Search Results - "Gerard Clarke"

Systemic Inflammation Persists the First Year after Mild Traumatic Brain Injury: Results from the Prospective Trondheim Mild Traumatic Brain Injury Study by Chaban, Viktoriia, Clarke, Gerard J B, Skandsen, Toril, Islam, Rakibul, Einarsen, Cathrine E, Vik, Anne, Damås, Jan K, Mollnes, Tom E, Håberg, Asta K, Pischke, Soeren E

“…Innate immune activation has been attributed a key role in traumatic brain injury (TBI) and successive morbidity. In mild TBI (mTBI), however, the extent and…”
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The blood-brain barrier in aging and neurodegeneration by Knox, Emily G., Aburto, Maria R., Clarke, Gerard, Cryan, John F., O’Driscoll, Caitriona M.

“…The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the…”
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Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice by Burokas, Aurelijus, Arboleya, Silvia, Moloney, Rachel D, Peterson, Veronica L, Murphy, Kiera, Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G, Cryan, John F

“…Abstract Background The realization that the microbiota-gut-brain axis plays a critical role in health and disease, including neuropsychiatric disorders, is…”
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Microbiota-Gut-Brain Axis: New Therapeutic Opportunities by Long-Smith, Caitríona, O'Riordan, Kenneth J, Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G, Cryan, John F

“…The traditional fields of pharmacology and toxicology are beginning to consider the substantial impact our gut microbiota has on host physiology. The…”
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Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions by Clarke, Gerard, Sandhu, Kiran V, Griffin, Brendan T, Dinan, Timothy G, Cryan, John F, Hyland, Niall P

“…The microbiome plays a key role in health and disease, and there has been considerable interest in therapeutic targeting of the microbiome as well as mining…”
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The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? by Stilling, Roman M., van de Wouw, Marcel, Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G., Cryan, John F.

“…Several lines of evidence suggest that brain function and behaviour are influenced by microbial metabolites. Key products of the microbiota are short-chain…”
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Minireview: Gut Microbiota: The Neglected Endocrine Organ by Clarke, Gerard, Stilling, Roman M, Kennedy, Paul J, Stanton, Catherine, Cryan, John F, Dinan, Timothy G

“…The concept that the gut microbiota serves as a virtual endocrine organ arises from a number of important observations. Evidence for a direct role arises from…”
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The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems by Flandroy, Lucette, Poutahidis, Theofilos, Berg, Gabriele, Clarke, Gerard, Dao, Maria-Carlota, Decaestecker, Ellen, Furman, Eeva, Haahtela, Tari, Massart, Sébastien, Plovier, Hubert, Sanz, Yolanda, Rook, Graham

“…Plants, animals and humans, are colonized by microorganisms (microbiota) and transiently exposed to countless others. The microbiota affects the development…”
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Gut microbiome patterns depending on children’s psychosocial stress: Reports versus biomarkers by Michels, Nathalie, Van de Wiele, Tom, Fouhy, Fiona, O'Mahony, Siobhain, Clarke, Gerard, Keane, James

“…•Children’s stress was cross-sectionally related to gut microbial composition.•New was the use of hair cortisol, heart rate variability and positive…”
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The role of the gut microbiome in the development of schizophrenia by Kelly, John R., Minuto, Chiara, Cryan, John F., Clarke, Gerard, Dinan, Timothy G.

“…Schizophrenia is a heterogeneous neurodevelopmental disorder involving the convergence of a complex and dynamic bidirectional interaction of genetic expression…”
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Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat by Kelly, John R, Borre, Yuliya, O' Brien, Ciaran, Patterson, Elaine, el Aidy, Sahar, Deane, Jennifer, Kennedy, Paul J, Beers, Sasja, Scott, Karen, Moloney, Gerard, Hoban, Alan E, Scott, Lucinda, Fitzgerald, Patrick, Ross, Paul, Stanton, Catherine, Clarke, Gerard, Cryan, John F, Dinan, Timothy G

“…Abstract The gut microbiota interacts with the host via neuroimmune, neuroendocrine and neural pathways. These pathways are components of the…”
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Adult microbiota-deficient mice have distinct dendritic morphological changes: differential effects in the amygdala and hippocampus by Luczynski, Pauline, Whelan, Seán O., O'Sullivan, Colette, Clarke, Gerard, Shanahan, Fergus, Dinan, Timothy G., Cryan, John F.

“…Increasing evidence implicates the microbiota in the regulation of brain and behaviour. Germ‐free mice (GF; microbiota deficient from birth) exhibit altered…”
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Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease by Codagnone, Martin G., Spichak, Simon, O’Mahony, Siobhain M., O’Leary, Olivia F., Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G., Cryan, John F.

“…It has been nearly 30 years since Dr. David Barker first highlighted the importance of prenatal factors in contributing to the developmental origins of adult…”
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Biological and psychological markers of stress in humans: Focus on the Trier Social Stress Test by ALLEN, Andrew P, KENNEDY, Paul J, CRYAN, John F, DINAN, Timothy G, CLARKE, Gerard

“…Validated biological and psychological markers of acute stress in humans are an important tool in translational research. The Trier Social Stress Test (TSST),…”
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Cross Talk: The Microbiota and Neurodevelopmental Disorders by Kelly, John R, Minuto, Chiara, Cryan, John F, Clarke, Gerard, Dinan, Timothy G

“…Humans evolved within a microbial ecosystem resulting in an interlinked physiology. The gut microbiota can signal to the brain via the immune system, the vagus…”
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Irritable bowel syndrome: A microbiome-gut-brain axis disorder? by Kennedy, Paul J, Cryan, John F, Dinan, Timothy G, Clarke, Gerard

“…Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to…”
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The probiotic Bifidobacteria infantis : An assessment of potential antidepressant properties in the rat by Desbonnet, Lieve, Garrett, Lillian, Clarke, Gerard, Bienenstock, John, Dinan, Timothy G

“…Abstract It is becoming increasingly apparent that probiotics are important to the health of the host. The absence of probiotic bacteria in the gut can have…”
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Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease by Spichak, Simon, Bastiaanssen, Thomaz F.S., Berding, Kirsten, Vlckova, Klara, Clarke, Gerard, Dinan, Timothy G., Cryan, John F.

“…Dietary fibres, proteins and fats that are ingested by the host contain components which are metabolized by the host microbiota. Short-chain fatty acids…”
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The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies by Marx, Wolfgang, McGuinness, Amelia J., Rocks, Tetyana, Ruusunen, Anu, Cleminson, Jasmine, Walker, Adam J., Gomes-da-Costa, Susana, Lane, Melissa, Sanches, Marsal, Diaz, Alexandre P., Tseng, Ping-Tao, Lin, Pao-Yen, Berk, Michael, Clarke, Gerard, O’Neil, Adrienne, Jacka, Felice, Stubbs, Brendon, Carvalho, André F., Quevedo, João, Soares, Jair C., Fernandes, Brisa S.

“…The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and…”
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Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders by Kelly, John R, Kennedy, Paul J, Cryan, John F, Dinan, Timothy G, Clarke, Gerard, Hyland, Niall P

“…The emerging links between our gut microbiome and the central nervous system (CNS) are regarded as a paradigm shift in neuroscience with possible implications…”
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