Search Results - "Georgieva, S G"

PHF10 subunit of PBAF complex mediates transcriptional activation by MYC by Soshnikova, N. V., Tatarskiy, E. V., Tatarskiy, V. V., Klimenko, N. S., Shtil, A. A., Nikiforov, M. A., Georgieva, S. G.

“…The PBAF complex, a member of SWI/SNF family of chromatin remodelers, plays an essential role in transcriptional regulation. We revealed a disease progression…”
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Xmas-2 Protein, the Core Protein of the TREX-2 mRNA Export Complex, Does not Determine the Specificity of ras2 mRNA Binding by the Complex by Kurshakova, M. M., Vdovina, Y. A., Georgieva, S. G., Kopytova, D. V.

“…The TREX-2 complex of eukaryotes is responsible for the export of a wide range of mRNAs from the nucleus to the cytoplasm. Previously, we showed that a subunit…”
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Point Mutations in the M Domain of PCID2 Impair Its Function in mRNA Export in Drosophila melanogaster by Vdovina, Yu. A., Georgieva, S. G., Kopytova, D. V.

“…The PCID2 protein is a component of the eukaryotic TREX-2 complex, which is responsible for mRNA export from the nucleus into the cytoplasm. We have previously…”
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Interaction of mRNA with the C-Terminal Domain of PCID2, a Subunit of the TREX-2 Complex, Is Required for Its Export from the Nucleus to the Cytoplasm in Drosophila melanogaster by Vdovina, Yu. A., Georgieva, S. G., Kopytova, D. V.

“…Following the transcription step, the newly synthesized mRNA is exported from the nucleus to the cytoplasm and further to the translation site. The TREX-2…”
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TREX-2-ORC Complex of D. melanogaster Participates in Nuclear Export of Histone mRNA by Kurshakova, M. M., Yakusheva, Y. A., Georgieva, S. G.

“…The TREX-2-ORC protein complex of D. melanogaster is necessary for the export of the bulk of synthesized poly(A)-containing mRNA molecules from the nucleus to…”
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Chromatin Remodeling Complex PBAF Activates and Represses Inflammatory Genes by Feoktistov, A. V., Georgieva, S. G., Soshnikova, N. V.

“…The PBAF chromatin remodeling complex regulates chromatin state and gene transcription in higher eukaryotes. In this work, we studied the role of PBAF in the…”
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The Human TREX-2 Complex Interacts with Subunits of the ORC Complex by Kurshakova, M. M., Georgieva, S. G., Kopytova, D. V.

“…The TREX-2 protein complex is the key complex involved in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a joint…”
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The Xmas-2 Protein of Drosophila melanogaster Undergoes Cleavage into Two Fragments by Kurshakova, M. M., Georgieva, S. G., Kopytova, D. V.

“…The TREX-2 complex integrates several stages of gene expression, such as transcriptional activation and mRNA export. In D. melanogaster , TREX-2 consists of…”
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Neuronal and Muscle Differentiation of Mammalian Cells Is Accompanied by a Change in PHF10 Isoform Expression by Bayramova, D. O., Azieva, A. M., Feoktistov, A. V., Georgieva, S. G., Soshnikova, N. V.

“…The PBAF chromatin remodeling complex of the SWI/SNF family plays a critical role in the regulation of gene expression during tissue differentiation and…”
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Contact Inhibition of Proliferation Is Accompanied by Expression of the PHF10D Subunit of the Chromatin Remodeling Complex PBAF in Mouse and Human Cell Lines by Simonov, Yu. P., Tatarskiy, V. V., Georgieva, S. G., Soshnikova, N. V.

“…PHF10 is a subunit of the PBAF complex, which regulates the expression of many genes in developing and maturing organisms. PHF10 has four isoforms that differ…”
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Study of the Interaction between Xmas-2, the Main Protein of TREX-2 mRNA Export Complex, and the Orc3 Protein, a Subunit of ORC Complex of D. melanogaster by Kurshakova, M. M., Kopytova, D. V., Georgieva, S. G.

“…The TREX-2 protein complex is the key participant in the export of mRNA from the nucleus to the cytoplasm through the nuclear pores. Previously, a protein…”
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MLE Helicase Is a New Participant in the Transcription Regulation of the ftz-f1 Gene Encoding Nuclear Receptor in Higher Eukaryotes by Nikolenko, J. V., Kurshakova, M. M., Krasnov, A. N., Georgieva, S. G.

“…MLE helicase is an evolutionarily conserved eukaryotic protein involved in a wide range of processes in the regulation of gene expression. Previously, we…”
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The Emergence of a New Isoform of POU2F1 in Primates through the Use of Egoistic Mobile Genetic Elements by Lyanova, B. M., Kotnova, A. P., Makarova, A. A., Ilyin, Yu. V., Georgieva, S. G., Stepchenko, A. G., Pankratova, E. V.

“…The emergence of new genes and functions is of paramount importance in the emergence of new animal species. For example, the insertion of the mobile element…”
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5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt’s Lymphoma Cell Culture by Kotnova, A. P., Stepchenko, A. G., Ilyin, Yu. V., Georgieva, S. G., Pankratova, E. V.

“…Overexpression of the transcription factor POU2F1 (Oct-1) increases the malignant potential of the tumor and determines the unfavorable prognosis for both…”
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GSK3 Kinase Inhibitor, CHIR, Suppress Transcription of Tissue Specific POU2F1 Isoform in Burkitt Namalwa Lymphoma Cells by Pankratova, E. V., Portseva, T. N., Makarova, A. A., Ilyin, Yu. V., Stepchenko, A. G., Georgieva, S. G.

“…POU2F1 (Oct-1) is a transcription factor, the overexpression of which is found in many human malignant tumors; a significant increase in its level in cells…”
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Differentiation of IMR32 Neuroblastoma Is Accompanied by a Global Change in the Transcriptome by Stepchenko, A. G., Portseva, T. N., Ilyin, Yu. V., Georgieva, S. G., Pankratova, E. V.

“…Neuroblastoma is one of the most common cancers in infants and is often multidrug-resistant. One of the methods of treating neuroblastomas is to create…”
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Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins by Vdovina, Y. A., Georgieva, S. G., Kopytova, D. V.

“…The process of mRNA localization in the cytoplasm involves the directed transport of mRNP particles using the microtubule system. This transport is mediated…”
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Production of human lactoferrin in animal milk by Goldman, I L, Georgieva, S G, Gurskiy, Ya G, Krasnov, A N, Deykin, A V, Popov, A N, Ermolkevich, T G, Budzevich, A I, Chernousov, A D, Sadchikova, E R

“…Genetic constructs containing the human lactoferrin (hLf) gene were created within a joint program of Russian and Belorussian scientists. Using these…”
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Assembly and Disassembly of the Nuclear Pore Complex: A View from the Structural Side by Orlova, A. V., Georgieva, S. G., Kopytova, D. V.

“…—Nucleocytoplasmic exchange in the cell occurs through the nuclear pore complexes (NPCs). NPCs are large multiprotein complexes with octagonal symmetry about…”
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Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles by Kurshakova, M. M., Krasnov, A. N., Nabirochkina, E. N., Georgieva, S. G.

“…ENY2 is an evolutionarily conserved multifunctional protein and is a member of several complexes that regulate various stages of gene expression. ENY2 is a…”
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