Search Results - "Geraedts, JPM"

Conception to ongoing pregnancy: the 'black box' of early pregnancy loss by Macklon, N S, Geraedts, J P M, Fauser, B C J M

“…Even when conditions are optimal, the maximum chance of a clinically recognized pregnancy occurring in a given menstrual cycle is 30-40%. Increasing evidence…”
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Intrauterine insemination by Aboulghar, M, Baird, DT, Collins, J, Evers, JLH, Fauser, BCJM, Lambalk, CB, Somigliana, E, Sunde, A, Tarlatzis, B, Crosignani, PG, Devroey, P, Diczfalusy, E, Diedrich, K, Fraser, L, Geraedts, JPM, Gianaroli, L, Glasier, A, Van Steirteghem, A

“…BACKGROUND Intrauterine insemination (IUI) with or without ovarian stimulation is a common treatment for infertility. Despite its popularity, the effectiveness…”
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Decision-making on preimplantation genetic diagnosis and prenatal diagnosis: a challenge for couples with hereditary breast and ovarian cancer by Derks-Smeets, I.A.P., Gietel-Habets, J.J.G., Tibben, A., Tjan-Heijnen, V.C.G., Meijer-Hoogeveen, M., Geraedts, J.P.M., van Golde, R., Gomez-Garcia, E., van den Bogaart, E., van Hooijdonk, M., de Die-Smulders, C.E.M., van Osch, L.A.D.M.

“…STUDY QUESTION How do couples with a BRCA1/2 mutation decide on preimplantation genetic diagnosis (PGD) and prenatal diagnosis (PND) for hereditary breast and…”
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PGD and heteroplasmic mitochondrial DNA point mutations: a systematic review estimating the chance of healthy offspring by Hellebrekers, D M E I, Wolfe, R, Hendrickx, A T M, de Coo, I F M, de Die, C E, Geraedts, J P M, Chinnery, P F, Smeets, H J M

“…Mitochondrial disorders are often fatal multisystem disorders, partially caused by heteroplasmic mitochondrial DNA (mtDNA) point mutations. Prenatal diagnosis…”
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Preimplantation genetic diagnosis by Geraedts, JPM, De Wert, GMWR

“…Pre‐implantation genetic diagnosis (PGD) is generally defined as the testing of pre‐implantation stage embryos or oocytes for genetic defects. It has been…”
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In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial by van Montfoort, Aafke P.A., Fiddelers, Audrey A.A., Janssen, J.Marij, Derhaag, Josien G., Dirksen, Carmen D., Dunselman, Gerard A.J., Land, Jolande A., Geraedts, Joep P.M., Evers, Johannes L.H., Dumoulin, John C.M.

“…BACKGROUND: Elective single embryo transfer (eSET) in a selected group of patients (i.e. young patients with at least one good quality embryo) reduces the…”
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Genetic aspects of female reproduction by Collins, J, Diedrich, K, Franks, S, Geraedts, JPM, Jacobs, PA, Karges, B, Kennedy, S, Marozzi, A, Regan, L, Baird, DT, Crosignani, PG, Devroey, P, Diczfalusy, E, Evers, JLH, Fauser, BCJM, Fraser, L, Gianaroli, L, Glasier, A, Liebaers, I, Ragni, G, Sunde, A, Tarlatzis, B, Van Steirteghem, A

“…BACKGROUND Sexual reproduction provides the means for preserving genetic identity and in turn, genetic variability may affect the ability to reproduce. This…”
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The uptake and outcome of prenatal and pre-implantation genetic diagnosis for Huntington's disease in the Netherlands (1998-2008) by van Rij, MC, de Koning Gans, PAM, van Belzen, MJ, Roos, RAC, Geraedts, JPM, De Rademaeker, M, Bijlsma, EK, de Die-Smulders, CEM

“…We aimed to study reproductive behaviour of couples opting for prenatal diagnosis (PND) and pre‐implantation genetic diagnosis (PGD) for Huntington's disease…”
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Anaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryos by Coonen, Edith, Derhaag, Josien G., Dumoulin, John C.M., van Wissen, Lucie C.P., Bras, Marijke, Janssen, Marij, Evers, Johannes L.H., Geraedts, Joep P.M.

“…BACKGROUND: Cleavage stage embryos as well as postimplantation embryos have been studied extensively over the years. However, our knowledge with respect to the…”
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Decreased human semen quality and organochlorine compounds in blood by Dallinga, Jan W., Moonen, Edwin J.C., Dumoulin, John C.M., Evers, Johannes L.H., Geraedts, Joep P.M., Kleinjans, Jos C.S.

