Search Results - "Gerard, I."

The Value of Democracy: Evidence from Road Building in Kenya by Burgess, Robin, Jedwab, Remi, Miguel, Edward, Morjaria, Ameet, Padró i Miquel, Gerard

“…Ethnic favoritism is seen as antithetical to development. This paper provides credible quantification of the extent of ethnic favoritism using data on road…”
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Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma by Hall, Zoe, Chiarugi, Davide, Charidemou, Evelina, Leslie, Jack, Scott, Emma, Pellegrinet, Luca, Allison, Michael, Mocciaro, Gabriele, Anstee, Quentin M., Evan, Gerard I., Hoare, Matthew, Vidal‐Puig, Antonio, Oakley, Fiona, Vacca, Michele, Griffin, Julian L.

“…Background and Aims Hepatocytes undergo profound metabolic rewiring when primed to proliferate during compensatory regeneration and in hepatocellular carcinoma…”
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Distinct Thresholds Govern Myc's Biological Output In Vivo by Murphy, Daniel J., Junttila, Melissa R., Pouyet, Laurent, Karnezis, Anthony, Shchors, Ksenya, Bui, Duyen A., Brown-Swigart, Lamorna, Johnson, Leisa, Evan, Gerard I.

“…Deregulated Myc triggers a variety of intrinsic tumor suppressor programs that serve to restrain Myc's oncogenic potential. Since Myc activity is also required…”
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The ups and downs of Myc biology by Soucek, Laura, Evan, Gerard I

“…The basic helix–loop–helix protein Myc is a renowned transcription factor controlling disparate aspects of cell physiology that, together, allow efficient…”
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Modeling the Therapeutic Efficacy of p53 Restoration in Tumors by Martins, Carla P., Brown-Swigart, Lamorna, Evan, Gerard I.

“…Although restoration of p53 function is an attractive tumor-specific therapeutic strategy, it remains unclear whether p53 loss is required only for transition…”
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p53 - a Jack of all trades but master of none by Evan, Gerard I, Junttila, Melissa R

“…Key Points p53 is an evolutionary ancient transcription factor, the primordial function of which in early metazoans may have been to coordinate transcriptional…”
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Myc Cooperates with Ras by Programming Inflammation and Immune Suppression by Kortlever, Roderik M., Sodir, Nicole M., Wilson, Catherine H., Burkhart, Deborah L., Pellegrinet, Luca, Brown Swigart, Lamorna, Littlewood, Trevor D., Evan, Gerard I.

“…The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven…”
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MYC Instructs and Maintains Pancreatic Adenocarcinoma Phenotype by Sodir, Nicole M, Kortlever, Roderik M, Barthet, Valentin J A, Campos, Tania, Pellegrinet, Luca, Kupczak, Steven, Anastasiou, Panayiotis, Swigart, Lamorna Brown, Soucek, Laura, Arends, Mark J, Littlewood, Trevor D, Evan, Gerard I

“…The signature features of pancreatic ductal adenocarcinoma (PDAC) are its fibroinflammatory stroma, poor immune activity, and dismal prognosis. We show that…”
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Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology by Pello, Oscar M., De Pizzol, Maria, Mirolo, Massimiliano, Soucek, Laura, Zammataro, Luca, Amabile, Angelo, Doni, Andrea, Nebuloni, Manuela, Swigart, Lamorna B., Evan, Gerard I., Mantovani, Alberto, Locati, Massimo

“…In response to microenvironmental signals, macrophages undergo different activation, including the “classic” proinflammatory phenotype (also called M1), the…”
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Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice by Soucek, Laura, Whitfield, Jonathan R, Sodir, Nicole M, Massó-Vallés, Daniel, Serrano, Erika, Karnezis, Anthony N, Swigart, Lamorna Brown, Evan, Gerard I

