Search Results - "Georgieva, R"

Protein Conformational Dynamics upon Association with the Surfaces of Lipid Membranes and Engineered Nanoparticles: Insights from Electron Paramagnetic Resonance Spectroscopy by Georgieva, Elka R

“…Detailed study of conformational rearrangements and dynamics of proteins is central to our understanding of their physiological functions and the loss of…”
Get full text

Engineered Chimera Protein Constructs to Facilitate the Production of Heterologous Transmembrane Proteins in E. coli by Ogunbowale, Adeyemi, Georgieva, Elka R

“…To delve into the structure-function relationship of transmembrane proteins (TMPs), robust protocols are needed to produce them in a pure, stable, and…”
Get full text

Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB by Cooper, Rebecca S., Georgieva, Elka R., Borbat, Peter P., Freed, Jack H., Heldwein, Ekaterina E.

“…Viral fusogens merge viral and cell membranes during cell penetration. Their ectodomains drive fusion by undergoing large-scale refolding, but little is known…”
Get full text

Lipid Membrane Mimetics in Functional and Structural Studies of Integral Membrane Proteins by Majeed, Saman, Ahmad, Akram Bani, Sehar, Ujala, Georgieva, Elka R.

“…Integral membrane proteins (IMPs) fulfill important physiological functions by providing cell–environment, cell–cell and virus–host communication; nutrients…”
Get full text

Conformational ensemble of the sodium-coupled aspartate transporter by Georgieva, Elka R, Borbat, Peter P, Ginter, Christopher, Freed, Jack H, Boudker, Olga

“…The sodium and aspartate symporter Glt Ph mediates transport by alternating between outward-facing and inward-facing states. These conformational changes are…”
Get full text

Transport domain unlocking sets the uptake rate of an aspartate transporter by Akyuz, Nurunisa, Georgieva, Elka R., Zhou, Zhou, Stolzenberg, Sebastian, Cuendet, Michel A., Khelashvili, George, Altman, Roger B., Terry, Daniel S., Freed, Jack H., Weinstein, Harel, Boudker, Olga, Blanchard, Scott C.

“…Glutamate transporters terminate neurotransmission by clearing synaptically released glutamate from the extracellular space, allowing repeated rounds of…”
Get full text

Tau Binds to Lipid Membrane Surfaces via Short Amphipathic Helices Located in Its Microtubule-Binding Repeats by Georgieva, Elka R., Xiao, Shifeng, Borbat, Peter P., Freed, Jack H., Eliezer, David

“…Tau is a microtubule-associated protein that is genetically linked to dementia and linked to Alzheimer’s disease via its presence in intraneuronal…”
Get full text

Non-Structural Proteins from Human T-cell Leukemia Virus Type 1 in Cellular Membranes-Mechanisms for Viral Survivability and Proliferation by Georgieva, Elka R

“…Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of illnesses, such as adult T-cell leukemia/lymphoma, myelopathy/tropical spastic…”
Get full text

Signature of an aggregation-prone conformation of tau by Eschmann, Neil A., Georgieva, Elka R., Ganguly, Pritam, Borbat, Peter P., Rappaport, Maxime D., Akdogan, Yasar, Freed, Jack H., Shea, Joan-Emma, Han, Songi

“…The self-assembly of the microtubule associated tau protein into fibrillar cell inclusions is linked to a number of devastating neurodegenerative disorders…”
Get full text

HIV-1 Vpu protein forms stable oligomers in aqueous solution via its transmembrane domain self-association by Majeed, Saman, Dang, Lan, Islam, Md Majharul, Ishola, Olamide, Borbat, Peter P., Ludtke, Steven J., Georgieva, Elka R.

“…We report our findings on the assembly of the HIV-1 protein Vpu into soluble oligomers. Vpu is a key HIV-1 protein. It has been considered exclusively a…”
Get full text

Mechanism of influenza A M2 transmembrane domain assembly in lipid membranes by Georgieva, Elka R., Borbat, Peter P., Norman, Haley D., Freed, Jack H.

“…M2 from influenza A virus functions as an oligomeric proton channel essential for the viral cycle, hence it is a high-priority pharmacological target whose…”
Get full text

Docosahexaenoic acid promotes micron scale liquid-ordered domains. A comparison study of docosahexaenoic versus oleic acid containing phosphatidylcholine in raft-like mixtures by Georgieva, R., Chachaty, C., Hazarosova, R., Tessier, C., Nuss, P., Momchilova, A., Staneva, G.

“…The understanding of the functional role of the lipid diversity in biological membranes is a major challenge. Lipid models have been developed to address this…”
Get full text

Advanced algorithms for multidimensional sensitivity studies of large-scale air pollution models based on Sobol sequences by Dimov, I., Georgieva, R., Ostromsky, Tz, Zlatev, Z.

“…In this paper advanced variance-based algorithms for global sensitivity analysis are studied. We consider efficient algorithms, such as Monte Carlo,…”
Get full text

Nanoscale lipid membrane mimetics in spin-labeling and electron paramagnetic resonance spectroscopy studies of protein structure and function by Georgieva Elka R.

“…Cellular membranes and associated proteins play critical physiological roles in organisms from all life kingdoms. In many cases, malfunction of biological…”
Get full text

Monte Carlo sensitivity analysis of an Eulerian large-scale air pollution model by Dimov, I., Georgieva, R., Ostromsky, Tz

“…Variance-based approaches for global sensitivity analysis have been applied and analyzed to study the sensitivity of air pollutant concentrations according to…”
Get full text

Photosensitizer-loaded electrospun chitosan-based scaffolds for photodynamic therapy and tissue engineering by Severyukhina, A.N., Petrova, N.V., Smuda, K., Terentyuk, G.S., Klebtsov, B.N., Georgieva, R., Bäumler, H., Gorin, D.A.

“…[Display omitted] •Electrospun materials containing a second generation photosensitizer were prepared.•Release kinetics of PS from the materials was described…”
Get full text

Magnetite-Loaded Carrier Erythrocytes as Contrast Agents for Magnetic Resonance Imaging by Brähler, M, Georgieva, R, Buske, N, Müller, A, Müller, S, Pinkernelle, J, Teichgräber, U, Voigt, A, Bäumler, H

“…Superparamagnetic iron oxide nanoparticles (SPIONs) are commonly used in magnetic resonance imaging (MRI), but their fast phagocytosis makes them less than…”
Get full text

A facile approach for the in vitro assembly of multimeric membrane transport proteins by Riederer, Erika A, Focke, Paul J, Georgieva, Elka R, Akyuz, Nurunisa, Matulef, Kimberly, Borbat, Peter P, Freed, Jack H, Blanchard, Scott C, Boudker, Olga, Valiyaveetil, Francis I

“…Membrane proteins such as ion channels and transporters are frequently homomeric. The homomeric nature raises important questions regarding coupling between…”
Get full text

Non-Destructive Mechanical Testing of Allograft Bone-Implants by Analytic Centrifugation by Bäumler, H., Hamberger, L., Zaslansky, P., Kalus, U., Georgieva, R., Pruss, A.

“…An analytical centrifugation technique (LUMiFuge) for mechanical testing is introduced. Measurements on calibrated springs with LUMiFuge and BOSE…”
Get full text

Studying the sensitivity of pollutants’ concentrations caused by variations of chemical rates by Dimov, I., Georgieva, R., Ivanovska, S., Ostromsky, Tz, Zlatev, Z.

“…A systematic procedure for sensitivity analysis of a case study in the area of air pollution modeling has been performed. Contemporary mathematical models…”
Get full text