-Fuentes, Nancy, Lagumersindez-Denis, Nielsen, Camacho-Rodríguez, Hanlet, García-Soca, Ana Margarita, Sarduy-Chávez, Rocío de la Caridad, Vieira, Érica Leandro Marciano, Carvalho-Tavares, Juliana, Falcón-Cama, Viviana, Fernández-Massó, Julio Raúl, Hernández-González, Ignacio, Martínez-Donato, Gillian, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Cytokines, demyelination and neuroaxonal degeneration in the central nervous system are pivotal elements implicated in the pathogenesis of multiple sclerosis…”
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The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome by Marín-Prida, Javier, Rodríguez-Ulloa, Arielis, Besada, Vladimir, Llopiz-Arzuaga, Alexey, Batista, Nathália Vieira, Hernández-González, Ignacio, Pavón-Fuentes, Nancy, Marciano Vieira, Érica Leandro, Falcón-Cama, Viviana, Acosta, Emilio F., Martínez-Donato, Gillian, Cervantes-Llanos, Majel, Lingfeng, Dai, González, Luis J., Fernández-Massó, Julio Raúl, Guillén-Nieto, Gerardo, Pentón-Arias, Eduardo, Amaral, Flávio Almeida, Teixeira, Mauro Martins, Pentón-Rol, Giselle

“…Introduction The antinociceptive and pharmacological activities of C-Phycocyanin (C-PC) and Phycocyanobilin (PCB) in the context of inflammatory arthritis…”
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Cuban Abdala vaccine: Effectiveness in preventing severe disease and death from COVID-19 in Havana, Cuba; A cohort study by Más-Bermejo, Pedro I., Dickinson-Meneses, Félix O., Almenares-Rodríguez, Kenia, Sánchez-Valdés, Lizet, Guinovart-Díaz, Raúl, Vidal-Ledo, María, Galbán-García, Enrique, Olivera-Nodarse, Yadira, Morgado-Vega, Isabel, Dueñas-Carrera, Santiago, Pujol, Merardo, Hernández-Bernal, Francisco, Limonta-Fernández, Miladys, Guillén-Nieto, Gerardo, Muzio-González, Verena L., Ayala-Ávila, Marta

“…COVID-19 vaccines have proven safe and efficacious in reducing severe illness and death. Cuban protein subunit vaccine Abdala has shown safety, tolerability…”
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Evaluation in Mice of the Immunogenicity of a Tetravalent Subunit Vaccine Candidate Against Dengue Virus Using Mucosal and Parenteral Immunization Routes by Lazo Vázquez, Laura, Gil González, Lázaro, Marcos López, Ernesto, Pérez Fuentes, Yusleidi, Cervetto de Armas, Lázaro, Brown Richards, Enma, Valdés Prado, Iris, Suzarte Portal, Edith, Cobas Acosta, Karem, Yaugel Novoa, Melyssa, Romero Fernández, Yaremis, Guillén Nieto, Gerardo, Hermida Cruz, Lisset

“…Our group has developed a subunit vaccine candidate against Dengue virus (DENV) based on two different viral regions, the domain III of the envelope protein…”
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Very Small Size Proteoliposomes (VSSP) and Montanide combination enhance the humoral immuno response in a GnRH based vaccine directed to prostate cancer by Aguilar, Franklin Fuentes, Barranco, Jesús Junco, Fuentes, Eddy Bover, Aguilera, Lesvia Calzada, Sáez, Yovisleydis Lopez, Santana, María Dolores Castro, Vázquez, Eulogio Pimentel, Baker, Roberto Basulto, Acosta, Osvaldo Reyes, Pérez, Hilda Garay, Nieto, Gerardo Guillén

“…Highlights ► Increasing antibody against GnRH will decrease testosterone levels. ► VSSP increase the immune humoral response.► Peptide administration without…”
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Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal of the Evidences Supporting Their Cytoprotective Effects by Berlanga-Acosta, Jorge, Abreu-Cruz, Angel, Barco Herrera, Diana García-del, Mendoza-Marí, Yssel, Rodríguez-Ulloa, Arielis, García-Ojalvo, Ariana, Falcón-Cama, Viviana, Hernández-Bernal, Francisco, Beichen, Qu, Guillén-Nieto, Gerardo

“…Background: Growth hormone-releasing peptides (GHRPs) constitute a group of small synthetic peptides that stimulate the growth hormone secretion and the…”
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Screening for immune response against Dengue virus in Vietnamese non‐human primates: implications for vaccine developers by Lazo Vázquez, Laura, Suzarte Portal, Edith, Castro Velazco, Jorge, Yen, Phuong, Dung, Le Trung, Gil González, Lázaro, Valdés Prado, Iris, Marcos López, Ernesto, Cobas Acosta, Karem, Hien, Nguyen Dang, Guillén Nieto, Gerardo, Hermida Cruz, Lisset

“…One of the major problems faced for the development of a vaccine against Dengue virus is the lack of a suitable animal model. Although non‐human primates do…”
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Comparison between nasopharyngeal swabs and saliva as reliable specimens for the diagnosis of SARS-CoV-2 by González-Losada, Cristobal, González-Lodeiro, Luis Gabriel, Beato Canfux, Abraham Ismael, Fernández, Julio Raúl, Camacho, Hamlet, Vazquez-Blomquist, Dania, Guillén Nieto, Gerardo Enrique

