Search Results - "Gera, Ruchi"

Zinc Oxide Nanoparticle Induces Microglial Death by NADPH-Oxidase-Independent Reactive Oxygen Species as well as Energy Depletion by Sharma, Anuj Kumar, Singh, Vikas, Gera, Ruchi, Purohit, Mahaveer Prasad, Ghosh, Debabrata

“…Zinc oxide nanoparticle (ZnO-NP) is one of the most widely used engineered nanoparticles. Upon exposure, nanoparticle can eventually reach the brain through…”
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Tributyltin induces oxidative damage, inflammation and apoptosis via disturbance in blood–brain barrier and metal homeostasis in cerebral cortex of rat brain: An in vivo and in vitro study by Mitra, Sumonto, Gera, Ruchi, Siddiqui, Waseem A, Khandelwal, Shashi

“…Highlights • Sustainable blood–brain barrier disruption was found by single acute dose of TBTC (up to 1 week). • Imbalance in essential metal homeostasis in…”
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Positive and negative selection shape the human naive B cell repertoire by Chen, Jeff W, Schickel, Jean-Nicolas, Tsakiris, Nikolaos, Sng, Joel, Arbogast, Florent, Bouis, Delphine, Parisi, Daniele, Gera, Ruchi, Boeckers, Joshua M, Delmotte, Fabien R, Veselits, Margaret, Schuetz, Catharina, Jacobsen, Eva-Maria, Posovszky, Carsten, Schulz, Ansgar S, Schwarz, Klaus, Clark, Marcus R, Menard, Laurence, Meffre, Eric

“…Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection…”
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Arsenic exposure impels CD4 commitment in thymus and suppress T cell cytokine secretion by increasing regulatory T cells by Gera, Ruchi, Singh, Vikas, Mitra, Sumonto, Sharma, Anuj Kumar, Singh, Alok, Dasgupta, Arunava, Singh, Dhirendra, Kumar, Mahadeo, Jagdale, Pankaj, Patnaik, Satyakam, Ghosh, Debabrata

“…Arsenic is globally infamous for inducing immunosuppression associated with prevalence of opportunistic infection in exposed population, although the mechanism…”
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Isolation and Characterization of Microglia from Adult Mouse Brain: Selected Applications for ex Vivo Evaluation of Immunotoxicological Alterations Following in Vivo Xenobiotic Exposure by Singh, Vikas, Mitra, Sumonto, Sharma, Anuj Kumar, Gera, Ruchi, Ghosh, Debabrata

“…Microglia play a dual role in neuroprotection as well as in neurodegeneration and thus occupy the focal interest in neurodegenerative disease research. In…”
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Microglia Impairs Proliferation and Induces Senescence In-Vitro in NGF Releasing Cells Used in Encapsulated Cell Biodelivery for Alzheimer’s Disease Therapy by Mitra, Sumonto, Gera, Ruchi, Sundheimer, Julia, Lemee, Marine, Wahlberg, Lars U., Linderoth, Bengt, Eriksdotter, Maria, Behbahani, Homira

“…There is no cure yet available for Alzheimer’s disease (AD). We recently optimized encapsulated cell biodelivery (ECB) devices releasing human mature nerve…”
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Fluorometric Estimation of Glutathione in Cultured Microglial Cell Lysate by Singh, Vikas, Gera, Ruchi, Prasad Purohit, Mahaveer, Patnaik, Satyakam, Ghosh, Debabrata

“…Glutathione is one of the major antioxidant defense components present in cells. It is predominantly present as reduced glutathione (GSH) and converted into…”
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Actinic cheilitis: A review by Somasundaram, Elangovan, Gera, Ruchi, Peethambaran, Harish

“…Actinic cheilitis (AC) is a chronic inflammatory disorder of the lips that is caused by prolonged exposure to sunlight in susceptible individuals. It affects…”
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Characteristics of peripheral immune system in a novel App NL‐G‐F knock‐in mouse model of Alzheimer’s disease by Gera, Ruchi, Mitra, Sumonto, Tambaro, Simone, Nilsson, Per, Eriksdotter, Maria

“…Abstract Background Increasing epidemiological, clinical, and experimental evidence suggests that Alzheimer’s disease (AD) pathogenesis is closely associated…”
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Characteristics of peripheral immune system in a novel AppNL‐G‐F knock‐in mouse model of Alzheimer’s disease by Gera, Ruchi, Mitra, Sumonto, Tambaro, Simone, Nilsson, Per, Eriksdotter, Maria

