Search Results - "Georges Rawadi"

The Keystone commensal bacterium Christensenella minuta DSM 22607 displays anti-inflammatory properties both in vitro and in vivo by Kropp, Camille, Le Corf, Katy, Relizani, Karima, Tambosco, Kevin, Martinez, Ccori, Chain, Florian, Rawadi, Georges, Langella, Philippe, Claus, Sandrine P., Martin, Rebeca

“…Christensenellaceae is a family of subdominant commensal bacteria found in humans. It is thought to play an important role in gut health by maintaining…”
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Selection of a novel strain of Christensenella minuta as a future biotherapy for Crohn’s disease by Relizani, Karima, Le Corf, Katy, Kropp, Camille, Martin-Rosique, Rebeca, Kissi, Déborah, Déjean, Guillaume, Bruno, Lisa, Martinez, Ccori, Rawadi, Georges, Elustondo, Frédéric, Mazier, Wilfrid, Claus, Sandrine P.

“…Microbiome-based therapies for inflammatory bowel diseases offer a novel and promising therapeutic approach. The human commensal bacteria of the species…”
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BMP‐2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop by Rawadi, Georges, Vayssière, Béatrice, Dunn, Fred, Baron, Roland, Roman‐Roman, Sergio

“…Wnt/β‐catenin signaling has recently been suggested to be involved in bone biology. The precise role of this cascade in osteoblast differentiation was…”
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A New Strain of Christensenella minuta as a Potential Biotherapy for Obesity and Associated Metabolic Diseases by Mazier, Wilfrid, Le Corf, Katy, Martinez, Ccori, Tudela, Héloïse, Kissi, Déborah, Kropp, Camille, Coubard, Chrislain, Soto, Marion, Elustondo, Frédéric, Rawadi, Georges, Claus, Sandrine P

“…Obesity is associated with gut microbiota dysbiosis, characterized by a high Firmicutes/Bacteroidetes ratio. Gut-dwelling bacteria of the Christensenellaceae…”
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Wnt signaling and potential applications in bone diseases by Rawadi, Georges

“…In the United States, it is estimated that $10-15 billion is spent annually for the treatment of osteoporotic fracture. The worldwide annual incidence of…”
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Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass by Morvan, Frederic, Boulukos, Kim, Clément‐Lacroix, Philippe, Roman, Sergio Roman, Suc‐Royer, Isabelle, Vayssière, Béatrice, Ammann, Patrick, Martin, Patrick, Pinho, Sonia, Pognonec, Philippe, Mollat, Patrick, Niehrs, Christof, Baron, Roland, Rawadi, Georges

“…Wnt/β‐catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast…”
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Lrp5-Independent Activation of Wnt Signaling by Lithium Chloride Increases Bone Formation and Bone Mass in Mice by Philippe Clément-Lacroix, Minrong Ai, Frederic Morvan, Sergio Roman-Roman, Béatrice Vayssière, Cecille Belleville, Kenneth Estrera, Warman, Matthew L., Baron, Roland, Georges Rawadi, Prockop, Darwin J.

“…One of the well characterized cell biologic actions of lithium is the inhibition of glycogen synthase kinase-3/3 and the consequent activation of canonical Wnt…”
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Wnt signaling and the regulation of bone mass by Baron, Roland, Rawadi, Georges

“…Human genetic studies have firmly established a link between bone mass in humans and gain-of-function or loss-of-function mutations in a Wnt coreceptor,…”
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Entering First-in-Human Clinical Study With a Single-Strain Live Biotherapeutic Product: Input and Feedback Gained From the EMA and the FDA by Paquet, Jeanne-Céleste, Claus, Sandrine P, Cordaillat-Simmons, Magali, Mazier, Wilfrid, Rawadi, Georges, Rinaldi, Laure, Elustondo, Frédéric, Rouanet, Alice

“…During the last decade, a plethora of novel therapies containing live microorganisms as active substance(s) has emerged with the aim to treat, prevent, or cure…”
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Identifying a Novel Bile Salt Hydrolase from the Keystone Gut Bacterium Christensenella minuta by Déjean, Guillaume, Tudela, Héloïse, Bruno, Lisa, Kissi, Déborah, Rawadi, Georges, Claus, Sandrine P.

