Search Results - "Gerard O’Sullivan, M."

PVT1 dependence in cancer with MYC copy-number increase by Tseng, Yuen-Yi, Moriarity, Branden S., Gong, Wuming, Akiyama, Ryutaro, Tiwari, Ashutosh, Kawakami, Hiroko, Ronning, Peter, Reuland, Brian, Guenther, Kacey, Beadnell, Thomas C., Essig, Jaclyn, Otto, George M., O’Sullivan, M. Gerard, Largaespada, David A., Schwertfeger, Kathryn L., Marahrens, York, Kawakami, Yasuhiko, Bagchi, Anindya

“…Pvt1 overexpression in mice contributes to high Myc levels due to 8q24.21 gain and to MYC-driven tumorigenesis. An RNA tied to MYC-driven cancers Many cancer…”
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A Highly Efficacious PS Gene Editing System Corrects Metabolic and Neurological Complications of Mucopolysaccharidosis Type I by Ou, Li, Przybilla, Michael J., Ahlat, Ozan, Kim, Sarah, Overn, Paula, Jarnes, Jeanine, O’Sullivan, M. Gerard, Whitley, Chester B.

“…Our previous study delivered zinc finger nucleases to treat mice with mucopolysaccharidosis type I (MPS I), resulting in a phase I/II clinical trial…”
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Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma by Pant, Kishor, Peixoto, Estanislao, Richard, Seth, Biswas, Aalekhya, O’Sullivan, M. Gerard, Giama, Nasra, Ha, Yeonjung, Yin, Jun, Carotenuto, Pietro, Salati, Massimiliano, Ren, Yanan, Yang, Rendong, Franco, Brunella, Roberts, Lewis R., Gradilone, Sergio A.

“…Background and Aims Sirtuin 1 (SIRT1) is a complex NAD+‐dependent protein deacetylase known to act as a tumor promoter or suppressor in different cancers…”
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CD4+ T cell anergy prevents autoimmunity and generates regulatory T cell precursors by Kalekar, Lokesh A, Schmiel, Shirdi E, Nandiwada, Sarada L, Lam, Wing Y, Barsness, Laura O, Zhang, Na, Stritesky, Gretta L, Malhotra, Deepali, Pauken, Kristen E, Linehan, Jonathan L, O'Sullivan, M Gerard, Fife, Brian T, Hogquist, Kristin A, Jenkins, Marc K, Mueller, Daniel L

“…T cell anergy is a well-established phenomenon, but its physiological role is unclear. Mueller and colleagues demonstrate that anergic self-reactive T cells…”
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Prognostic histopathologic features of canine glial tumors by Merickel, Joshua L., Pluhar, G. Elizabeth, Rendahl, Aaron, O’Sullivan, M. Gerard

“…Gliomas are relatively common tumors in aged dogs (especially brachycephalic breeds), and the dog is proving to be useful as a translational model for humans…”
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Meningioma with rhabdoid features: Pathologic findings in dogs by Tabaran, Alexandru-Flaviu, Armien, Anibal G., Pluhar, G. Elizabeth, O’Sullivan, M. Gerard

“…Rhabdoid meningioma is a rare type of meningeal neoplasm in humans. This study reports the clinical, pathological, and ultrastructural features of 4 cases of…”
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Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats by Balbo, Silvia, Johnson, Charles S, Kovi, Ramesh C, James-Yi, Sandra A, O'Sullivan, M Gerard, Wang, Mingyao, Le, Chap T, Khariwala, Samir S, Upadhyaya, Pramod, Hecht, Stephen S

“…4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolized to enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), found in the urine…”
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Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer by Starr, Timothy K, Allaei, Raha, Silverstein, Kevin A.T, Staggs, Rodney A, Sarver, Aaron L, Bergemann, Tracy L, Gupta, Mihir, O'Sullivan, M. Gerard, Matise, Ilze, Dupuy, Adam J, Collier, Lara S, Powers, Scott, Oberg, Ann L, Asmann, Yan W, Thibodeau, Stephen N, Tessarollo, Lino, Copeland, Neal G, Jenkins, Nancy A, Cormier, Robert T, Largaespada, David A

“…Human colorectal cancers (CRCs) display a large number of genetic and epigenetic alterations, some of which are causally involved in tumorigenesis (drivers)…”
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Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice by Hu, Qi, Corral, Pedro, Narayanapillai, Sreekanth C, Leitzman, Pablo, Upadhyaya, Pramod, O'Sullivan, M. Gerard, Hecht, Stephen S, Lu, Junxuan, Xing, Chengguo

“…Our early studies demonstrated an impressive chemopreventive efficacy of dihydromethysticin (DHM), unique in kava, against tobacco carcinogen…”
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Contribution of the innate and adaptive immune systems to aortic dilation in murine mucopolysaccharidosis type I by Braunlin, Elizabeth, Abrahante, Juan E., McElmurry, Ron, Evans, Michael, Smith, Miles, Seelig, Davis, O'Sullivan, M. Gerard, Tolar, Jakub, Whitley, Chester B., McIvor, R. Scott

“…Adult immunocompetent male C57Bl/6 mucopolysaccharidosis, type I (MPSI) mice develop aortic insufficiency (AI), dilated ascending aortas and decreased cardiac…”
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Diffusion Limited Cryopreservation of Tissue with Radiofrequency Heated Metal Forms by Han, Zonghu, Sharma, Anirudh, Gao, Zhe, Carlson, Timothy W., O'Sullivan, M. Gerard, Finger, Erik B., Bischof, John C.

