Search Results - "Geraghty, Nicholas J."

Low Pretreatment CD4+:CD8+ T Cell Ratios and CD39+CD73+CD19+ B Cell Proportions Are Associated with Improved Relapse-Free Survival in Head and Neck Squamous Cell Carcinoma by Turner, Ross J., Guy, Thomas V., Geraghty, Nicholas J., Splitt, Ashleigh, Watson, Debbie, Brungs, Daniel, Carolan, Martin G., Miller, Andrew A., de Leon, Jeremiah F., Aghmesheh, Morteza, Sluyter, Ronald

“…The ectonucleotidases CD39 and CD73 are present on immune cells and play important roles in cancer progression by suppressing antitumour immunity. As such,…”
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Purinergic Signalling in Allogeneic Haematopoietic Stem Cell Transplantation and Graft-versus-Host Disease by Cuthbertson, Peter, Geraghty, Nicholas J., Adhikary, Sam R., Bird, Katrina M., Fuller, Stephen J., Watson, Debbie, Sluyter, Ronald

“…Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for blood cancers and other haematological disorders. However, allo-HSCT…”
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The Emerging Roles of Extracellular Chaperones in Complement Regulation by Geraghty, Nicholas J, Satapathy, Sandeep, Wilson, Mark R

“…The immune system is essential to protect organisms from internal and external threats. The rapidly acting, non-specific innate immune system includes…”
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Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells by Pupovac, Aleta, Geraghty, Nicholas J, Watson, Debbie, Sluyter, Ronald

“…Activation of the P2X7 receptor by the extracellular damage‐associated molecular pattern, adenosine 5′‐triphosphate (ATP), induces the shedding of cell surface…”
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Telomere length varies substantially between blood cell types in a reptile by Olsson, Mats, Geraghty, Nicholas J., Wapstra, Erik, Wilson, Mark

“…Telomeres are repeat sequences of non-coding DNA-protein molecules that cap or intersperse metazoan chromosomes. Interest in telomeres has increased…”
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Streptococcus pyogenes M1T1 Variants Induce an Inflammatory Neutrophil Phenotype Including Activation of Inflammatory Caspases by Williams, Jonathan G, Ly, Diane, Geraghty, Nicholas J, McArthur, Jason D, Vyas, Heema K N, Gorman, Jody, Tsatsaronis, James A, Sluyter, Ronald, Sanderson-Smith, Martina L

“…Invasive infections due to group A (GAS) advance rapidly causing tissue degradation and unregulated inflammation. Neutrophils are the primary immune cells that…”
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Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft‐versus‐host disease by Geraghty, Nicholas J, Watson, Debbie, Sluyter, Ronald

“…Allogeneic hematopoietic stem cell transplantation is a curative therapy for a number of hematological malignancies, but is limited by the development of…”
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Expanding the family of extracellular chaperones: Identification of human plasma proteins with chaperone activity by Geraghty, Nicholas J., Satapathy, Sandeep, Kelly, Megan, Cheng, Flora, Lee, Albert, Wilson, Mark R.

“…Proteostasis, the balance of protein synthesis, folding and degradation, is essential to maintain cellular function and viability, and the many known…”
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P2X7 receptor antagonism increases regulatory T cells and reduces clinical and histological graft-versus-host disease in a humanised mouse model by Cuthbertson, Peter, Geraghty, Nicholas J, Adhikary, Sam R, Casolin, Sienna, Watson, Debbie, Sluyter, Ronald

“…Graft-versus-host disease (GVHD) is a severe inflammatory response arising from allogeneic haematopoietic stem cell transplantation. Previous studies revealed…”
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Increased splenic human CD4+:CD8+ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice by Geraghty, Nicholas J., Belfiore, Lisa, Adhikary, Sam R., Alexander, Stephen I., Sluyter, Ronald, Watson, Debbie

“…Graft-versus-host disease (GVHD) is a frequent complication following allogeneic hematopoietic stem cell transplantation (HSCT) with current therapies limited…”
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Comparison of peripheral blood mononuclear cell isolation techniques and the impact of cryopreservation on human lymphocytes expressing CD39 and CD73 by Turner, Ross J., Geraghty, Nicholas J., Williams, Jonathan G., Ly, Diane, Brungs, Daniel, Carolan, Martin G., Guy, Thomas V., Watson, Debbie, de Leon, Jeremiah F., Sluyter, Ronald

“…CD39 and CD73 are ecto-nucleotidases present on human peripheral blood mononuclear cells (PBMCs) and are emerging biomarkers on these cells in various…”
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The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice by Geraghty, Nicholas J., Mansfield, Kylie J., Fuller, Stephen J., Watson, Debbie, Sluyter, Ronald

“…Psoriasis is a chronic inflammatory skin disorder, characterised by epidermal hyperplasia (acanthosis) and leukocyte infiltration of the skin. Current…”
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Neuroserpin and transthyretin are extracellular chaperones that preferentially inhibit amyloid formation by West, Jennifer, Satapathy, Sandeep, Whiten, Daniel R, Kelly, Megan, Geraghty, Nicholas J, Proctor, Emma-Jayne, Sormanni, Pietro, Vendruscolo, Michele, Buxbaum, Joel N, Ranson, Marie, Wilson, Mark R

“…Neuroserpin is a secreted protease inhibitor known to inhibit amyloid formation by the Alzheimer’s beta peptide (Aβ). To test whether this effect was…”
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The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice by Ly, Diane, Dongol, Anjila, Cuthbertson, Peter, Guy, Thomas V., Geraghty, Nicholas J., Sophocleous, Reece A., Sin, Lucia, Turner, Bradley J., Watson, Debbie, Yerbury, Justin J., Sluyter, Ronald

“…The ATP-gated P2X7 ion channel has emerging roles in amyotrophic lateral sclerosis (ALS) progression. Pharmacological blockade of P2X7 with Brilliant Blue G…”
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Pharmacological blockade of the CD 39/ CD 73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft‐ versus ‐host disease by Geraghty, Nicholas J, Watson, Debbie, Sluyter, Ronald

“…Allogeneic hematopoietic stem cell transplantation is a curative therapy for a number of hematological malignancies, but is limited by the development of…”
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The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1 G93A mice by Ly, Diane, Dongol, Anjila, Cuthbertson, Peter, Guy, Thomas V, Geraghty, Nicholas J, Sophocleous, Reece A, Sin, Lucia, Turner, Bradley J, Watson, Debbie, Yerbury, Justin J, Sluyter, Ronald

“…The ATP-gated P2X7 ion channel has emerging roles in amyotrophic lateral sclerosis (ALS) progression. Pharmacological blockade of P2X7 with Brilliant Blue G…”
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