Search Results - "Geppert, TD"

Association of various T cell-surface molecules with the cytoskeleton. Effect of cross-linking and activation by Geppert, TD, Lipsky, PE

“…The association of various surface molecules with the cytoskeleton in resting peripheral blood T cells was examined by assaying the capacity of detergent to…”
Get full text

Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK by Swantek, Jennifer L., Cobb, Melanie H., Geppert, Thomas D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

MEK1 and the extracellular signal-regulated kinases are required for the stimulation of IL-2 gene transcription in T cells by Whitehurst, CE, Geppert, TD

“…TCR engagement stimulates the activation of the protein kinase Raf-1. Active Raf-1 phosphorylates and activates the mitogen-activated protein (MAP)…”
Get full text

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro by ROBBINS, D. J, ZHEN, E, OWAKI, H, VANDERBILT, C. A, EBERT, D, GEPPERT, T. D, COBB, M. H

“…Extracellular signal-regulated protein kinases (ERK) 1 and 2 and mutants of each were expressed in bacteria with a hexahistidine tag and purified using…”
Get full text

A Requirement for Extracellular Signal-Regulated Kinase (ERK) Function in the Activation of AP-1 by Ha-Ras, Phorbol 12-Myristate 13-Acetate, and Serum by Frost, Jeffrey A., Geppert, Thomas D., Cobb, Melanie H., Feramisco, James R.

“…The role of ERK-1 and ERK-2 in wild-type (wt) Ha-Ras, phorbol 12-myristate 13-acetate (PMA), and serum-induced AP-1 activity was studied. Microinjection of…”
Get full text

Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the ras/raf-1/MEK/MAPK pathway by Geppert, T D, Whitehurst, C E, Thompson, P, Beutler, B

“…Lipopolysaccharide (LPS) is known to activate macrophages, causing the release of toxic cytokines that may provoke inflammation and shock. One of the most…”
Get full text

Accessory cell signals involved in T-cell activation by Geppert, T D, Davis, L S, Gur, H, Wacholtz, M C, Lipsky, P E

Get more information

Antigen presentation by interferon-gamma-treated endothelial cells and fibroblasts: differential ability to function as antigen-presenting cells despite comparable Ia expression by Geppert, TD, Lipsky, PE

“…The effect of interferon-gamma (IFN-gamma) on endothelial cell (EC) and fibroblast (FB) class II major histocompatibility complex (MHC) gene product expression…”
Get full text

Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha by Yokota, S, Geppert, TD, Lipsky, PE

“…The capacity of human recombinant tumor necrosis factor-alpha (rTNF alpha) to modulate human T cell proliferation was examined. To examine the effect of rTNF…”
Get full text

Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta- phorbol 12-myristate 13-acetate-induced phosphorylation and activation by Whitehurst, CE, Boulton, TG, Cobb, MH, Geppert, TD

“…Extracellular signal-regulated kinases (ERK) 1 and 2 are growth factor- and cytokine-sensitive serine/threonine kinases that are known to phosphorylate…”
Get full text

Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3 by Geppert, TD, Lipsky, PE

“…The capacity of the monoclonal antibodies (Mab) 64.1 and OKT3 directed at CD3 molecules to induce T4 cell proliferation and interleukin 2 (IL 2) production was…”
Get full text

Raf‐1 is required for T cell IL2 production by Owaki, H., Varma, R., Gillis, B., Bruder, J.T., Rapp, U.R., Davis, L.S., Geppert, T.D.

“…Engagement of the T cell receptor/CD3 complex activates the serine/threonine kinase, Raf‐1, but the physiologic consequences of its activation have not been…”
Get full text

The MEK Kinase Activity of the Catalytic Domain of RAF-1 Is Regulated Independently of Ras Binding in T Cells (∗) by Whitehurst, Charles E., Owaki, Hajime, Bruder, Joseph T., Rapp, Ulf R., Geppert, Thomas D.

“…Deletion of the amino-terminal domain of Raf-1, which contains the Ras-binding region, results in the constitutive activation of the liberated Raf-1 catalytic…”
Get full text

The Cytoplasmic and the Transmembrane Domains Are Not Sufficient for Class I MHC Signal Transduction by Gur, Hanan, Geppert, Thomas D., Wacholtz, Mary C., Lipsky, Peter E.

“…Class I MHC molecules deliver activation signals to T cells. To analyze the role of the cytoplasmic and the transmembrane (TM) domains of class I MHC molecules…”
Get full text

Structural analysis of class I MHC molecules: The cytoplasmic domain is not required for cytoskeletal association, aggregation and internalization by Gur, Hanan, Geppert, Thomas D., Lipsky, Peter E.

“…The role of the cytoplasmic domain in a variety of the functional activities of class 1 MHC molecules has not been documented. To address this question, Jurkat…”
Get full text

Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs by Owaki, H, Makar, R, Boulton, T G, Cobb, M H, Geppert, T D

“…Extracellular signal-regulated kinases 1 and 2 are growth factor-sensitive serine/threonine kinases. cDNAs for both human kinases were isolated and sequenced…”
Get more information

Dissection of defective antigen presentation by interferon-gamma- treated fibroblasts by Geppert, TD, Lipsky, PE

“…The capacity of interferon-gamma (IFN-gamma)-treated HLA-DR expressing human dermal fibroblasts (FB) to function as antigen-presenting cells (APC) was…”
Get full text

Activation of human T4 cells by cross-linking class I MHC molecules by Geppert, TD, Wacholtz, MC, Davis, LS, Lipsky, PE

“…These studies examined whether cross-linking class I MHC molecules results in functional or biochemical responses in human T4 cells. The initial studies…”
Get full text

Activation of human T cell clones and Jurkat cells by cross-linking class I MHC molecules by Geppert, TD, Wacholtz, MC, Patel, SS, Lightfoot, E, Lipsky, PE

“…Cross-linking class I MHC molecules on human T cell clones by reacting them with various mAb directed at either monomorphic or polymorphic determinants on…”
Get full text

Engagement of class I major histocompatibility complex molecules by cell surface CD8 delivers an activation signal by Geppert, T D, Nguyen, H, Lipsky, P E

“…Recent evidence has demonstrated that cross-linking class I major histocompatibility complex (MHC) molecules on human T cells with monoclonal antibodies (mAb)…”
Get more information