Search Results - "Gerardo E Guillén"

Cellular Senescence as the Pathogenic Hub of Diabetes-Related Wound Chronicity by Berlanga-Acosta, Jorge A, Guillén-Nieto, Gerardo E, Rodríguez-Rodríguez, Nadia, Mendoza-Mari, Yssel, Bringas-Vega, Maria Luisa, Berlanga-Saez, Jorge O, García Del Barco Herrera, Diana, Martinez-Jimenez, Indira, Hernandez-Gutierrez, Sandra, Valdés-Sosa, Pedro A

“…Diabetes is constantly increasing at a rate that outpaces genetic variation and approaches to pandemic magnitude. Skin cells physiology and the cutaneous…”
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Impact of the Route and Schedule of Immunization on the Serological and Virological Response of Chronic Hepatitis B Patients Treated with HeberNasvac by Freyre, Freya Milagros, Aguiar, Jorge A, Cinza, Zurina, Figueroa, Nelvis, Diaz, Pablo Arsenio, Muzio, Verena Lucila, Lemos, Gilda, Freyre, Giselle, Coizeau, Edelgis, Rodríguez, Chabeli, Pentón, Eduardo, Campos, Magalys, Santos, Iván Luis, Mahtab, Mamun Al, Akbar, Sheikh Mohammad Fazle, Guillen, Gerardo E, Aguilar, Julio Cesar

“…HeberNasvac is a recently developed therapeutic vaccine for chronic hepatitis B (CHB) administered by intranasal (IN) and subcutaneous (SC) routes in a 14…”
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Gradual reduction of testosterone using a gonadotropin-releasing hormone vaccination delays castration resistance in a prostate cancer model by Barranco, Jesús A. Junco, Millar, Robert P, Fuentes, Franklin, Bover, Eddy, Pimentel, Eulogio, Basulto, Roberto, Calzada, Lesvia, Morán, Rolando, Rodríguez, Ayni, Garay, Hilda, Reyes, Osvaldo, Castro, Maria D, Bringas, Ricardo, Arteaga, Niurka, Toudurí, Henio, Rabassa, Mauricio, Fernández, Yairis, Serradelo, Andrés, Hernández, Eduardo, Guillén, Gerardo E

“…In a previous study aimed to design a novel prostate cancer vaccine, the authors of the present study demonstrated the advantage of combining the adjuvants…”
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Combination therapy of Epidermal Growth Factor and Growth Hormone-Releasing Hexapeptide in acute ischemic stroke: a phase I/II non-blinded, randomized clinical trial by Hernández-Bernal, Francisco, Estenoz-García, Donner, Gutiérrez-Ronquillo, Juan H, Martín-Bauta, Yenima, Catasús-Álvarez, Karen, Gutiérrez-Castillo, Mario, Guevara-Rodríguez, Marbelys, Castro-Jeréz, Aliuska, Fuentes-González, Yoandra, Pinto-Cruz, Yulemis, Valenzuela-Silva, Carmen, Muzio-González, Verena L, Pérez-Saad, Héctor, Subirós-Martínez, Nelvys, Guillén-Nieto, Gerardo E, Garcia-Del-Barco-Herrera, Diana

“…This study tested the hypothesis that a neuroprotective combined therapy based on epidermal growth factor (EGF) and growth hormone-releasing hexapeptide…”
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Safety, tolerability, and immunogenicity of a SARS-CoV-2 recombinant spike RBD protein vaccine: A randomised, double-blind, placebo-controlled, phase 1-2 clinical trial (ABDALA Study) by Hernández-Bernal, Francisco, Ricardo-Cobas, Maria C., Martín-Bauta, Yenima, Navarro-Rodríguez, Zadis, Piñera-Martínez, Marjoris, Quintana-Guerra, Joel, Urrutia-Pérez, Karen, Urrutia-Pérez, Klaudia, Chávez-Chong, Cristina O., Azor-Hernández, Jorge L., Rodríguez-Reinoso, José L., Lobaina-Lambert, Leonardo, Colina-Ávila, Elizabeth, Bizet-Almeida, Jacqueline, Rodríguez-Nuviola, Jeniffer, del Valle-Piñera, Sergio, Ramírez-Domínguez, Mayara, Tablada-Ferreiro, Elisangela, Alonso-Valdés, Marel, Lemos-Pérez, Gilda, Guillén-Nieto, Gerardo E., Palenzuela-Díaz, Ariel, Noa-Romero, Enrique, Limonta-Fernández, Miladys, Fernández-Ávila, Juan M., Ali-Mros, Nabil A., del Toro-Lahera, Lianne, Remedios-Reyes, Rossana, Ayala-Ávila, Marta, Muzio-González, Verena L.