“…Cryopreserved tissues are increasingly needed in biomedical applications. However, successful cryopreservation is generally only reported for thin tissues…”
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Flavokawains A and B in Kava, Not Dihydromethysticin, Potentiate Acetaminophen-Induced Hepatotoxicity in C57BL/6 Mice by Narayanapillai, Sreekanth C, Leitzman, Pablo, O’Sullivan, M. Gerard, Xing, Chengguo

“…Anxiolytic kava products have been associated with rare but severe hepatotoxicity in humans. This adverse potential has never been captured in animal models,…”
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Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice by Narayanapillai, Sreekanth C, Balbo, Silvia, Leitzman, Pablo, Grill, Alex E, Upadhyaya, Pramod, Shaik, Ahmad Ali, Zhou, Bo, O'Sullivan, M Gerard, Peterson, Lisa A, Lu, Junxuan, Hecht, Stephen S, Xing, Chengguo

“…We have previously shown that kava and its flavokavain-free Fraction B completely blocked 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung…”
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Inhaled Furan Selectively Damages Club Cells in Lungs of A/J Mice by Tǎbǎran, Alexandru-Flaviu, O’Sullivan, M. Gerard, Seabloom, Donna E., Vevang, Karin R., Smith, William E., Wiedmann, Timothy S., Peterson, Lisa A.

“…Furan, a possible human carcinogen, is a product of incomplete combustion and is present in cigarette smoke, engine exhaust, and processed food. Oral…”
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Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4‑Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung by Peterson, Lisa A, Oram, Marissa K, Flavin, Monica, Seabloom, Donna, Smith, William E, O’Sullivan, M. Gerard, Vevang, Karin R, Upadhyaya, Pramod, Stornetta, Alessia, Floeder, Andrew C, Ho, Yen-Yi, Zhang, Lin, Hecht, Stephen S, Balbo, Silvia, Wiedmann, Timothy S

“…Tobacco smoke is a complex mixture of chemicals, many of which are toxic and carcinogenic. Hazard assessments of tobacco smoke exposure have predominantly…”
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ssDNA nanotubes for selective targeting of glioblastoma and delivery of doxorubicin for enhanced survival by Harris, Michael A, Kuang, Huihui, Schneiderman, Zachary, Shiao, Maple L, Crane, Andrew T, Chrostek, Matthew R, Tăbăran, Alexandru-Flaviu, Pengo, Thomas, Liaw, Kevin, Xu, Beibei, Lin, Lucy, Chen, Clark C, O'Sullivan, M Gerard, Kannan, Rangaramanujam M, Low, Walter C, Kokkoli, Efrosini

“…Effective treatment of glioblastoma remains a daunting challenge. One of the major hurdles in the development of therapeutics is their inability to cross the…”
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Aberrant Retinoblastoma (RB)-E2F Transcriptional Regulation Defines Molecular Phenotypes of Osteosarcoma by Scott, Milcah C., Sarver, Aaron L., Tomiyasu, Hirotaka, Cornax, Ingrid, Van Etten, Jamie, Varshney, Jyotika, O'Sullivan, M. Gerard, Subramanian, Subbaya, Modiano, Jaime F.

“…We previously identified two distinct molecular subtypes of osteosarcoma through gene expression profiling. These subtypes are associated with distinct tumor…”
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Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation by Lynn, Geoffrey E, Burkhardt, Nicole Y, Felsheim, Roderick F, Nelson, Curtis M, Oliver, Jonathan D, Kurtti, Timothy J, Cornax, Ingrid, O'Sullivan, M Gerard, Munderloh, Ulrike G

“…subsp. is recognized as the etiological agent of human ehrlichiosis in Minnesota and Wisconsin. We describe the culture isolation of this organism from a…”
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Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor by Dorr, Casey, Janik, Callie, Weg, Madison, Been, Raha A, Bader, Justin, Kang, Ryan, Ng, Brandon, Foran, Lindsey, Landman, Sean R, O'Sullivan, M Gerard, Steinbach, Michael, Sarver, Aaron L, Silverstein, Kevin A T, Largaespada, David A, Starr, Timothy K

“…Non-small cell lung cancers (NSCLC) harbor thousands of passenger events that hide genetic drivers. Even highly recurrent events in NSCLC, such as mutations in…”
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Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma by Marko, Tracy A., Shamsan, Ghaidan A., Edwards, Elizabeth N., Hazelton, Paige E., Rathe, Susan K., Cornax, Ingrid, Overn, Paula R., Varshney, Jyotika, Diessner, Brandon J., Moriarity, Branden S., O’Sullivan, M. Gerard, Odde, David J., Largaespada, David A.

“…Osteosarcoma is the most common primary bone tumor, with metastatic disease responsible for most treatment failure and patient death. A forward genetic screen…”
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