“…The principal reason for failure of targeted cancer therapies is the emergence of resistant clones that regenerate the tumor. Therapeutic efficacy therefore…”
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A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer by von Eyss, Björn, Jaenicke, Laura A., Kortlever, Roderik M., Royla, Nadine, Wiese, Katrin E., Letschert, Sebastian, McDuffus, Leigh-Anne, Sauer, Markus, Rosenwald, Andreas, Evan, Gerard I., Kempa, Stefan, Eilers, Martin

“…In several developmental lineages, an increase in MYC expression drives the transition from quiescent stem cells to transit-amplifying cells. We show that MYC…”
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Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity by Bywater, Megan J., Burkhart, Deborah L., Straube, Jasmin, Sabò, Arianna, Pendino, Vera, Hudson, James E., Quaife-Ryan, Gregory A., Porrello, Enzo R., Rae, James, Parton, Robert G., Kress, Theresia R., Amati, Bruno, Littlewood, Trevor D., Evan, Gerard I., Wilson, Catherine H.

“…It is unclear why some tissues are refractory to the mitogenic effects of the oncogene Myc. Here we show that Myc activation induces rapid transcriptional…”
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Re-engineering the Pancreas Tumor Microenvironment: A "Regenerative Program" Hacked by Evan, Gerard I, Hah, Nasun, Littlewood, Trevor D, Sodir, Nicole M, Campos, Tania, Downes, Michael, Evans, Ronald M

“…The "hallmarks" of pancreatic ductal adenocarcinoma (PDAC) include proliferative, invasive, and metastatic tumor cells and an associated dense desmoplasia…”
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Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma by Amaravadi, Ravi K, Yu, Duonan, Lum, Julian J, Bui, Thi, Christophorou, Maria A, Evan, Gerard I, Thomas-Tikhonenko, Andrei, Thompson, Craig B

“…Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. Whether autophagy observed in…”
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Control of Politicians in Divided Societies: The Politics of Fear by PADRÓ I.MIQUEL, GERARD

“…Autocrats in many developing countries have extracted enormous personal rents from power. In addition, they have imposed inefficient policies including…”
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Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma by Massó-Vallés, Daniel, Jauset, Toni, Serrano, Erika, Sodir, Nicole M, Pedersen, Kim, Affara, Nesrine I, Whitfield, Jonathan R, Beaulieu, Marie-Eve, Evan, Gerard I, Elias, Laurence, Arribas, Joaquín, Soucek, Laura

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stromal fibroinflammatory reaction that is a major obstacle to effective therapy. The…”
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Selective Trials: A Principal-Agent Approach to Randomized Controlled Experiments by Chassang, Sylvain, Miquel, Gerard Padró i, Snowberg, Erik

“…We study the design of randomized controlled experiments when outcomes are significantly affected by experimental subjects' unobserved effort expenditure…”
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Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis by Annibali, Daniela, Whitfield, Jonathan R., Favuzzi, Emilia, Jauset, Toni, Serrano, Erika, Cuartas, Isabel, Redondo-Campos, Sara, Folch, Gerard, Gonzàlez-Juncà, Alba, Sodir, Nicole M., Massó-Vallés, Daniel, Beaulieu, Marie-Eve, Swigart, Lamorna B., Mc Gee, Margaret M., Somma, Maria Patrizia, Nasi, Sergio, Seoane, Joan, Evan, Gerard I., Soucek, Laura

“…Gliomas are the most common primary tumours affecting the adult central nervous system and respond poorly to standard therapy. Myc is causally implicated in…”
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Crime, Intimidation, and Whistleblowing: A Theory of Inference from Unverifiable Reports by CHASSANG, SYLVAIN, PADRÓ I MIQUEL, GERARD

“…We consider a game between a principal, an agent, and a monitor in which the principal would like to rely on messages by the monitor (the potential…”
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A Generalized Beta Prime Distribution as the Ratio Probability Density Function for Change Detection Between two SAR Intensity Images with Different Number of Looks by Peres, Gerard Gallardo i, Dall, Jorgen, Mason, Philippa J, Ghail, Richard, Hensley, Scott

“…In the framework of the comparison of Synthetic Aperture Radar (SAR) imagery from the Magellan space mission and the VISAR and VenSAR radar instruments which…”
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