“…ABSTRACT Introduction: The SARS-CoV-2 virus is a positive-strand RNA virus. The virus can also be detected in many different specimens as throat swabs, nasal…”
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Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity by Berlanga-Acosta, Jorge A, Guillén-Nieto, Gerardo E, Rodríguez-Rodríguez, Nadia, Mendoza-Mari, Yssel, Bringas-Vega, Maria Luisa, Berlanga-Saez, Jorge O, García Del Barco Herrera, Diana, Martinez-Jimenez, Indira, Hernandez-Gutierrez, Sandra, Valdés-Sosa, Pedro A

“…Diabetes is constantly increasing at a rate that outpaces genetic variation and approaches to pandemic magnitude. Skin cells physiology and the cutaneous…”
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Revisiting Pleiotropic Effects of Type I Interferons: Rationale for Its Prophylactic and Therapeutic Use Against SARS-CoV-2 by Garcia-Del-Barco, Diana, Risco-Acevedo, Daniela, Berlanga-Acosta, Jorge, Martos-Benítez, Frank Daniel, Guillén-Nieto, Gerardo

“…The pandemic distribution of SARS-CoV-2 together with its particular feature of inactivating the interferon-based endogenous response and accordingly,…”
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A peptide derived from HSP60 reduces proinflammatory cytokines and soluble mediators: a therapeutic approach to inflammation by Domínguez-Horta, Maria Del Carmen, Serrano-Díaz, Anabel, Hernández-Cedeño, Mabel, Martínez-Donato, Gillian, Guillén-Nieto, Gerardo

“…Cytokines are secretion proteins that mediate and regulate immunity and inflammation. They are crucial in the progress of acute inflammatory diseases and…”
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Cell-Free Filtrates (CFF) as Vectors of a Transmissible Pathologic Tissue Memory Code: A Hypothetical and Narrative Review by Berlanga-Acosta, Jorge, Fernandez-Mayola, Maday, Mendoza-Mari, Yssel, Garcia-Ojalvo, Ariana, Martinez-Jimenez, Indira, Rodriguez-Rodriguez, Nadia, Garcia Del Barco Herrera, Diana, Guillén-Nieto, Gerardo

“…Cellular memory is a controversial concept representing the ability of cells to "write and memorize" stressful experiences via epigenetic operators. The…”
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Safety, tolerability, and immunogenicity of a SARS-CoV-2 recombinant spike RBD protein vaccine: A randomised, double-blind, placebo-controlled, phase 1-2 clinical trial (ABDALA Study) by Hernández-Bernal, Francisco, Ricardo-Cobas, Maria C., Martín-Bauta, Yenima, Navarro-Rodríguez, Zadis, Piñera-Martínez, Marjoris, Quintana-Guerra, Joel, Urrutia-Pérez, Karen, Urrutia-Pérez, Klaudia, Chávez-Chong, Cristina O., Azor-Hernández, Jorge L., Rodríguez-Reinoso, José L., Lobaina-Lambert, Leonardo, Colina-Ávila, Elizabeth, Bizet-Almeida, Jacqueline, Rodríguez-Nuviola, Jeniffer, del Valle-Piñera, Sergio, Ramírez-Domínguez, Mayara, Tablada-Ferreiro, Elisangela, Alonso-Valdés, Marel, Lemos-Pérez, Gilda, Guillén-Nieto, Gerardo E., Palenzuela-Díaz, Ariel, Noa-Romero, Enrique, Limonta-Fernández, Miladys, Fernández-Ávila, Juan M., Ali-Mros, Nabil A., del Toro-Lahera, Lianne, Remedios-Reyes, Rossana, Ayala-Ávila, Marta, Muzio-González, Verena L.

“…Multiple vaccine candidates against COVID-19 are currently being evaluated. We evaluate the safety and immunogenicity protein of a novel SARS-CoV-2 virus…”
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Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms by Berlanga-Acosta, Jorge, Cibrian, Danay, Valiente-Mustelier, Juan, Suárez-Alba, José, García-Ojalvo, Ariana, Falcón-Cama, Viviana, Jiang, Baohong, Wang, Linlin, Guillén-Nieto, Gerardo

“…Dilated cardiomyopathy (DCM) is a fatal myocardial condition with ventricular structural changes and functional deficits, leading to systolic dysfunction and…”
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Contrasting Timing of Virological Relapse After Discontinuation of Tenofovir or Entecavir in Hepatitis B e Antigen-Negative Patients by Höner Zu Siederdissen, Christoph, Hui, Aric Josun, Sukeepaisarnjaroen, Wattana, Tangkijvanich, Pisit, Su, Wei Wen, Nieto, Gerardo Enrique Guillén, Gineste, Paul, Nitcheu, Josianne, Crabé, Sandrine, Stepien, Sandrine, Manns, Michael P, Trépo, Christian, Wedemeyer, Heiner, Cornberg, Markus

“…Stopping long-term nucleos(t)ide analogue therapy increases hepatitis B virus (HBV) surface antigen (HBsAg) loss rates in HBV e antigen (HBeAg)-negative…”
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Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome by Fernández-Mayola, Maday, Pimentel-Vázquez, Eulogio, Urquiza-Rodríguez, Aleida, Kulikovsky, Moshe, Guillen Nieto, Gerardo E., García del Barco Herrera, Diana, Falcón‐Cama, Viviana, García-Ojalvo, Ariana, Mendoza-Marí, Yssel, Savigne-Gutiérrez, William, Valdés-Pérez, Calixto, Fernández-Montequín, José, Berlanga-Acosta, Jorge, Pérez-Saad, Héctor

“…Soon after epidermal growth factor (EGF) discovery, some in vivo models appeared demonstrating its property to enhance cutaneous wound healing. EGF was the…”
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