“…Multiple vaccine candidates against COVID-19 are currently being evaluated. We evaluate the safety and immunogenicity protein of a novel SARS-CoV-2 virus…”
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Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from rheumatoid arthritis patients by Santos Savio, Alicia, Machado Diaz, Ana Cecilia, Chico Capote, Araceli, Miranda Navarro, Jamilet, Rodríguez Alvarez, Yunier, Bringas Pérez, Ricardo, Estévez del Toro, Miguel, Guillen Nieto, Gerardo E

“…Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies…”
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Immunotherapy of prostate cancer in a murine model using a novel GnRH based vaccine candidate by Junco, Jesús A, Peschke, Peter, Zuna, Ivan, Ehemann, Volker, Fuentes, Franklin, Bover, Eddy, Pimentel, Eulogio, Basulto, Roberto, Reyes, Osvaldo, Calzada, Lesvia, Castro, María D, Arteaga, Niurka, López, Yovisleidis, Garay, Hilda, Hernández, Héctor, Bringas, Ricardo, Guillén, Gerardo E

“…Abstract Previous studies with gonadotrophin releasing hormone (GnRH/LHRH) vaccines have shown the usefulness of immunization against this hormone in prostate…”
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Proinflammatory Soluble Interleukin-15 Receptor Alpha Is Increased in Rheumatoid Arthritis by Machado Diaz, Ana Cecilia, Chico Capote, Araceli, Arrieta Aguero, Celia Aurora, Rodríguez Alvarez, Yunier, García del Barco Herrera, Diana, Estévez del Toro, Miguel, Guillen Nieto, Gerardo E., Santos Savio, Alicia

“…Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease in which many cytokines have been implicated. In particular, IL-15 is a cytokine involved…”
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Identification of a novel antitumor peptide based on the screening of an Ala-library derived from the LALF(32-51) region by Vallespi, Maribel G, Fernandez, Julio R, Torrens, Isis, Garcia, Isbel, Garay, Hilda, Mendoza, Osmani, Granadillo, Milaid, Falcon, Viviana, Acevedo, Boris, Ubieta, Raimundo, Guillen, Gerardo E, Reyes, Osvaldo

“…Novel therapeutic peptides are increasingly making their way into clinical application. The cationic and amphipathic properties of certain peptides allow them…”
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Identification of a novel antitumor peptide based on the screening of an Ala-library derived from the LALF32-51 region by Vallespi, Maribel G., Fernandez, Julio R., Torrens, Isis, Garcia, Isbel, Garay, Hilda, Mendoza, Osmani, Granadillo, Milaid, Falcon, Viviana, Acevedo, Boris, Ubieta, Raimundo, Guillen, Gerardo E., Reyes, Osvaldo

“…Novel therapeutic peptides are increasingly making their way into clinical application. The cationic and amphipathic properties of certain peptides allow them…”
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HeberNasvac, a Therapeutic Vaccine for Chronic Hepatitis B, Stimulates Local and Systemic Markers of Innate Immunity: Potential Use in SARS-CoV-2 Postexposure Prophylaxis by Fleites, Yoel A, Aguiar, Jorge, Cinza, Zurina, Bequet, Monica, Marrero, Elieser, Vizcaíno, Maritania, Esquivel, Idelsis, Diaz, Marisol, Sin-Mayor, Adriana, Garcia, Maura, Martinez, Sara M, Beato, Abrahan, Galarraga, Ana G, Mendoza-Mari, Yssel, Valdés, Iris, García, Gerardo, Lemos, Gilda, González, Isabel, Canaán-Haden, Camila, Figueroa, Nelvis, Oquendo, Rachel, Akbar, Sheikh Mf, Mahtab, Mamun A, Uddin, Mohammad H, Guillén, Gerardo E, Muzio, Verena L, Pentón, Eduardo, Aguilar, Julio C

“…More than 180 million people have been infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and more than 4 million coronavirus…”
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A modified variant of human Interleukin-15 as a novel antigen for active immunotherapy in rheumatoid arthritis by Yunier Rodríguez, Alicia Santos, Yanelys Morera, Haydee Gerónimo, Jorge Castro, Rafael Martínez, Pedro Puente, Celia A Arrieta, Ricardo Silva, Alejandro Moro, Silvio E Perea, Klaudia Martínez, Yassel Ramos, Vladimir Besada, Alexey Llopiz, Eugenio Hardy, Mariela Vázquez, Gerardo E Guillén

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Glucose Toxic Effects on Granulation Tissue Productive Cells: The Diabetics’ Impaired Healing by García-Siverio, Marianela, Guillen Nieto, Gerardo E., López-Mola, Ernesto, Schultz, Gregory S., Berlanga-Acosta, Jorge, Herrera-Martinez, Luis