“…Background Increasing epidemiological, clinical, and experimental evidence suggests that Alzheimer’s disease (AD) pathogenesis is closely associated with…”
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The microglial challenge to encapsulated cell mediated drug delivery in brain tissue by Mitra, Sumonto, Gera, Ruchi, Sundheimer, Julia, Lemee, Marine, Wahlberg, Lars, Linderoth, Bengt, Behbahani, Homira, Eriksdotter, Maria

“…Background Dementia disorders affect millions of people worldwide, among which Alzheimer’s disease (AD) accounts for 60% cases. Treatment of these disorders…”
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Cholinergic pathway modulation by age‐dependent amyloid‐beta pathology in an APP‐knock‐in AD mice model by Mitra, Sumonto, Gera, Ruchi, Tambaro, Simone, Nilsson, Per, Linderoth, Bengt, Behbahani, Homira, Darreh‐Shori, Taher, Eriksdotter, Maria

“…Background Altered cholinergic pathways and memory dysfunction are well‐known changes during Alzheimer’s disease (AD), linked to the early loss of basal…”
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Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia by Vineeth Daniel, P., Kamthan, Mohan, Gera, Ruchi, Dogra, Surbhi, Gautam, Krishna, Ghosh, Debabrata, Mondal, Prosenjit

“…Dysregulated hepatic de novo lipogenesis contributes to the pathogenesis of nonalcoholic fatty liver disease in both humans and rodents. Clinical evidence…”
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Hippocampal BDNF encapsulated cell bio‐delivery improves spontaneous behavioral alternations in the Y‐maze test in AppNL‐G‐F mice by Tambaro, Simone, Mitra, Sumonto, Gera, Ruchi, Linderoth, Bengt, Wahlberg, Lars, Behbahani, Homira, Darreh‐Shori, Taher, Nilsson, Per, Eriksdotter, Maria

“…Background Alzheimer’s disease (AD) is an age‐related disease characterized by synaptic dysfunction, brain inflammation, and neurodegeneration against which…”
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Hippocampal BDNF encapsulated cell bio‐delivery improves spontaneous behavioral alternations in the Y‐maze test in App NL‐G‐F mice by Tambaro, Simone, Mitra, Sumonto, Gera, Ruchi, Linderoth, Bengt, Wahlberg, Lars, Behbahani, Homira, Darreh‐Shori, Taher, Nilsson, Per, Eriksdotter, Maria

“…Abstract Background Alzheimer’s disease (AD) is an age‐related disease characterized by synaptic dysfunction, brain inflammation, and neurodegeneration against…”
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Sneaky Entry of IFNγ Through Arsenic-Induced Leaky Blood–Brain Barrier Reduces CD200 Expression by Microglial pro-Inflammatory Cytokine by Singh, Vikas, Kushwaha, Shaivya, Gera, Ruchi, Ansari, Jamal Ahmad, Mishra, Juhi, Dewangan, Jayant, Patnaik, Satyakam, Ghosh, Debabrata

“…Recent studies showed that neuronal surface protein CD200 plays a key role in the regulation of neuroinflammation. Previously, we showed that arsenic…”
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Comparative toxicity of low dose tributyltin chloride on serum, liver, lung and kidney following subchronic exposure by Mitra, Sumonto, Gera, Ruchi, Singh, Vikas, Khandelwal, Shashi

“…•Subchronic exposure to low dose tributyltin results in multi-organ toxicity.•Alterations in liver morphology but not serum parameters were observed.•δ-ALAD…”
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Chronic exposure to Pb 2+ perturbs Ch REBP transactivation and coerces hepatic dyslipidemia by Vineeth Daniel, P., Kamthan, Mohan, Gera, Ruchi, Dogra, Surbhi, Gautam, Krishna, Ghosh, Debabrata, Mondal, Prosenjit

“…Dysregulated hepatic de novo lipogenesis contributes to the pathogenesis of nonalcoholic fatty liver disease in both humans and rodents. Clinical evidence…”
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Hijacking microglial glutathione by inorganic arsenic impels bystander death of immature neurons through extracellular cystine/glutamate imbalance by Singh, Vikas, Gera, Ruchi, Kushwaha, Rajesh, Sharma, Anuj Kumar, Patnaik, Satyakam, Ghosh, Debabrata

“…Arsenic-induced altered microglial activity leads to neuronal death, but the causative mechanism remains unclear. The present study showed, arsenic-exposed (10…”
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Presence of key cholinergic enzymes in human spermatozoa and seminal fluid by Thakur, Banita, Hasooni, Laila Pamela, Gera, Ruchi, Mitra, Sumonto, Björndahl, Lars, Darreh-Shori, Taher

“…Little is known about the non-neuronal spermic cholinergic system, which may regulate sperm motility and the acrosome reaction initiation process. We…”
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