“…Christensenella minuta are human gut dwelling bacteria that have been proposed as key members of the gut microbiome, regulating energy balance and adiposity of…”
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Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density by Ellwanger, Kristina, Saito, Hiroaki, Clément-Lacroix, Philippe, Maltry, Nicole, Niedermeyer, Joachim, Lee, Woon Kyu, Baron, Roland, Rawadi, Georges, Westphal, Heiner, Niehrs, Christof

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells by Jackson, Amanda, Vayssière, Béatrice, Garcia, Teresa, Newell, William, Baron, Roland, Roman-Roman, Sergio, Rawadi, Georges

“…Wnt/β-catenin signaling is involved in a large variety of modeling and remodeling processes including cell polarity, cell differentiation, and cell migration…”
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Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products by Lien, Egil, Sellati, Timothy J., Yoshimura, Atsutoshi, Flo, Trude H., Rawadi, Georges, Finberg, Robert W., Carroll, J. David, Espevik, Terje, Ingalls, Robin R., Radolf, Justin D., Golenbock, Douglas T.

“…Toll-like receptors (TLRs) 2 and 4 are signal transducers for lipopolysaccharide, the major proinflammatory constituent in the outer membrane of Gram-negative…”
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Interaction between LRP5 and Frat1 Mediates the Activation of the Wnt Canonical Pathway by Hay, Eric, Faucheu, Chi, Suc-Royer, Isabelle, Touitou, Robert, Stiot, Veronique, Vayssière, Béatrice, Baron, Roland, Roman-Roman, Sergio, Rawadi, Georges

“…Low density lipoprotein receptor-related protein 5 (LRP5) has been identified as a Wnt co-receptor involved in the activation of the β-catenin signaling…”
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Involvement of Mitogen-Activated Protein Kinase Pathways in Interleukin-8 Production by Human Monocytes and Polymorphonuclear Cells Stimulated with Lipopolysaccharide or Mycoplasma fermentans Membrane Lipoproteins by MARIE, C, ROMAN-ROMAN, S, RAWADI, G

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Expression, purification and characterization of murine Dkk1 protein by Fleury, Damien, Gillard, Corinne, Lebhar, Helène, Vayssière, Béatrice, Touitou, Robert, Rawadi, Georges, Mollat, Patrick

“…Dickkopf-1 (Dkk1) protein is a secreted inhibitor of canonical Wnt signaling and modulates that pathway during embryonic development. It is also implicated in…”
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1-(5-Oxohexyl)-3,7-Dimethylxanthine, a Phosphodiesterase Inhibitor, Activates MAPK Cascades and Promotes Osteoblast Differentiation by a Mechanism Independent of PKA Activation (Pentoxyfilline Promotes Osteoblast Differentiation) by Rawadi, Georges, Ferrer, Caroline, Spinella-Jaegle, Sylviane, Roman-Roman, Sergio, Bouali, Yasmina, Baron, Roland

“…We have investigated the effect of 1-(5-oxohexyl)-3,7-dimethylxanthine or pentoxifylline (PeTx), a nonselective phosphodiesterase inhibitor, on osteoblastic…”
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Safety Evaluation of Christensenella Minuta as a Novel Microbiome-Based Biotherapy to Treat Obesity by Claus, Sandrine, Mazier, Wilfrid, Frederic, Elustondo, Paquet, Jeanne-Celeste, Rinaldi, Laure, Dejean, Guillaume, Rasmussen, Scott, Rawadi, Georges

“…Background: Obesity is associated with a dysbiotic gut microbiome characterized by low microbial diversity and a loss of Christensenella minuta, which are low…”
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Wnt Signaling: A Key Regulator of Bone Mass by Baron, Roland, Rawadi, Georges, Roman‐Roman, Sergio

“…The identification of a link between bone mass in humans and gain‐ [high bone mass (HBM) trait] or loss‐of‐function [osteoporosis pseudoglioma (OPPG) syndrome]…”
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Involvement of Small GTPases in Mycoplasma fermentans Membrane Lipoproteins-mediated Activation of Macrophages by Rawadi, Georges, Zugaza, Jose-Luis, Lemercier, Brigitte, Marvaud, Jean Christophe, Popoff, Michel, Bertoglio, Jacques, Roman-Roman, Sergio

“…Mycoplasma fermentans lipoproteins (LAMPf) are capable of activating macrophages and inducing the secretion of proinflammatory cytokines. We have recently…”
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