“…BACKGROUND: Various studies have been performed in which potential effects of xenoestrogens on fertility or sperm parameters were investigated by comparing…”
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Prenatal testing for Huntington's disease in the Netherlands from 1998 to 2008 by van Rij, MC, de Koning Gans, PAM, Aalfs, CM, Elting, M, Ippel, PF, Maat-Kievit, JA, Vermeer, S, Verschuuren-Bemelmans, CC, van Belzen, MJ, Belfroid, RDM, Losekoot, M, Geraedts, JPM, Roos, RAC, Tibben, A, de Die-Smulders, CEM, Bijlsma, EK

“…This study aims to give an overview of the number of prenatal tests for Huntington's disease (HD), test results, and pregnancy outcomes in the Netherlands…”
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The transmission of OXPHOS disease and methods to prevent this by Jacobs, L.J.A.M., de Wert, G., Geraedts, J.P.M., de Coo, I.F.M., Smeets, H.J.M.

“…Diseases owing to defects of oxidative phosphorylation (OXPHOS) affect approximately 1 in 8000 individuals. Clinical manifestations can be extremely variable…”
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Growth rate of human preimplantation embryos is sex dependent after ICSI but not after IVF by Dumoulin, John C.M., Derhaag, Josien G., Bras, Marijke, Van Montfoort, Aafke P.A., Kester, Arnold D.M., Evers, Johannes L.H., Geraedts, Joep P.M., Coonen, Edith

“…BACKGROUND: There is concern that IVF and/or ICSI might have an adverse effect on embryonic development via epigenetic alterations. Such alterations might also…”
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Embryo development and chromosomal anomalies after ICSI: effect of the injection procedure by Dumoulin, John C.M., Coonen, Edith, Bras, Marijke, Bergers-Janssen, J.Marij, Ignoul-Vanvuchelen, Rosie C.M., van Wissen, Lucie C.P., Geraedts, Joep P.M., Evers, Johannes L.H.

“…Intracytoplasmic sperm injection (ICSI) is a delicate procedure requiring considerable skills of the person performing it. Theoretically, the injection…”
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Comparison of in-vitro development of embryos originating from either conventional in-vitro fertilization or intracytoplasmic sperm injection by Dumoulin, John C.M., Coonen, Edith, Bras, Marijke, van Wissen, Lucie C.P., Ignoul-Vanvuchelen, Rosie, Bergers-Jansen, J.Marij, Derhaag, Josien G., Geraedts, Joep P.M., Evers, Johannes L.H.

“…In this retrospective study on 1628 consecutive cycles performed during a period of 4 years, development in vitro is compared of embryos obtained after either…”
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Effect of oxygen concentration on human in-vitro fertilization and embryo culture by Dumoulin, John C.M., Meijers, Chantal J.J., Bras, Marijke, Coonen, Edith, Geraedts, Joep P.M., Evers, Johannes L.H.

“…In this prospective randomized study on 1380 consecutive in-vitro fertilization (IVF) treatments, the results were compared of culture of human oocytes and…”
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Comparison of gonosomal aneuploidy in spermatozoa of normal fertile men and those with severe male factor detected by in-situ hybridization by BERNARDINI, L, MARTINI, E, GERAEDTS, J. P. M, HOPMAN, A. H. N, LANTERI, S, CONTE, N, CAPITANIO, G. L

“…The purpose of the study was to analyse the frequency of sex-chromosome numerical abnormalities in human spermatozoa of infertile men by using a standardized…”
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Chromosomally abnormal cells are not selected for the extra‐embryonic compartment of the human preimplantation embryo at the blastocyst stage by Derhaag, Josien G., Coonen, Edith, Bras, Marijke, Bergers Janssen, J.Marij, Ignoul‐Vanvuchelen, Rosie, Geraedts, Joep P.M., Evers, Johannes L.H., Dumoulin, John C.M.

“…BACKGROUND: Although well defined for embryos at cleavage stages, the occurrence and frequency of chromosomal aberrations in human blastocysts is relatively…”
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Multiplex PCR of polymorphic markers flanking the CFTR gene; a general approach for preimplantation genetic diagnosis of cystic fibrosis by Dreesen, J.C.F.M., Jacobs, L.J.A.M., Bras, M., Herbergs, J., Dumoulin, J.C.M., Geraedts, J.P.M., Evers, J.L.H., Smeets, H.J.M.

“…Cystic fibrosis (CF) is the first monogenic disorder for which single cell preimplantation genetic diagnosis (PGD) has been successfully applied. The spectrum…”
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Transmission and prenatal diagnosis of the T9176C mitochondrial DNA mutation by Jacobs, L.J.A.M., de Coo, I.F.M., Nijland, J.G., Galjaard, R.J.H., Los, F.J., Schoonderwoerd, K., Niermeijer, M.F., Geraedts, J.P.M., Scholte, H.R., Smeets, H.J.M.

“…A family presented with three affected children with Leigh syndrome, a progressive neurodegenerative disorder. Analysis of the OXPHOS complexes in muscle of…”
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