“…Type 2 diabetes mellitus is a metabolic noncommunicable disease with an expanding pandemic magnitude. Diabetes predisposes to lower extremities ulceration and…”
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Diabetic Foot Ulcers and Epidermal Growth Factor: Revisiting the Local Delivery Route for a Successful Outcome by Fernández-Mayola, Maday, Pimentel-Vázquez, Eulogio, Urquiza-Rodríguez, Aleida, Kulikovsky, Moshe, Guillen Nieto, Gerardo E., García del Barco Herrera, Diana, Falcón‐Cama, Viviana, García-Ojalvo, Ariana, Mendoza-Marí, Yssel, Savigne-Gutiérrez, William, Valdés-Pérez, Calixto, Fernández-Montequín, José, Berlanga-Acosta, Jorge, Pérez-Saad, Héctor

“…Soon after epidermal growth factor (EGF) discovery, some in vivo models appeared demonstrating its property to enhance cutaneous wound healing. EGF was the…”
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Identification of a novel antitumor peptide based on the screening of an Ala‐library derived from the LALF 32–51 region by Vallespi, Maribel G., Fernandez, Julio R., Torrens, Isis, Garcia, Isbel, Garay, Hilda, Mendoza, Osmani, Granadillo, Milaid, Falcon, Viviana, Acevedo, Boris, Ubieta, Raimundo, Guillen, Gerardo E., Reyes, Osvaldo

“…Abstract Novel therapeutic peptides are increasingly making their way into clinical application. The cationic and amphipathic properties of certain peptides…”
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Recombinant hybrid proteins from pertactin type 1 and 2 of Bordetella pertussis are more immunogenic in mice than the original molecules by Diógenes Quintana-Vázquez, Edelgis Coizeau, Anabel Alvarez, Maité Delgado, Tania Cárdenas, Yassel Ramos, Glay Chinea, Guy A M Berbers, Gerardo E Guillén

“…The present study explores the concept of hybrid pertactin (PRN) molecules for immunizing against Bordetella pertussis. New molecules were designed using an…”
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Protective immune response against Neisseria meningitidis serogroup B after immunization with peptides mimicking a capsular polysaccharide epitope by Tamara Menéndez, Hilda E Garay, Osvaldo Reyes, Yoelys Cruz, Edelgis Coizeau, Nelson F Santiago, Glay Chinea, Karem Cobas, Evelyn Caballero, Vivian Morera, Jesús Noda, Tania Carmenate, Yordanka Soria, Emma Brown, Alejandro Martín, Daniel Yero, Sonia González, Gerardo E Guillén

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Effect of human epidermal growth factor on the tumor cell line A431: in vivo analysis of tumor growth inhibition and gene expression by Isabel A Guillén, Hanlet Camacho, Maria E Fernández, Daniel O Palenzuela, Lincidio Pérez, Maria E Ochagavia, Julio Ancizar, Angela Tuero, Laritza Gorovaya, Osmani Mendoza, Tamara Díaz, Julio R Fernández, Juan Roca, Karelia Cosme, Gerardo E Guillén-Nieto, Luis Herrera, Jorge Berlanga, Lidia I Novoa

“…The historical tag of the epidermal growth factor (EGF) as carcinogenesis promoter has not been uniformly reproduced, since, in some experiments, malignant…”
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Growth Hormone Releasing Peptide 6 (GHRP6) reduces liver fibrosis in CCl4 chronically intoxicated rats by Jorge Berlanga-Acosta, Dania Vázquez-Blomquist, Danay Cibrián, Yssel Mendoza, María E Ochagavía, Jamilet Miranda, José Suárez, Yolanda González-Ferrer, José M Vila, Angel Abreu, Dayana Ugarte-Moreno, Yolanda Cruz, Ivon Howland, Rosa Coro-Antich, Olga S León, Ricardo Bringas, Diana García del Barco, Karelia Cosme-Díaz, Daniel Palenzuela, Julio R Fernández, Marcelo Nazabal, Isabel Guillén, Alberto Cintado, Lidia Inés, Ernesto López-Mola, Gerardo E Guillén-Nieto

“…Tissue fibrosis is a leading cause of morbidity and mortality. Current treatments for conditions such as hepatic fibrosis have been unsuccessful. The growth…”
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Molecular mechanisms involved in the inhibition of tumor cells proliferation exposed to elevated concentrations of the epidermal growth factor by Isabel A Guillén, Jorge Berlanga, Hanlet Camacho, María E Fernández-de-Cossio, Lincidio Pérez, Lidia I Novoa, Daniel O Palenzuela, Tamara Díaz, Gerardo E Guillén, Luis Herrera, Karelia Cosme, Laritza Gorovaya, Osmani Mendoza, Julio R Fernández, Julio A Ancizar, Jose Suarez, Ángela D Tuero, María E Ochagavía, Juan Roca, Jorge Gavilondo, Diana García del Barco, Jorge Martín

“…The EGF promotes inhibition of cell proliferation in vitro and in vivo models depending on its concentration, application schema and the type of tumor cells on…”
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